메뉴 건너뛰기




Volumn 176, Issue 3, 1998, Pages 525-536

KT5720 and U-98017 inhibit MAPK and alter the cytoskeleton and cell morphology

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; KT 5720; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; STAUROSPORINE; TUBULIN; U 98017; UNCLASSIFIED DRUG;

EID: 0031877380     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199809)176:3<525::AID-JCP9>3.0.CO;2-Q     Document Type: Article
Times cited : (27)

References (41)
  • 1
    • 0028148826 scopus 로고
    • K252a, KT5720, KT5926, and U98017, support paclitaxel (taxol) dependent cells and synergize with paclitaxel
    • Abraham, I., Wolf, C.L., Sampson, K.E., Laborde, A.L., Shelly, J.A., Aristoff, P.A., and Skulnick, H.I. (1994) K252a, KT5720, KT5926, and U98017, support paclitaxel (taxol) dependent cells and synergize with paclitaxel. Cancer Res., 54:5889-5894.
    • (1994) Cancer Res. , vol.54 , pp. 5889-5894
    • Abraham, I.1    Wolf, C.L.2    Sampson, K.E.3    Laborde, A.L.4    Shelly, J.A.5    Aristoff, P.A.6    Skulnick, H.I.7
  • 2
    • 0027757042 scopus 로고
    • Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5
    • Baumann, K., Mandelkow, E.-M., Biernat, J., Piwnica-Worms, H., and Mandelkow, E. (1993) Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett., 336:417-424.
    • (1993) FEBS Lett. , vol.336 , pp. 417-424
    • Baumann, K.1    Mandelkow, E.-M.2    Biernat, J.3    Piwnica-Worms, H.4    Mandelkow, E.5
  • 3
    • 0019171148 scopus 로고
    • Microtubule-associated proteins from cultured HeLa cells: Analysis of molecular properties and effects on microtubule polymerization
    • Bulinski, J.C., and Borisy, G.G. (1980) Microtubule-associated proteins from cultured HeLa cells: Analysis of molecular properties and effects on microtubule polymerization. J. Biol. Chem., 255:11570-11576.
    • (1980) J. Biol. Chem. , vol.255 , pp. 11570-11576
    • Bulinski, J.C.1    Borisy, G.G.2
  • 4
    • 0019827946 scopus 로고
    • Isolation of a taxol-resistant Chinese hamster cell mutant that has an alteration in alpha-tubulin
    • Cabral, F., Abraham, I., and Gottesman, M.M. (1981) Isolation of a taxol-resistant Chinese hamster cell mutant that has an alteration in alpha-tubulin. Proc. Nat. Acad. Sci. USA 78:4388-4391.
    • (1981) Proc. Nat. Acad. Sci. USA , vol.78 , pp. 4388-4391
    • Cabral, F.1    Abraham, I.2    Gottesman, M.M.3
  • 5
    • 0020632261 scopus 로고
    • Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly
    • Cabral, F., Wible, L., Brenner, S., and Brinkley, B.R. (1983) Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly. J. Cell Biol. 97:30-39.
    • (1983) J. Cell Biol. , vol.97 , pp. 30-39
    • Cabral, F.1    Wible, L.2    Brenner, S.3    Brinkley, B.R.4
  • 6
    • 0029863927 scopus 로고    scopus 로고
    • Association of Mitogen activated protein kinases with microtubules in mouse macrophages
    • Ding, A., Chen, B., Fuortes, M., and Blum, E. (1996) Association of Mitogen activated protein kinases with microtubules in mouse macrophages. J. Exp. Med. 183:1899-1904.
    • (1996) J. Exp. Med. , vol.183 , pp. 1899-1904
    • Ding, A.1    Chen, B.2    Fuortes, M.3    Blum, E.4
  • 7
    • 0027184141 scopus 로고
    • p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites
    • Fiore, R.S., Bayer, V.E., Pelech, S.L., Posada, J., Cooper, J.A., and Baraban, J.M. (1993) p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites. Neuroscience, 55:463-472.
    • (1993) Neuroscience , vol.55 , pp. 463-472
    • Fiore, R.S.1    Bayer, V.E.2    Pelech, S.L.3    Posada, J.4    Cooper, J.A.5    Baraban, J.M.6
  • 8
    • 0021774470 scopus 로고
    • Tubulin-colchicine complexes differentially poison opposite microtubule ends
    • Farrell, K.W., and Wilson, L. (1984) Tubulin-colchicine complexes differentially poison opposite microtubule ends. Biochemistry, 23:3741-3748.
    • (1984) Biochemistry , vol.23 , pp. 3741-3748
    • Farrell, K.W.1    Wilson, L.2
  • 10
    • 0029680383 scopus 로고    scopus 로고
    • A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation
    • Hall, L.L., Th'ng, J.P.H., Guo, X.W., Teplitz, R.L., and Bradbury, E.M. (1996) A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. Cancer Res., 56:3551-3559.
    • (1996) Cancer Res. , vol.56 , pp. 3551-3559
    • Hall, L.L.1    Th'ng, J.P.H.2    Guo, X.W.3    Teplitz, R.L.4    Bradbury, E.M.5
  • 11
    • 0026517618 scopus 로고
    • Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-associated protein 4, induces an alteration in their function
