Laxative Poisoning: Toxicological analysis of bisacodyl and its metabolite in urine, serum, and stool

Journal of Analytical Toxicology

Volumn 22, Issue 4, 1998, Pages 274-278

  Kudo, Keiko ^a   Miyazaki, Chiaki ^a   Kadoya, Ryo ^a   Imamura, Tohru ^a   Jitsufuchi, Narumi ^a   Ikeda, Noriaki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BETA GLUCURONIDASE; BISACODYL; DRUG METABOLITE; LAXATIVE; TERT BUTYL METHYL ETHER;

ARTICLE; CASE REPORT; CHILD; CONTROLLED STUDY; DERIVATIZATION; DIARRHEA; DRUG BLOOD LEVEL; DRUG FECES LEVEL; DRUG INTOXICATION; DRUG STRUCTURE; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MASS SPECTROMETRY; METHYLATION; ORAL DRUG ADMINISTRATION; TOXICOLOGY;

EID: 0031877304     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.4.274     Document Type: Article

References (9)

1. J.A. Sugar, M. Belfer, E. Israel, and D. Herzog. A 3-year-old boy's chronic diarrhea and unexplained death. J. Am. Acad. Child Adolesc. Psychiatry 30: 1015-1021 (1991).
2. D.A. Forbes, E.V. O'Loughlin, R.B. Scott, and D.G. Gall. Laxative abuse and secretory diarrhea. Arch. Dis. Child. 60: 58-60 (1985).
3. N.B. Ackerman and C.T. Strobel. Polle syndrome: chronic diarrhea in Munchausen's child. Gastroenterology 81: 1141-1142 (1981).
4. K.D. Fire, C.A. Santa Ana, and J.S. Fordtran. Diagnosis of magnesium-induced diarrhea. New. Engl. J. Med. 324: 1012-1017 (1991).
5. J. Carlson, P. Fernlund, S.-A. Ivarsson, I. Jakobsson, J. Neiderud, K.O. Nilsson, M. Svensson, and U. Swanstein. Munchausen syndrome by proxy: an unexpected cause of severe chronic diarrhoea in a child. Acta Paediatr. 83: 119-121 (1994).
6. R.D. Kacere, S.S. Srivatsa, W.J. Tremaine, L.E. Ebnet, and K.P. Batts. Chronic diarrhea due to surreptitious use of bisacodyl: case reports and methods for detection. Mayo Clin. Proc. 68: 355-357 (1993).
7. L. Loof, P. Hartvig, K. Lanbeck-Vallen, and B. Lindstrom, Quantitation of bisacodyl metabolite in urine for the diagnosis of laxative abuse. Ther. Drug Monit. 2: 345-349 (1980).
8. W. Roth and K. Beschke. Pharmakokinetik und laxierende wirkung von bisacodyl nach gabe verschiedener zubereitungsformen. Arzneim.-Forsch. 38: 570-574 (1988).
9. R.M. Kok and D.B. Faber. Qualitative and quantitative analysis of some synthetic, chemically acting laxatives in urine by gas chromatography-mass spectrometry. J. Chromatogr. 222: 389-398 (1981).