Targeting of ultrasmall superparamagnetic iron oxide (USPIO) particles to tumor cells in vivo by using transferrin receptor pathways

Magnetic Resonance in Medicine

Volumn 40, Issue 2, 1998, Pages 236-242

  Kresse, Mayk ^a   Wagner, Susanne ^b   Pfefferer, Detlev ^a   Lawaczeck, Rüdiger ^a   Elste, Volker ^a   Semmler, Wolfhard ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Iron oxides; MR imaging; Transferrin; Tumor imaging

Indexed keywords

MAGNETIC RESONANCE IMAGING; MOLECULAR BIOLOGY; RATS; SUPERPARAMAGNETISM; TUMORS;

CONTROL EXPERIMENTS; HUMAN SERUM ALBUMINS; MR IMAGING; PHYSICO-CHEMICAL CHARACTERIZATION; TRANSFERRIN; TRANSFERRIN RECEPTORS; TUMOR IMAGING; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

IRON OXIDES;

DEXTRAN; FERRIC CHLORIDE; FERROUS CHLORIDE; HUMAN SERUM ALBUMIN; IRON OXIDE; TRANSFERRIN; TRANSFERRIN RECEPTOR; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CANCER DIAGNOSIS; CONTROLLED STUDY; COVALENT BOND; DRUG HALF LIFE; DRUG TARGETING; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL CHEMISTRY; RAT; TUMOR CELL;

EID: 0031876774     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910400209     Document Type: Article

References (35)