    • Hoshi, M., Ohta, K., Gotoh, Y., Mori, A., Murofushi, H., Sakai, H., and Nishida, E. (1992) Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-associated protein 4, induces an alteration in their function. Eur. J. Biochem., 203:43-52.
    • (1992) Eur. J. Biochem. , vol.203 , pp. 43-52
    • Hoshi, M.1    Ohta, K.2    Gotoh, Y.3    Mori, A.4    Murofushi, H.5    Sakai, H.6    Nishida, E.7
  • 12
    • 0002308542 scopus 로고
    • New inhibitors of protein kinases from microbial source
    • Y. Okami, T. Beppu, and H. Ogawara, eds. Japan Scientific Societies Press, Tokyo
    • Kase, H. (1988) New inhibitors of protein kinases from microbial source. In: Biology of Actinomycetes. Y. Okami, T. Beppu, and H. Ogawara, eds. Japan Scientific Societies Press, Tokyo, pp. 159-164.
    • (1988) Biology of Actinomycetes , pp. 159-164
    • Kase, H.1
  • 14
    • 0026029189 scopus 로고
    • Activation of MAP kinase and enhanced phosphorylation of the 350 kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells
    • Kawakami, M., Nishida, E., Tobe, K., Hoshi, M., Kadowaki, T., Kasuga, M., and Sakai, H. (1991) Activation of MAP kinase and enhanced phosphorylation of the 350 kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells. Exp. Cell Res., 193:120-126.
    • (1991) Exp. Cell Res. , vol.193 , pp. 120-126
    • Kawakami, M.1    Nishida, E.2    Tobe, K.3    Hoshi, M.4    Kadowaki, T.5    Kasuga, M.6    Sakai, H.7
  • 16
    • 0025192824 scopus 로고
    • Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts
    • Lamb, N.J., Fernandez, A., Watrin, A., Labbe, J.C., and Cavadore, J.C. (1990) Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell, 60:151-165.
    • (1990) Cell , vol.60 , pp. 151-165
    • Lamb, N.J.1    Fernandez, A.2    Watrin, A.3    Labbe, J.C.4    Cavadore, J.C.5
  • 17
    • 0028223232 scopus 로고
    • Intrinsic microtubule stability in interphase cells
    • Lieuvin, A., Labbe, J.C., Doree, M., and Job, D. (1994) Intrinsic microtubule stability in interphase cells. J. Cell Biol., 124:985-996.
    • (1994) J. Cell Biol. , vol.124 , pp. 985-996
    • Lieuvin, A.1    Labbe, J.C.2    Doree, M.3    Job, D.4
  • 19
    • 0016194956 scopus 로고
    • Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells
    • McBurney, M.W., and Whitmore, G.F. (1974) Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells. Cell 2:173-182.
    • (1974) Cell , vol.2 , pp. 173-182
    • McBurney, M.W.1    Whitmore, G.F.2
  • 20
    • 0029943566 scopus 로고    scopus 로고
    • The pool of MAP kinase associated with microtubules is small but constitutively active
    • Morishima-Kawashima, M., and Kosik, K.S. (1996) The pool of MAP kinase associated with microtubules is small but constitutively active. Mol. Biol. Cell, 7:893-905.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 893-905
    • Morishima-Kawashima, M.1    Kosik, K.S.2
  • 21
    • 0028927505 scopus 로고
    • Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics
    • Ookata, K., Hisanaga, S., Bulinski, J.C., Murofushi, H., Aizawa, H., Itoh, T.J., Hotani, H., Okumura, E., Tachibana, K., and Kishimoto, T. (1995) Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J. Cell Biol., 128:849-862.
    • (1995) J. Cell Biol. , vol.128 , pp. 849-862
    • Ookata, K.1    Hisanaga, S.2    Bulinski, J.C.3    Murofushi, H.4    Aizawa, H.5    Itoh, T.J.6    Hotani, H.7    Okumura, E.8    Tachibana, K.9    Kishimoto, T.10
  • 22
    • 0020332838 scopus 로고
    • Immunofluorescence and immunocytochemical procedures with affinity purified antibodies: Tubulin-containing structures
    • L. Wilson, ed. Academic Press., New York
    • Osborn, M., and Weber, K. (1982) Immunofluorescence and immunocytochemical procedures with affinity purified antibodies: Tubulin-containing structures. In: Methods in Cell Biology. L. Wilson, ed. Academic Press., New York, Vol. 24, pp. 97-131.
    • (1982) Methods in Cell Biology , vol.24 , pp. 97-131
    • Osborn, M.1    Weber, K.2
  • 24
    • 0005261734 scopus 로고
    • Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vivo
    • Ray, L.B., and Sturgill, T.W. (1987) Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vivo. Proc. Natl. Acad. Sci. USA, 84:1502-1506.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1502-1506
    • Ray, L.B.1    Sturgill, T.W.2
  • 25
    • 0029026860 scopus 로고
    • Association of mitogen-activated protein kinase with the microtubule cytoskeleton
    • Reszka, A.A., Seger, R., Diltz, C.D., Krebs, E.G., and Fischer, E.H. (1995) Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc. Natl. Acad. Sci. USA, 92:8881-8885.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8881-8885
