Aqueous humour concentration and the intraocular pressure-lowering effect of topical betaxolol before cataract surgery

European Journal of Clinical Pharmacology

Volumn 54, Issue 5, 1998, Pages 389-392

  Vainio Jylha E ^a,b   Vuori, M L ^a   Kaila, T ^a   Huupponen, R ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Betaxolol; Intraocular pressure

Indexed keywords

ADRENALIN; BETAXOLOL; BUPIVACAINE; CYCLOPENTOLATE; HYALURONIDASE; LIDOCAINE; METAOKSEDRIN; PHENYLEPHRINE; PLACEBO; SYKLO; UNCLASSIFIED DRUG;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG TISSUE LEVEL; FEMALE; HUMAN; INTRAOCULAR DRUG ADMINISTRATION; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; MALE; PERIBULBAR ANESTHESIA; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC BETA-ANTAGONISTS; AGED; AGED, 80 AND OVER; AQUEOUS HUMOR; BETAXOLOL; CATARACT; CATARACT EXTRACTION; COMBINED MODALITY THERAPY; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTRAOCULAR PRESSURE; MALE; PLACEBOS; PREOPERATIVE CARE;

EID: 0031878001     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050480     Document Type: Article

References (29)

1. Zimmerman TJ, Kaufman HE (1977) Timolol, a β-adrenergic blocking agent for the treatment of glaucoma. Arch Ophthalmol 95: 601-604
2. Berrospi AR, Leibowitz HM (1982) Betaxolol, a new β-adrenergic blocking agent for treatment of glaucoma. Arch Ophthalmol 100: 943-946
3. McMahon CD, Shaffer RN, Hoskins HD, Hetherington J (1979) Adverse effects experienced by patients taking timolol. Am J Ophthalmol 88: 736-738
4. Kaila T, Salminen L, Huupponen R (1985) Systemic absorption of topically applied ocular timolol. J Ocul Pharmacol Ther 1: 79-83
5. Vuori M-L, Ali-Melkkilä T, Kaila T, Iisalo E, Saari KM (1993) Plasma and aqueous humour concentrations and systemic effects of topical betaxolol and timolol in man. Acta Ophthalmol Scand 71: 201-206
6. Allen RC, Hertzmark E, Walker AM, Epstein DL (1986) A double-masked comparison of betaxolol vs timolol in the treatment of open-angle glaucoma. Am J Ophthalmol 101: 535-541
7. Kitazawa Y, Azuma I, Araie M (1989) Clinical evaluation of betaxolol hydrochloride in the treatment of primary open angle glaucoma and ocular hypertension: multicentre double-masked study in comparison with timolol. Rinsho Hyoka 17: 243-274
8. Nordlund JR, Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J (1995) The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine. Arch Ophthalmol 113: 77-83
9. Vuori M-L, Kaila T, Iisalo E, Saari KM (1993) Concentrations and antagonist activity of topically applied betaxolol in aqueous humour. Acta Ophthalmol Scand 71: 677-681
10. Kaila T (1991) A sensitive radioligand binding assay for timolol in plasma. J Pharm Sci 80: 296-299
11. Shell JW (1982) Pharmacokinetics of topically applied ophthalmic drugs. Surv Ophthalmol 26: 207-218
12. Whitson JT, Love R, Brown RH, Lynch MG, Schoenwald RD (1993) The effect of reduced eyedrop size and eyelid closure on the therapeutic index of phenylephrine. Am J Ophthalmol 115: 357-359
13. Lynch MG, Brown RH, Goode SM, Schoenwald RD, Chien D-S (1987) Reduction of phenylephrine drop size in infants achieves equal dilation with decreased systemic absorption. Arch Ophthalmol 105: 1364-1365
14. Alvan G, Calissendorff B, Seideman P, Widmark K, Widmark G (1980) Absorption of ocular timolol. Clin Pharmacokinet 5: 95-100
15. Murray DL, Leopold IH (1985) Alpha-adrenergic receptors in rabbit eyes. J Ocul Pharmacol Ther 1: 3-18
16. Innemee HC, de Jonge A, van Meel JC, Timmermans PB, van Zwielen PA (1981) The effect of selective alpha 1- and alpha 2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit. Naunyn Schmiedeberg's Arch Pharmacol 316: 294-298
17. Van Genderen MM, Van Best JA, Oosterhuis JA (1988) The immediate effect of phenylephrine on aqueous flow in man. Invest Ophthalmol Vis Sci 29: 1469-1473
18. Araie M, Mori M, Oshika T (1992) Effect of topical phenylephrine on the permeability of the blood-aqueous barrier in man. Graefes Arch CTm Exp Ophthalmol 230: 171-174
19. Mapstone R (1981) Pigment release. Br J Ophthalmol 65: 258-263
20. Valle O (1976) The cyclopentolate provocative test in suspected or untreated open-angle glaucoma III. The significance of pigment for the result of the cyclopentolate provocative test in suspected or untreated open-angle glaucoma. Acta Ophthalmol Scand 54: 654-664
21. Edelhauser HF, Hine JE, Pederson H, Van Horn DL, Schultz RO (1979) The effect of phenylephrine on the cornea. Arch Ophthalmol 97: 937-947
22. Staatz WD, Van Horn DL, Edelhauser HF, Schultz RO (1980) Effects of phenylephrine on bovine conical endothelium in culture. Ophthalmic Res 12: 244-251
23. Kyyrönen K, Urtti A (1990) Improved ocular:systemic absorption ratio of timolol by viscous vehicle and phenylephrine. Invest Ophthalmol Vis Sci 31: 1827-1833
24. Podder SK, Moy KC, Lee VH (1992) Improving the safety of topically applied timolol in the pigmented rabbit through manipulation of formulation composition. Exp Eye Res 54: 747-757
25. Lee YH, Lee VH (1993) Formulation influence on ocular and systemic absorption of topically applied atenolol in the pigmented rabbit. J Ocul Pharmacol Ther 9: 47-58
26. De Jong C, Stolwijk T, Kuppens E, De Keizer R, Van Best J (1994) Topical timolol with and without benzalkonium chloride: epithelial permeability and autofluorescence of the cornea in glaucoma. Graefes Arch Clin Exp Ophthalmol 232: 221-224
27. Denis P, Demailly P, Saraux H (1993) Clinical evaluation of betaxolol in ophthalmic suspension with or without preservative agent in patients with glaucoma or ocular hypertension (in French). J Fr Ophtalmol 16: 297-303
28. Lee VHL, Luo AM, Li S, Podder SK, Cluing JS-C, Ohdo S, Grass GM (1991) Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations. Invest Ophthalmol Vis Sci 32: 2948-2957
29. Nathanson JA (1981) Human ciliary process adrenergic receptor: pharmacological characterization. Invest Ophthalmol Vis Sci 21: 798-804