Induction of metallothionein isoforms in rat hepatoma cells by various anticancer drugs

Journal of Biochemistry

Volumn 124, Issue 1, 1998, Pages 65-71

  Miyazaki, Hiroaki ^a   Naitoh, Yuji ^a   Nakahashi, Yoshitsugu ^a   Yanagitani, Shingo ^a   Kuno, Kenji ^a   Ueno, Yohji ^a   Okajima, Ai ^a   Inoue, Kyoichi ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Anticancer drug; Drug resistance; Metallothionein; Metallothionein isoform; Rat hepatoma cell

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; DOXORUBICIN; EPIRUBICIN; ISOPROTEIN; MESSENGER RNA; METALLOTHIONEIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; HEPATOMA CELL; IMMUNOFLUORESCENCE; NONHUMAN; PROTEIN INDUCTION; RAT;

ANIMALIA;

EID: 0031871392     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022098     Document Type: Article

References (37)

1. Kägi, J.H.R., Vašák, M., Lerch, K., Gilg, D.E.O., Hunziker, P., Bernhard, W.R., and Good, M. (1984) Structure of mammalian metallothionein. Environ. Health Perspect. 54, 93-103
2. Kägi, J.H.R. and Nordberg, M. (1979) Metallothionein, Proceedings of the First International Meeting on Metallothionein and Other Low Molecular Weight Metal-Binding Proteins, pp. 41-116, Birkhauser Verlag, Boston
3. Kägi, J.H.R. and Schaffer, A. (1988) Biochemistry of metallothionein. Biochemistry 27, 8509-8515
4. Karin, M. and Richards, R.I. (1984) The human metallothionein gene family: structure and expression. Environ. Health Perspect. 54, 111-115
5. Searle, P.F., Davison, B.L., Stuart, G.W., Wilkie, T.M., Norstedt., G., and Palmiter, R.D. (1984) Regulation, linkage and sequence of mouse metallothionein I and II genes. Mol. Cell. Biol. 4, 1221-1230
6. Andersen, R.D., Birren, B.W., Ganz, T., Piletz, J.E., and Herschman, H.R. (1983) Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. DNA 2, 15-22
7. Hamer, D.H. (1986) Metallothionein. Anna. Rev. Biochem. 55, 913-951
8. Andrews, G.K. (1990) Regulation of metallothionein gene expression. Prog. Food Nutr. Sci. 14, 193-258
9. Beach, L.R. and Palmiter, R.D. (1981) Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc. Natl. Acad. Sci. USA 78, 2110-2114
10. Thornalley, P.J. and Vašák, M. (1985) Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta 827, 36-44
11. Shiraishi, N., Hayashi, H., Hiraki, Y., Aono, K., Itano, Y., Kosaka, F., Noji, S., and Taniguchi, S. (1989) Elevation in metallothionein messenger RNA in rat tissues after exposure to X-irradiation. Toxicol. Appl. Pharmacol. 98, 501-506
12. Kelley, S.L., Basu, A., Teicher, B.A., Hacker, M.P., Hamer, D.H., and Lazo, J.S. (1988) Overexpression of metallothionein confers resistance to anticancer drugs. Science 241, 1813-1815
13. Endresen, L., Bakka, A., and Rugstad, H.E. (1983) Increased resistance to chlorambucil in cultured cells with a high concentration of cytoplasmic metallothionein. Cancer Res. 43, 2918-2926
14. Kotsonis, F.K. and Klaassen, C.D. (1979) Increase in hepatic metallothionein in rats treated with alkylating agents. Toxicol. Appl. Pharmacol. 51, 19-27
15. Bakka, A., Endresen, L., Johnsen, A.B.S., Edminson, P.D., and Rugstad, H.E. (1981) Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein. Toxicol. Appl. Pharmacol. 61, 215-226
16. Webber, M.M., Rehman, S.M.M., and James, G.T. (1988) Metallothionein induction and deinduction in human prostatic carcinoma cells: relationship with resistance and sensitivity to adriamycin. Cancer Res. 48, 4503-4508
