The ultrastructure of human endometrium is altered by administration of intrauterine levonorgestrel

Human Reproduction

Volumn 13, Issue 2, 1998, Pages 1846-1853

  Pakarinen, P I ^a,d   Lahteenmaki P ^b   Lehtonen, E ^c   Reima, I ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Vaestoliitto   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Contraception; Electron microscopy; Endometrium; Levonorgestrel releasing intrauterine system; Ultrastructure

Indexed keywords

LEVONORGESTREL;

ADULT; ARTICLE; BASEMENT MEMBRANE; CELL JUNCTION; CONTROLLED STUDY; DECIDUALIZATION; ENDOMETRIUM; ENDOMETRIUM BIOPSY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; INTRAUTERINE CONTRACEPTIVE DEVICE; INTRAUTERINE DRUG ADMINISTRATION; MENSTRUAL CYCLE; MICROVILLUS; NORMAL HUMAN; SCANNING ELECTRON MICROSCOPY; STROMA CELL; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

EID: 0031873144     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.7.1846     Document Type: Article

References (31)

1. Andersson, J.K. and Rybo, G. (1990) Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia. Br. J. Obstet. Gynaecol., 97, 690-694.
2. Andersson, K., Mattsson, L.A., Rybo, G. et al. (1992) Intrauterine release of levonorgestrel - a new way of adding progestogen in hormone replacement therapy. Obstet. Gynecol., 79, 963-967.
3. Andersson, K., Odlind, V. and Rybo, G. (1994) Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: a randomized comparative trial. Contraception, 49, 56-72.
4. Bentin-Ley, U., Pedersen, B., Lindenberg, S. et al. (1994) Isolation and culture of human endometrial cells in a three-dimensional culture system. J. Reprod. Fertil., 101, 327-332.
5. Brigstock, D.R. (1991) Growth factors in the uterus: steroidal regulation and biological actions. Clin. Endocrinol. Metab., 5, 791-808.
6. Clyman, M-J. (1963) A new structure observed in the nucleolus of the human endometrial epithelial cell. Am. J. Obstet. Gynecol., 86, 430-432.
7. Dockery, P. and Rogers, A.W. (1989) The effects of steroids on the fine structure of the endometrium. Baillières Clin. Obstet. Gynaecol., 3, 227-248.
8. Dockery, P., Warren, M.A., Li, T.C. et al. (1990) A morphometric study of the human endometrial stroma during the peri-implantation period. Hum. Reprod., 5, 112-116.
9. Dockery, P., Ismail, R.M.J., Li, T.C. et al. (1997) The effect of a single dose of mifepristone (RU486) on the fine structure of the human endometrium during the early luteal phase. Hum. Reprod., 12, 1778-1784.
10. Ermini, M., Carpino, F., Petrozza, V. et al (1989) Distribution and effect on the endometrium of progesterone released from a progestasert device. Hum. Reprod., 4, 221-228.
11. Ferenczy, A. (1993) Ultrastructure of the normal menstrual cycle: a review. Microsc. Res. Tech., 25, 91-105.
12. Giudice, L.C. (1994) Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil. Steril., 61, 1-17.
13. Hadisaputra, W., Affandi, B., Witjaksano, J. et al. (1996) Endometrial biopsy collection from women receiving Norplant. Hum. Reprod., 11 (Suppl. 2), 31-34.
14. Hagenfeldt, K., Landgren, B.M., Edström, K. et al. (1977) Biochemical and morphological changes in the human endometrium induced by the Progestasert device. Contraception, 16, 183-197.
15. Hickey, M., Fraser, I., Dwarte, D. et al. (1996) Endometrial vasculature in Norplant users: preliminary results from a hysteroscopic study. Hum. Reprod., 11 (Suppl. 2), 35-44.
16. Horbelt, D.V., Parmley, T.H., Roberts, D.K. et al. (1994) Stromal-epithelial communications in hyperplastic human endometrium. Am. J. Obstet. Gynecol., 170, 1061-1070.
17. Kohorn, E.I., Rice, S.I., Hemperly, S. et al. (1972) The relation of the structure of progestational steroids to nuclear differentiation in human endometrium. J. Clin. Endocrinol., 34, 257-264.
18. Luukkainen, T., Allonen, H., Haukkamaa, M. et al. (1986) Five years' experience with levonorgestrel-releasing IUDs. Contraception, 33, 139-148.
19. Mandelin, E., Koistinen, H., Koistinen, R. et al. (1997) Levonorgestrel-releasing intrauterine device-wearing women express contraceptive glycodelin A in endometrium during midcycle: another contraceptive mechanism? Hum. Reprod., 12, 2671-2775.
20. Martel, D., Frydman, R., Glissant, M. et al. (1987) Scanning electron microscopy of postovulatory human endometrium in spontaneous cycles and cycles stimulated by hormone treatment. J. Endocrinol., 114, 319-324.
21. Murphy, C.R., Rogers, P.A., Hosie, M.J. et al. (1992) Tight junctions of human uterine epithelial cells change during the menstrual cycle: a morphometric study. Acta Anat. Basel., 144, 36-38.
22. Nikas, G., Drakakis, P., Loutradis, D. et al. (1995) Uterine pinopodes as markers of the 'nidation window' in cycling women receiving exogenous oestradiol and progesterone. Hum. Reprod., 10, 1208-1213.
23. Parmley, T.H., Roberts, D.K., Emsa, N.J. et al. (1990) Intercellular contacts between stromal cells in the normal human endometrium throughout the menstrual cycle. Hum. Paihol., 21, 1063-1136.
24. Perino, A., Quartararo, P., Catinella, E. et al. (1987) Treatment of endometrial hyperplasia with levonorgestrel releasing intrauterine devices. Acta Eur. Fertil., 18, 137-140.
25. Pharriss, B.B., Erickson, R., Bashaw, J. et al. (1974) Progestasert. A uterine therapeutic system for long-term contraception: I. Philosophy and clinical efficacy. Fertil. Steril., 25, 915-921.
26. Roberts, D.K., Walker, N.J. and Lavia, L.A. (1988) Ultrastructural evidence of stromal/epithelial interactions in the human endometrial cycle. Am. J. Obstet. Gynecol., 158, 854-861.
27. Rogers, P.A.W. (1996) Endometrial vasculature in Norplant users. Hum. Reprod., 11 (Suppl. 2), 45-50.
28. Sheppard, B.L. (1987) Endometrial morphological changes in IUD users: a review. Contraception, 36, 1-10.
29. Silverberg, S.G., Haukkamaa, M., Arko, H. et al. (1986) Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Pathol., 5, 235-241.
30. Sivin, I., Alvarez, F., Diaz, J. et al. (1984) Intrauterine contraception with c.opper and with levonorgestrel: a randomized study of the TCu 380Ag and levonorgestrel 20 meg/day devices. Contraception, 30, 443-456.
31. Toivonen, J., Luukkainen, T. and Allonen, H. (1991) Protective effect of intrauterine release of. levonorgestrel on pelvic infection: three years' comparative experience of levonorgestrel- and copper-releasing intrauterine devices. Obstet. Gynecol., 77, 261-264.