Can one predict protein stability? An attempt to do so for residue 133 of T4 lysozyme using a combination of free energy derivatives, PROFEC, and free energy perturbation methods

Proteins: Structure, Function and Genetics

Volumn 32, Issue 4, 1998, Pages 438-458

  Wang, Lu ^a   Veenstra, David L ^a   Radmer, Randall J ^a   Kollman, Peter A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Free energy simulation; Mutant T4 lysozyme; Packing interaction; Protein stability; S 2 amino 3 cyclopentylpropanoic acid

Indexed keywords

LYSOZYME; PROPIONIC ACID DERIVATIVE;

ARTICLE; ENERGY; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; STEREOCHEMISTRY; THERMODYNAMICS;

BACTERIOPHAGE T4; COMPUTER SIMULATION; ENZYME STABILITY; MODELS, CHEMICAL; MODELS, MOLECULAR; MURAMIDASE; THERMODYNAMICS;

EID: 0031874460     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980901)32:4<438::AID-PROT4>3.0.CO;2-C     Document Type: Article

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