Ursodeoxycholic acid in the treatment of flutamide-induced hepatotoxicity

Nishinihon Journal of Urology

Volumn 60, Issue 7, 1998, Pages 533-535

  Yamamoto, Akihiro ^a   Hashine, Katsuyoshi ^b   Sumiyoshi, Yoshiteru ^b   Akazawa, Seiji ^c   Aki, Masashi ^d   Kuwahara, Morimasa ^d  

^a Kochi Takasu Hospital   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

^c Health Insurance Naruto Hospital   (Japan)

^d Fujisaki Hospital   (Japan)

Author keywords

Drug induced hepatitis; Flutamide; Hepatotoxicity; Ursodeoxycholic acid

Indexed keywords

FLUTAMIDE; URSODEOXYCHOLIC ACID;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER HORMONE THERAPY; CLINICAL ARTICLE; DRUG EFFICACY; DRUG INDUCED DISEASE; HEPATITIS; HUMAN; MALE; PROSTATE CANCER;

EID: 0031877474     PISSN: 00290726     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Wysowski, D. K. et al. : Flutamide hepatotoxicity. J. Urol. 155 : 209-212, 1996.
2. Nakamura, K. et al. : Liver and biliary ; Increase of sulfated ursodeoxycholic acid in the serum and urine of patients with chronic liver disease after ursodeoxycholic acid therapy. J. Gastroen. Hepatol. 11 : 385-390, 1996.
3. Saksena, S. and Tandon, R. K. : Ursodeoxycholic acid in the treatment of liver diseases. Postgrad. Med. J. 73 : 75-80, 1997.
4. Crawford, E. D et al. : A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl. J. Med. 321 : 419-424, 1989.
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6. Cicognani, C. et al. : Flutamide-induced toxic hepatitis: Potential utility of ursodeoxycholic acid administration in toxic hepatitis. Dig. Dis. Sci. 41 : 2219-2221, 1996.
7. Gomez, J. L. et al. : Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients. Am. J. Med. 92 : 465-470, 1992.