    • Reszka, A.A.1    Seger, R.2    Diltz, C.D.3    Krebs, E.G.4    Fischer, E.H.5
  • 26
    • 0030855766 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemtaxis via catalytic and microtubule-specific interactions
    • Reszka, A.A., Bulinski, J.C., Krebs, E.G., and Fischer, E.H. (1997) Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemtaxis via catalytic and microtubule-specific interactions. Mol. Biol. Cell, 8:1219-1232.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1219-1232
    • Reszka, A.A.1    Bulinski, J.C.2    Krebs, E.G.3    Fischer, E.H.4
  • 27
    • 0022552877 scopus 로고
    • Taxol-dependent mutants of Chinese hamster ovary cells with alterations in α- and β-tubulin
    • Schibler, M.J., and Cabral, F. (1986) Taxol-dependent mutants of Chinese hamster ovary cells with alterations in α- and β-tubulin. J. Cell Biol., 102:1522-1531.
    • (1986) J. Cell Biol. , vol.102 , pp. 1522-1531
    • Schibler, M.J.1    Cabral, F.2
  • 28
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff, P.B., and Horwitz, S.B. (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA, 77:1561-1565.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 1561-1565
    • Schiff, P.B.1    Horwitz, S.B.2
  • 29
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff, P.B., Fant, J., and Horwitz, S.B. (1979) Promotion of microtubule assembly in vitro by taxol. Nature (Lond.), 22:665-667.
    • (1979) Nature (Lond.) , vol.22 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 30
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger, R., and Krebs, E.G. (1995) The MAPK signaling cascade. FASEB J., 9:726-735.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 32
    • 0023855504 scopus 로고
    • Rapid phosphorylation of microtubule-associated proteins through distinct mitogenic pathways
    • Shaw, J.P., Chou, I.N., and Anand, B. (1988) Rapid phosphorylation of microtubule-associated proteins through distinct mitogenic pathways. J. Biol. Chem., 263:1459-1466.
    • (1988) J. Biol. Chem. , vol.263 , pp. 1459-1466
    • Shaw, J.P.1    Chou, I.N.2    Anand, B.3
  • 33
    • 0022479478 scopus 로고
    • Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase
    • Sturgill, T.W., and Ray, L.B. (1986) Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase. Bioch. Biophys. Res. Commun., 134:565-571.
    • (1986) Bioch. Biophys. Res. Commun. , vol.134 , pp. 565-571
    • Sturgill, T.W.1    Ray, L.B.2
  • 35
    • 0026250563 scopus 로고
    • Specific association of an M-phase kinase with isolated mitotic spindles and identification of two of its substrates as MAP4 and MAP1B
    • Tombes, R.M., Peloquin, J.G., and Borisy, G.G. (1991) Specific association of an M-phase kinase with isolated mitotic spindles and identification of two of its substrates as MAP4 and MAP1B. Cell Regul., 2:861-874.
    • (1991) Cell Regul. , vol.2 , pp. 861-874
    • Tombes, R.M.1    Peloquin, J.G.2    Borisy, G.G.3
  • 36
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel, S., and Harlow, E. (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science, 262:2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 37
    • 0027258955 scopus 로고
    • MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes
    • Verlhac, M.-H., De Pennart, H., Maro, B., Cobb, M.H., and Clarke, H.J. (1993) MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes. Dev. Biol., 158:330-340.
    • (1993) Dev. Biol. , vol.158 , pp. 330-340
    • Verlhac, M.-H.1    De Pennart, H.2    Maro, B.3    Cobb, M.H.4    Clarke, H.J.5
  • 39
    • 0027073111 scopus 로고
    • Activation of protein serine/ threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: Signal transduction/ transformation-dependent MBP kinases
    • Wang, H.-C.R., and Erikson, R.L. (1992) Activation of protein serine/ threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: Signal transduction/ transformation-dependent MBP kinases. Mol. Biol. Cell, 3:1329-1337.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1329-1337
    • Wang, H.-C.R.1    Erikson, R.L.2
  • 40
    • 0344647981 scopus 로고    scopus 로고
    • A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells
    • Wang, X.M., Zhai, Y., and Ferrell, J.E. (1997) A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells. J. Cell. Biol., 137:433-443.
    • (1997) J. Cell. Biol. , vol.137 , pp. 433-443
    • Wang, X.M.1    Zhai, Y.2    Ferrell, J.E.3
  • 41
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani, M.C., Taylor, H.L., Wall, M.E., Coggon, P., and McPhail, A.T. (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc., 93:2325-2327.
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.