Zinc as a treatment for age-related macular degeneration

Journal of Trace Elements in Experimental Medicine

Volumn 11, Issue 2-3, 1998, Pages 137-145

  Olson, Randall J ^a,b   DeBry, Peter ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Macular degeneration; Retinal pigment epithelium

Indexed keywords

ANTIOXIDANT; ZINC;

ARTICLE; HUMAN; ORAL DRUG ADMINISTRATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA DEGENERATION;

EID: 0031879048     PISSN: 0896548X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-670X(1998)11:2/3<137::AID-JTRA6>3.0.CO;2-5     Document Type: Article

References (36)

1. National Advisory Eye Council, Report of the Retinal and Choroidal Disease Panel: "Vision Research - A National Plan: 1983-1987." Bethesda, MD: US Dept of Health and Human Services, 1984, National Institutes of Health Publication 83-2471.
2. Klein R, Klein B, Linton KLP: Prevalence of age-related maculopathy: The Beaver Dam Study. Ophthalmology 99:933-943, 1992.
3. The Eye Disease Case-Control Study Group: Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 111:104-109, 1993.
4. The Eye Disease Case-Control Study Group: Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 272:1413-1420, 1994.
5. Galin MA, Nano HD, Hall T: Ocular zinc concentration. Invest Ophthalmol Vis Sci 1:142-147, 1962.
6. Young RW: Pathophysiology of age-related macular degeneration. Surv Ophthalmol 31:291-306, 1987.
7. The Macular Photocoagulation Study Group: Argon laser photocoagulation for senile macular degeneration: Results of a randomized clinical trial. Arch Ophthalmol 100:912-918, 1982.
8. Karcioglu ZA, Sarper MR: "Zinc and Copper in Medicine." Springfield, IL: Charles C. Thomas, 1980.
9. Keilin D, Mann T: Carbonic anhydrase. Nature 144:42, 1939.
10. Kagi JHR, Vallee BL: The role of zinc agents in alcohol dehydrogenase. V. The effects of metal-binding agents on the structure of the yeast alcohol dehydrogenase molecule. J Biol Chem 235:3188-3192, 1960.
11. Carpenter FH, Vahl TM: Leucine aminopeptidase (bovine lens). J Biol Chem 248:294-304, 1973.
12. Prasad AS, Miale A, Jr, Farid Z, et al.: Biochemical studies on dwarfism, hypogonadism, and anemia. Arch Intern Med 111:407-428, 1963.
13. Morrison SA, Russell RM, Carney EA, Oaks EV: Zinc deficiency: A cause of abnormal dark adaptation in cirrhotics. Am J Clin Nutr 31:276-281, 1978.
14. Taylor HR, West S, Munoz B, Rosenthal FS, Bressler SB, Bressler NM: The long-term effects of visible light on the eye. Arch Ophthalmol 110:99-104, 1992.
15. Gottsch JD, Pou S, Bynoe LA, Rosen GM: Hematogenous photosensitization. A mechanism for the development of age-related macular degeneration. Invest Ophthalmol Vis Sci 31:1674-1682, 1990.
16. Young RW: Solar radiation and age-related macular degeneration. Surv Ophthalmol 32:252-269, 1988.
17. Eagle RC, Jr: Mechanisms of maculopathy. Ophthalmology 91:613-625, 1984.
18. Newsome DA, Swartz M, et al: Oral zinc in macular degeneration. Arch Ophthalmol 106:192-198, 1988.
19. Beaumont P: Zinc and macular degeneration (letter). Arch Ophthalmol 111:1023, 1993.
20. Klevay LM: The role of copper, zinc, and other trace metals in ischemia. In Robert OM, Chan WY (eds): "Metabolism of Metals in Man." Boca Raton, FL: CRC Press, 1984, Vol 2: Genetic Implications, pp 129-157.
21. Brown ER, Griest A, Tricot G, Hoffman R: Excessive zinc ingestion: A reversible cause of sideroblastic anemia and bone marrow depression. JAMA 264:1441-1443, 1990.
22. The Age-Related Eye Disease Study: "Manual of Procedures." Bethesda, MD: National Eye Institute, 1991.
23. Olson RJ, Mamalis N, et al: Antioxidants and macular degeneration (letter). J Cataract Refract Surg 17:245-246, 1991.
24. Wyszynski RE, Bruner WE, Cano DB, Morgan KM, Davis CB, Sternberg P: A donor-age-dependent change in the activity of alpha-mannosidase in human cultured RPE cells. Invest Ophthalmol Vis Sci 30:2341-2347, 1989.
25. Hirani S, Winchester BG, Patrick AD: Measurement of the α-mannosidase activities in human plasma by a differential assay. Clin Chim Acta 81:135, 1977.
26. Miceli MV, Newsome DA: Insulin stimulation of retinal outer segment uptake by cultured human retinal pigment epithelial cells determined by a flow cytometric method. Exp Eye Res 59:271-280, 1994.
27. The Eye Disease Case-control Study Group: Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 110:1701-1708, 1992.
28. Silverstone BZ, Landau L, Berson D, Sternbuch J: Zinc and copper metabolism in patients with senile macular degeneration. Ann Ophthalmol 17:419-422, 1985.
29. Silverstone BZ, Seelenfreund MH, Ronen S, Kristol L, Algur N, Berson D: A metabolic analysis of high myopia and senile macular degeneration. Metab Pediatr Syst Ophthalmol 11:122-125, 1988.
30. Silverstone BA, Berson D, Grushka E, Kristol L, Hirsch I, Algur N: Copper and zinc levels after external damage by laser photocoagulation to the retinal pigment epithelium. Preliminary reports. Metab Pediatr Syst Ophthalmol 8:61-68, 1985.
31. Silverstone BZ, Kristol L, Algur N, Berson D, Sternbuch J: Changes in the zinc and copper metabolism after panretinal photocoagulation in the rabbit. Ann Ophthalmol 19:100-103, 1987.
32. Lilees MR, Newsome DA, Oliver PD: Antioxidant enzymes in the aging human retinal pigment epithelium. Arch Ophthalmol 109:1285-1288, 1991.
33. Prashar S, Pandav SS, Gupta A, Nath R: Antioxidant enzymes in RBCs as a biological index of age related macular degeneration. Acta Ophthalmol Copenh 71:214-218, 1993.
34. West S, Vitale S, Hallfrisch J, et al.: Are antioxidants or supplements protective for age-related macular degeneration? Arch Ophthalmol 112:222-227, 1994.
35. Wagner PA: Zinc nutriture in the elderly. Geriatrics 40:111-125, 1985.
36. Solomons NW: On the assessment of zinc and copper nutriture in man. Am J Clin Nutr 32:856-871, 1979.