Purification and characterization of a thrombin inhibitor from the salivary glands of a malarial vector mosquito, Anopheles stephensi

Biochimica et Biophysica Acta - General Subjects

Volumn 1381, Issue 2, 1998, Pages 227-233

  Waidhet Kouadio, Philomene ^a   Yuda, Masao ^a   Ando, Katsushito ^a   Chinzei, Yasuo ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Anopheles stephensi; Salivary gland; Thrombin inhibitor

Indexed keywords

THROMBIN INHIBITOR;

ANION EXCHANGE CHROMATOGRAPHY; ANOPHELES; ANTICOAGULATION; ARTICLE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG PURIFICATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; SALIVARY GLAND;

ANIMALS; ANOPHELES; ANTICOAGULANTS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; HUMANS; MALARIA; MOLECULAR WEIGHT; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; SALIVARY GLANDS; THROMBIN;

EID: 0031879188     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(98)00026-9     Document Type: Article

References (13)

1. J.M.C. Ribeiro, Role of saliva in blood-feeding by arthropods, Annu. Rev. Entomol. 32 (1987) 463-478.
2. J.M.C. Ribeiro, Blood-feeding arthropods: live syringes or invertebrate pharmacologists?, Infect. Agents Dis. 4 (1995) 143-152.
3. K.R. Stark, A.A. James, Anticoagulant in vector arthropods, Parasitol. Today 12 (1996) 430-437.
4. K.R. Stark, A.A. James, Salivary gland anticoagulants in culicine and anopheline mosquitoes (Diptera: Culicidae), J. Med. Entomol. 33 (1996) 645-650.
5. K.R. Stark, A.A. James, A factor Xa-directed anticoagulant from the salivary glands of the yellow fever mosquito Aedes aegypti, Exp. Parasitol. 81 (1995) 321-331.
6. J.W. Fenton, Thrombin, Ann. New York Acad. Sci. 485 (1986) 5-15.
7. F. Markwardt, Coagulation inhibitor from blood-sucking animals. A new line of developing antithrombotic drugs, Dpt. Parmacol. Toxicol. 49 (1994) 313-316.
8. J.M.C. Ribeiro, P.A. Rossignol, A. Spielman, Salivary gland apyrase determines probing time in Anopheline mosquitoes, J. Insect Physiol. 31 (1985) 689-692.
9. J.W. Fenton, Semin. Thromb. Hemost. 15 (1989) 265-268.
10. C. Noeske-jungblut, B. Haendler, P. Donner, A.A. Triabin, A highly potent exosite inhibitor of thrombin, J. Biol. Chem. 270 (1995) 28629-28634.
11. M. Cappello, P.W. Bergum, G.P. Vlasuk, B.A. Furmidge, D.I. Pritchard, S. Aksoy, Isolation and characterization of the tsetse thrombin inhibitor: a potent antithrombotic peptide from the saliva of Glossina morsitans morsitans, Am. J. Trop. Med. Hyg. 54 (1996) 475-480.
12. M. Abebe, M.S. Cupp, D. Champagne, E.W. Cupp, Simulidin: a black fly (Simulium vittatum) salivary gland protein with anti-thrombin activity, J. Insect Physiol. 41 (1995) 1001-1006.
13. T. Friedrich, B. Kroger, S. Bialojan, H.G. Lemaire, H.W. Hoffken, P. Reushenbach, M. Otte, J. Dodt, A kazal-type inhibitor with thrombin specificity from Rhodnius prolixus, J. Biol. Chem. 268 (1993) 16216-16222.