17. Basu, A. and Lazo, J.S. (1990) A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs. Toxicol. Lett. 50, 123-135
18. Naganuma, A., Satoh, M., and Imura, N. (1987) Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum (II) by induction of metallothionein synthesis without compromising its antitumor activity in mice. Cancer Res. 47, 983-987
19. Calabresi, P. and Schein, P.S. (1993) Medical Oncology: Basic Principles and Clinical Management of Cancer, Mcgraw-Hill, New York
20. Germann, U.A. (1996) P-Glycoprotein - A mediator of multidrug resistance in tumor cells. Eur. J. Cancer 32A, 927-944
21. Southern, E.M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503-517
22. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, pp. 6.3-6.15, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
23. Furukawa, T., Uchiumi, T., Tokunaga, R., and Taketani, S. (1992) Ribosomal protein P2, a novel iron-binding protein. Arch. Biochem. Biophys. 298, 182-186
24. Nakahashi, Y., Taketani, S., Okuda, M., Inoue, K., and Tokunaga, R. (1990) Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase. Biochem. Biophys. Res. Commum. 173, 748-755
25. Taketani, S., Nakahashi, Y., Osumi, T., and Tokunaga, R. (1990) Molecular cloning, sequencing, and expression of mouse ferrochelatase. J. Biol. Chem. 265, 19377-19380
26. Cucco, C. and Calabretta, B. (1996) In vitro and in vivo reversal of multidrug resistance in a human leukemia-resistant cell line by mdr1 antisense oligonucleotides. Cancer Res. 56, 4332-4337
27. 3H]thymidine incorporation assay. J. Immunol. Methods 170, 211-224
28. Douglas-Jones, A.G., Thomas, N.D., Elmes, M.E., and Jasani, B. (1992) Immunocytochemically detectable metallothionein in granulation tissue surrounding mucosal ulceration. Histochem. J. 24, 40-50
29. Giloh, H. and Sedat, J.W. (1982) Fluorescence microscopy: Reduced photobleaching of rhodamine and fluorescein protein conjugates by n-propyl gallate. Science 217, 1252-1255
30. Tung, P.S. and Fritz, I.B. (1994) Role of laminin in the morphogenetic cascade during coculture of Sertoli cells with peritubular cells. J. Cell. Phys. 161, 77-88
31. Sadhu, C. and Gedamu, L. (1988) Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G and MT II-A genes in the hepatoblastoma cell line (HepG2). J. Biol. Chem. 263, 2679-2684
32. Kobayashi, S. and Sayato-Suzuki, J. (1988) Isolation of mouse metallothioneins. A comparison of isometallothioneins in growing cells and post-mitotic cells. Biol. J. 251, 649-655
33. Andrews, G.K. and Adamson, E.D. (1987) Butyrate selectivity activates the metallothionein gene in teratocarcinoma cells and induces hypersensitivity to metal induction. Nucleic Acids Res. 15, 5461-5475
34. Durnam, D.M. and Palmiter, R.D. (1981) Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. Biol. Chem. 256, 5712-5716
35. Kondo, Y., Woo, E.S., Michalska, A.E., Andy Choo, K.H., and Lazo, J.S. (1995) Metallothionein null cells have increased sensitivity to anticancer drugs. Cancer Res. 55, 2021-2023
36. Evans, M.K., Chin, K., Gottesman, M.M., and Bohr, V.A. (1996) Gene-specific DNA repair and steady state transcription of the MDR1 gene in human tumor cell lines. Oncogene 12, 651-658
37. Bahnson, R.R., Becich, M., Ernstoff, M.S., Sandlow, J., Cohen, M.B., and Williams, R.D. (1994) Absence of immunohistochemical metallothionein staining in bladder tumor specimens predicts response to neoadjuvant cisplatin, methotrexate and vinblastine chemotherapy. J. Urol. 152, 2272-2275