Developmental expression of NMDA receptor subunits and the emergence of glutamate neurotoxicity in primary cultures of murine cerebral cortical neurons

Cellular and Molecular Life Sciences

Volumn 54, Issue 7, 1998, Pages 721-725

  Mizuta, I ^a,d   Katayama, M ^a,c   Watanabe, M ^b   Mishina, M ^c   Ishii, K ^a  

^a KYOTO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Cerebral cortical neuron; Developmental expression; Glutamate neurotoxicity; NMDA receptor subunit; Primary culture

Indexed keywords

GLUTAMIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; IMMUNOBLOTTING; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR DENSITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTAMIC ACID; MICE; MICE, INBRED STRAINS; POLYMERASE CHAIN REACTION; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SIGNAL TRANSDUCTION;

ANIMALIA; EUKARYOTA; MURINAE;

EID: 0031872481     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050199     Document Type: Article

References (34)

1. McDonald J. W. and Johnston M. V. (1990) Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res. Brain Res. Rev. 15: 41-70
2. Monaghan D. T., Bridges R. J. and Cotman C. W. (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29: 365-402
3. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603
4. Collingridge G. L. and Lester R. A. J. (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 41: 143-210
5. Honore T. (1989) Excitatory amino acid receptor subtypes and specific antagonists. Med. Res. Rev. 9: 1-23
6. Choi D. W., Koh J. Y. and Peters S. (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8: 185-196
7. Olney J. W. (1990) Excitotoxic amino acids and neuropsychiatric disorders. Annu. Rev. Pharmacol. Toxicol. 30: 47-71
8. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17: 31-108
9. Seeburg P. H. (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16: 359-365
10. Mishina M., Mori H., Araki K., Kushiya E., Meguro H., Kutsuwada T. et al. (1993) Molecular and functional diversity of the NMDA receptor channel. Ann. NY Acad. Sci. 707: 136-152
11. Nakanishi S. and Masu M. (1994) Molecular diversity and functions of glutamate receptors. Annu. Rev. Biophys. Biomol. Struct. 23: 319-348
12. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M. et al. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268: 2836-2843
13. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K. et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358: 36-41
14. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H. et al. (1992) Heteromeric NMDA receptors: molecular and functional distribution of subtypes. Science 256: 1217-1221
15. Meguro H., Mori H., Araki K., Kushiya E., Kutsuwada T., Yamazaki M. et al. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357: 70-74
16. +-induced depolarization and NMDA treatment. Neuron 12: 87-95
17. Didier M., Xu M., Berman S. A., Saido T. C. and Bursztajn S. (1997) Involvement of three glutamate receptor ε subunits in the formation of N-methyl-D-aspartate receptors mediating excitotoxicity in primary cultures of mouse cerebellar granule cells. Neuroscience 78: 1129-1146
18. Wenzel A., Fritschy J. M., Mohler H. and Benke D. (1997) NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B and NR2C subunit proteins. J. Neurochem. 68: 469-478
19. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N. and Nakanishi S. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354: 31-37
20. Monyer H., Burnashev N., Laurie D. J., Sackmann B. and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540
21. Watanabe M., Inoue Y., Sakimura K. and Mishina M. (1992) Developmental changes in distribution of NMDA-receptor channel subunit mRNAs. Neuroreport 3: 1138-1140
22. Choi D. W., Maulucci-Gedde M. and Kriegstein A. R. (1987) Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7: 357-368
23. Zhong J., Russel S. L., Pritchett D. B., Molinoff P. B. and Williams K. (1994) Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45: 846-853
24. Vallano M. L., Lambolez B., Audinat E. and Rossier J. (1996) Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells. J. Neurosci. 16: 631-639
25. Katayama M. and Ishii K. (1994) 2-Mercaptoethanol-independent survival of fetal mouse brain neurons cultured in a medium of human serum. Brain Res. 656: 409-412
26. Savio T. and Levi G. (1993) Neurotoxicity of HIV coat protein gp120, NMDA receptors and protein kinase C: a study with rat cerebellar granule cell cultures. J. Neurosci. Res. 34: 265-272
27. Katayama M., Mizuta I., Sakoyama Y., Kohyama-Koganeya A., Akagawa K., Uyemura K. et al. (1997) Differential expression of neuroD in primary cultures of cerebral cortical neurons. Exp. Cell Res. 236: 412-417
28. Watanabe M., Fukaya M., Sakimura K., Manabe T., Mishina M. and Inoue Y. (1998) Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre-recipient layer) of the mouse hippocampal CA3 subfield. Eur. J. Neurosci. 10: 478-487
29. Gallo V., Kingsbury A., Balázs R. and Jorgensen O. S. (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7: 2203-2213
30. Balázs R., Jorgensen O. S. and Hack N. (1988) N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience 27: 437-451
31. Wahlestedt C., Golanov E., Yamamoto S., Yee F., Ericson H., Yoo H. et al. (1993) Antisense oligonucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 363: 260-263
32. Tokita Y., Bessho Y., Masu M., Nakamura K., Nakao K., Katsuki M. et al. (1996) Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells. Eur. J. Neurosci. 8: 69-78
33. Sucher N. J., Brose N., Deitcher D. L., Awobuluyi M., Gasic G. P., Bading H. et al. (1993) Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J. Biol. Chem. 268: 22299-22304
34. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci. 13: 1993-2000