1. R. Welssledor, A. Bogdanov, M. Papisov, Drug targeting in magnetic resonance imaging. Magn. Reson. Q. 8/1, 55-63 (1992).
2. T. Shibata, R. Weissleder, B. Schaffer, T. Shen, M. Papisov, T. J. Brady, Tissue relaxivities and detectability of monocrystalline iron oxides, in "Proc., SMRM, 11th Annual Meeting, Berlin, 1992," p. 416.
3. L. Josephson. J. Lewis, P. Jacobs, P. F. Hahn, D. D. Stark, The effects of iron oxides on proton relaxivity. Magn. Reson. Imaging 6, 647-653 (1989).
4. R. Weissleder, M. I. Papisov, Pharmaceutical iron oxides for MR imaging. Rev. Magn. Reson. Med. 4, 1-20 (1992).
5. J. T. Ferrucci, D. D. Stark, Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. AJR 155, 943-950 (1990).
6. S. Cerdan, H. R. Lötscher, B. Künnecke, J. Seelig. Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors. Magn. Heson. Med. 12, 151-163 (1989).
7. J. W. M. Bulte, Y. Hoekstra, R. L. Kamman, R. L. Magin, A. G. Webb, R. W. Briggs, K. Gwan Go, C. E. Hulstaert, S. Miltenyi, T. H. The, L. de Leij, Specific MR imaging of human lymphocytes by monoclonal antibody guided dextran-magnetite particles. Magn. Reson. Med. 25, 148-157 (1992).
8. R. Weissleder, A. S. Lee, A. J. Fischman, P. Reimer, T. Shen, R. Wilkinson, R. J. Callahan. T. J. Bracly, Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging. Radiology 181, 245-249 (1991).
9. L. X. Tiefenauer, G. Kühne, R. Y. Andres. Antibody-magnetite nanoparticles: in vitro characterization of a potential tumor-specific contrast agent for magnetic resonance imaging. Bioconjug. Chem. 4, 347-352 (1993).
10. H. Maeda, Y. Matsumura. Tumortropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6, 193-210 (1989).
11. E. Harju, Iron in cancer. A review of the present knowledge, in "Metal Ions in Biology and Medicine" (P. H. Collery, L. A. Poirier, M. Manfait. E. C. Etienne, Eds.), pp. 45-48, John Libbey Eurotext. Paris, 1990.
12. K. C. Gatter, G. Brown. I. S. Trowbridge. R.-E. Woolston, D. Y. Mason, Transferrin receptors in human tissues: their distribution and possible clinical relevance. J. Clin. Pathol. 36, 539-545 (1983).
13. C. R. Hopkins, I. S. Trowbridge, Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 colls, J. Cell Biol, 97, 508-521 (1983).
14. J. H. Brock. Transferrins, in "Metalloproteins, Part 2, Topics in Molecular and Structural Biology" (P. M. Harrison, Ed.). pp. 183-262. Verlag Chemie, Weinheim, 1985.
15. I. S. Trowbridge, R. A. Newman, Monoclonal antibodies to transferrins, in "Receptors and Recognition. Series B, Vol. 17" (M. F. Greaves. Ed.). pp. 235-261, Chapman and Hall, London-New York, 1984.
16. E. Wagner, D. Curiel, M. Cotten, Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis. Adv. Drug Delivery Rev. 14, 113-135 (1994).
17. K. Takahashi, M. Tavassoli, Internalization of iron-transferrin complex by murine L1210 leukemia cells and rat reticulocytes demonstrated by a minibead probe. J. Ultrastruct. Res. 82, 314-321 (1983).
18. M. Vidai, J. Sainte-Marie, J. R, Philippot, A. Bienvenue, The influence of coupling transferrin to liposomes or minibeads on its uptake and fate in leukemic L2C cells. FEBS 216/1, 159-163 (1987).
19. S. H. Hansen, K. Sandvig, B. van Deurs, Internalization efficiency of the transferrin receptor. Exp. Cell Res. 199, 19-28 (1992).
20. L. Josephson, E. V. Groman, E. Menz, J. M. Lewis, H. Bengele, A functionalized superparamagnetic iron oxide colloid as a receptor directed MR contrast agent. Magn. Reson. Imaging 8, 637-646 (1990).
21. B. K. Schaffer, C. Linker, M. Papisov, E. Tsai, N. Nossiff, T. Shibata, A. Bogdanov, T. J. Brady, R. Weissleder, MION-ASF: biokinetics of an MR receptor agent. Magn. Reson. Imaging 11, 411-417 (1993).
22. M. Hasegawa, Y. Ito, H. Yamada, H. Nagae, N. Tozawa, Y. Hino, K. Kito, S. Hokukoku, R. Lawaczeck, W. Ebert, D. Pfefferet, S. Wagner, M. Kresse, Water-soluble carboxypolysaccharide-magnetic iron oxide complex of small particle size. WO 94/03501, (1992).
23. M. Kresse, "Spezifische Kontrastmittel für die Magnetresonanz-Tomographie: Herstellung und Charakterisierung von superparamagnetischen Transferrin-Dextran-und Transferrin-Chondroitin-Magnetiten," Thesis, Fachbereich Pharmazie, Freie Universität Berlin. Berlin, Germany, (1994).
24. A. H. Dutton, K. T. Tokuyasu, S. J. Singer, Iron-dextran antibody conjugates: general method for simultaneous staining of two components in high-resolution immunoelectron microscopy. Proc. Natl. Acad. Sci USA 76/7, 3392-3396 (1979).
25. M. Kresse, D. Pfefferer, K. Thode, R. H. Müller, W. Semmler, Estimation of hydrodynamic sizes of dextran coated iron oxide nanoparticles by size exclusion chromatography (SEC), in "Proc., APGI/APV, 1st World Meeting on Pharmaceutics. Biopharmaceutics, Pharmaceutical Technology, Budapest, 1995," p. 507.
26. U. Kim, Metastatic patterns and properties of tumor cells. Transplant. Proc. 16/2, 373-376 (1984).
27. G. Schuhmann-Giampieri, H. Schmitt-Willich, T. Frenzel, W.-R. Press, J. Weinmann, In vivo and in vitro evaluation of Gd-DTPA-Polylysine as a macromolecular contrast agent for magnetic resonance imaging. Invest. Radiol. 26/11, 969-974 (1991).
28. G. Heinzel, R. Woloszczak, P. Thoman. "TOPFIT 2.0: Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC," Gustav Fischer, Stuttgart-Jena-New York, 1993.
29. S. Wagner, Benign lymph node hyperplasia and lymph node metastases in rabbits. Invest. Radial. 29/3, 364-371 (1994).
30. M. C. Willingham, I. H. Pastan, Receptor-mediated endocytosis: general considerations and morphological approaches, in "Receptor-Mediated Endocytosis, Receptors and Recognition. Series B 15" (P. Cutraceas, T. F. Roth, Eds.], pp. 3-16, Chapman and Hall, London, 1983.
31. W. P. Faulk, B.-L. Hsi, P. J. Stevens, Transferrin and transferrin receptors in carcinoma of the breast. Lancet ii, 390-392 (1980).
32. D. J. A. Crommelin, Colloidal carriers for drug delivery-state of the art: liposomes, in "Proc., Colloidal Drug Carriers-cdc, 1st Expert Meeting, Berlin, Germany, 1995."
33. P. F. Renshaw, C. S. Owen, A. C. McLaughlin, T. G. Frey, J. S. Leigh, Ferromagnetic contrast agents: a new approach. Magn. Reson. Med. 3, 217-225 (1986).
34. H. Busch, H. S. N. Greene, Studies on the metabolism of plasma proteins in tumor-bearing rats. Yale J. Biol. Med. 27, 339-349 (1955).
35. H. Sinn, H. H. Schrenk, E. A. Friedrich, U. Schilling, W. Maier-Borst, Design of compounds having an enhanced tumor uptake, using serum albumin as a carrier. Part I. Nucl. Med. Biol. 17/8, 819-827 (1990).