Serum total sialic acid, a reputed cardiovascular risk factor, and its relationship to lipids, plasma fasting insulin, blood pressure and body mass index in normal individuals

Clinical Science

Volumn 95, Issue 1, 1998, Pages 53-57

  Crook, M ^a   Lumb, P ^a   Andrews, V ^a   Swaminathan, R ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Blood pressure; Cardiovascular risk factor; Hyperinsulinaemia; Insulin resistance; Lipids; Serum sialic acid

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; LIPID; SIALIC ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HIP; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NORMAL HUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; BODY CONSTITUTION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL; FEMALE; HUMANS; INSULIN; LIPIDS; MALE; N-ACETYLNEURAMINIC ACID; REGRESSION ANALYSIS; RISK FACTORS; SEX FACTORS; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES;

EID: 0031872684     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19970239     Document Type: Article

References (32)

1. Lindberg, G., Eklund, G., Gullberg, B. and Rastam, L. (1991) Serum sialic acid concentration and cardiovascular mortality. Br. Med. J. 302, 143-146
2. Lindberg, G., Rastam, L., Gullberg, B. and Eklund, G. A. (1992) Serum sialic acid concentration predicts both coronary heart disease and stroke mortality: multivariate analysis including 54 385 men and women during 20.5 years follow up. Int. J. Epidemiol. 21, 253-257
3. Haq, M., Haq, S., Tutt, P. and Crook, M. (1993) Serum total sialic acid and lipid associated sialic acid in normal subjects and those having a myocardial infarction and their relation to acute phase proteins. Ann. Clin. Biochem. 30, 383-386
4. Crook, M., Haq, M., Haq, S. and Tutt, P. (1994) Serum sialic acid and acute phase proteins in patients with myocardial infarction. Angiology 45, 709-715
5. Crook, M. and Tutt, P. (1992) Serum sialic acid concentration in patients with hypertriglyceridaemia showing the Frederickson's IIB phenotype. Clin. Sci. 83, 593-595
6. Haq, S., Haq, M., Tutt, P. and Crook, M. (1993) Serum sialic acid and acute phase proteins in hypertriglyceridaemic patients showing the Frederickson's type IIB phenotype. Clin. Sci. 85, 219-222
7. Crook, M., Tutt, P. and Pickup, J. C. (1993) Serum sialic acid in non-insulin-dependent diabetes mellitus and its relationship to blood pressure and retinopathy. Diabetes Care 16, 57-60
8. Crook, M., Simpson, H., Tutt, P. and Pickup, J. (1993) Serum total sialic acid and acute phase proteins in type 1 diabetes mellitus. Clin. Chim. Acta 219, 131-138
9. Crook, M., Earle, K., Morocutti, A., Yip, J., Viberti, G. and Pickup, J. C. (1994) Serum sialic acid, a risk factor for cardiovascular disease is increased in insulin-dependent diabetic patients with microalbuminuria and clinical proteinuria. Diabetes Care 17, 305-310
10. Pickup, J. C., Mattock, M. B., Crook, M. A., Chusnay, G. D., Burt, D. and Fitzgerald, A. P. (1995) Serum sialic acid concentration and coronary heart disease in NIDDM. Diabetes Care 18, 1100-1103
11. Flynn, M. D., Corrall, R. J., Waters, P. J. and Pennock, C. A. (1991) Sialic acid and cardiovascular mortality. Br. Med. J. 302, 533-534
12. Mathews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F. and Turner, R. C. (1985) Homeostasis model assessment: insulin resistance and four cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419
13. Welborn, T. A. and Wearne, K. (1979) Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 2, 154-160
14. Ducimetiere, P., Eschwege, E., Papoz, L., Richard, J. L., Claude, J. R. and Rosselin, G. (1980) Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia 19, 205-210
15. Wakabayashi, I., Sakamoto, K., Yoshimoto, S. and Masiu, H. (1992) Relation of serum sialic acid to lipid concentrations. Br. Med. J. 305, 562-563
16. Mathews, K. A., Meilahn, E., Kuller, L. H., Kelsy, S. F., Coggiulu, A. W. and Wing, R. R. (1989) Menopause and risk factors for coronary heart disease. N. Engl. J. Med. 321, 641-646
17. Davis, C. E., Pajak, A., Rywick, S. et al. (1994) Natural menopause and cardiovascular disease risk factors. Ann. Epidemiol. 4, 445-448
18. Stout, R. W. (1987) Insulin and atheroma - an update. Lancet 1, 1077-1079
19. Pyorala, K. (1979) Relationship of glucose intolerance and plasma insulin to the incidence of coronary heart disease. Diabetes Care 2, 131-141
20. Taniuchi, K., Chifu, K. and Hayashi, N. (1981) A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants. Kobe J. Med. Sci. 27, 91-102
21. Crook, M., Treloar, A., Haq, M. and Tutt, P. (1994) Serum total sialic acid and acute phase proteins in elderly subjects. Eur. J. Clin. Chem. Clin. Biochem. 32, 745-747
22. Stuart, J., George, A. J., Davies, A. J., Aukland, A. and Hurlow, R. A. (1981) Haematological stress syndrome in atherosclerosis. J. Clin. Pathol. 34, 464-467
23. Stuart, J. (1984) The acute phase reaction and haematological stress syndrome in vascular disease. Int. J. Microcirc. 3, 115-129
24. De Fronzo, R. A. (1981) The effect of insulin on renal sodium metabolism. Diabetologia 21, 165-171
25. Modan, M., Halkin, H. and Almog, S. (1985) A link between hypertension, obesity and glucose intolerance. J. Clin. Invest. 75, 809-817
26. Reaven, G. M. (1988) Role of insulin resistance in human disease. Diabetes 37, 1595-1607
27. Ferrannini, E., Buzzigoli, G. and Bonadonna, R. (1987) Insulin resistance in essential hypertension. N. Engl. J. Med. 317, 350-357
28. McMillan, D. E. (1989) Increased levels of acute phase serum proteins in diabetes. Metabolism 38, 1042-1046
29. Johnsson, A. and Wales, J. K. (1976) Blood glycoprotein levels in diabetes mellitus. Diabetologia 12, 245-250
30. Pickup, J. C., Mattock, M. B., Chusney, G. D. and Burt, D. (1997) NIDDM as a disease of the innate immune system: association of acute phase reactants and interleukin 6 with metabolic syndrome X. Diabetologia 40, 1286-1292
31. Campos, S. P. and Baumann, H. (1992) Insulin is a prominent modulator of the cytokine stimulated expression of acute phase plasma protein genes. Mol. Cell. Biol. 12, 1780-1797
32. Thompson, D., Harrison, S. P., Evans, S. W. and Whicher, J. T. (1991) Insulin modulation of acute-phase protein production in a human hepatoma-line. Cytokine 3, 619-626