Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH- and urea-induced denaturation

Proteins: Structure, Function and Genetics

Volumn 32, Issue 4, 1998, Pages 495-503

  Hamburger, James B ^a   Chen, Eileen ^a   Narhi, Linda O ^a   Wu, Gay May ^a   Brems, David N ^a  

^a AMGEN INC   (United States)

Author keywords

Conformation; Cytokine; Equilibrium denaturation; Megakaryocyte growth and development factor; Protein folding; Thrombopoietin

Indexed keywords

CYTOKINE; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; THROMBOPOIETIN; UREA;

ARTICLE; CELL GROWTH; CIRCULAR DICHROISM; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HEMATOPOIETIC STEM CELL; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING;

CIRCULAR DICHROISM; CYTOKINES; HUMANS; HYDROGEN-ION CONCENTRATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; THROMBOPOIETIN; ULTRAVIOLET RAYS; UREA;

ESCHERICHIA COLI;

EID: 0031872540     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980901)32:4<495::AID-PROT7>3.0.CO;2-F     Document Type: Article

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