Enhanced endothelium-independent vasodilator response to calcitonin gene-related peptide in hypertensive rats

European Journal of Pharmacology

Volumn 351, Issue 3, 1998, Pages 351-355

  Tomobe, Yoko I ^a   Ishikawa, Tomohisa ^a,b   Goto, Katsutoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

CGRP (calcitonin gene related peptide); Mesenteric artery; Spontaneously hypertensive rat (SHR)

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; CALCITONIN GENE RELATED PEPTIDE; INDOMETACIN; ISOPRENALINE; METHOXAMINE; N(G) NITROARGININE; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; ENDOTHELIUM, VASCULAR; HYPERTENSION; MALE; MESENTERIC ARTERY, SUPERIOR; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASODILATION;

EID: 0031877037     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00379-3     Document Type: Article

References (19)

1. Asano, M., Aoki, K., Matsuda, T., 1982. Reduced beta adrenoceptor interaction of norepinephrine enhances contraction in the femoral artery from spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 223, 207-214.
2. Asano, M., Masuzawa, K., Matsuda, T., Asano, T., 1988. Reduced function of the stimulatory GTP-binding protein in beta adrenoceptor-adenylate cyclase system of femoral arteries isolated from spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 246, 709-718.
3. Bell, D., McDermott, B.J., 1996. Calcitonin gene-related peptide in the cardiovascular system: Characterization of receptor populations and their (patho)physiological significance. Pharmacol. Rev. 48, 253-288.
4. Brain, S.D., Williams, T.J., Tippens, J.R., Morris, H.R., Macintyre, I., 1985. CGRP is a potent vasodilator. Nature 313, 54-56.
5. Cohen, M.L., Berkowitz, B.A., 1976. Decreased vascular relaxation in hypertension. J. Pharmacol. Exp. Ther. 196, 396-406.
6. Dohi, Y., Thiel, M.A., Bühler, F.R., Lüscher, T.F., 1990. Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension. Hypertension 16, 170-179.
7. G-nitro-L-arginine methyl ester. J. Pharmacol. Exp. Ther. 273, 56-63.
8. Fujimori, A., Saito, A., Kimura, S., Watanabe, T., Uchiyama, Y., Kawasaki, H., Goto, K., 1989. Neurogenic vasodilation and release of calcitonin gene-related peptide (CGRP) from perivascular nerves in the rat mesenteric artery. Biochem. Biophys. Res. Commun. 165, 1391-1398.
9. Grace, G.G., Dusting, G.J., Kemp, B.E., Martin, T.J., 1987. Endothelium and the vasodilator action of rat CGRP. Br. J. Pharmacol. 91, 729-733.
10. Gray, D.W., Marshall, I., 1992. Human α-CGRP stimulates adenylate cyclase and guanylate cyclase and relaxes rat thoracic aorta by releasing nitric oxide. Br. J. Pharmacol. 107, 691-696.
11. Hardman, J.G., 1981. Cyclic nucleotides and smooth muscle contraction: some conceptual and experimental considerations. In: Bulbring, A.F., Brading, A.W., Jones, A.W., Tomita, T. (Eds.), Smooth Muscles: An Assessment of Current Knowledge. Arnold, London, pp. 249-262.
12. Kawasaki, H., Takasaki, K., Saito, A., Goto, K., 1988. CGRP is a novel vasodilator neurotransmitter in mesenteric resistance vessels of spontaneously hypertensive rat. Nature 335, 164-167.
13. Kawasaki, H., Saito, A., Takasaki, K., 1990. Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat. Circ. Res. 67, 733-743.
14. Konishi, M., Su, C., 1983. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 5, 881-886.
15. Masuzawa, K., Matsuda, T., Asano, M., 1989. Decreased arterial responsiveness to multiple cyclic AMP-generating receptor agonists in spontaneously hypertensive rats. Br. J. Pharmacol. 96, 227-235.
16. Shirasaki, Y., Kolm, P., Nickols, G.A., Lee, T.J., 1988. Endothelial regulation of cyclic GMP and vascular responses in hypertension. J. Pharmacol. Exp. Ther. 245, 53-58.
17. Shoji, T., Ishihara, H., Ishikawa, T., Saito, A., Goto, K., 1987. Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries. Naunyn-Schmiedeberg's Arch. Pharmacol. 336, 438-444.
18. Tang, J., Xu, D., Yuan, Q.X., Meng, Z.H., Chen, F.R., Chen, M.Z., Liu, G.Z., Liu, L.S., Zhang, Z.K., 1989. Calcitonin gene-related peptide in the pathogenesis and treatment of hypertension. Clin. Med. J. 102, 897-901.
19. Villarreal, D., Freeman, R.H., Verburg, K.M., Brands, M.W., 1988. Effects of CGRP on renal blood flow in the rat. Proc. Soc. Exp. Biol. Med. 188, 316-322.