Vascular endothelial growth factor in normal human salivary glands and saliva: A possible role in the maintenance of mucosal homeostasis

Laboratory Investigation

Volumn 78, Issue 7, 1998, Pages 869-875

  Taichman, Norton S ^a   Cruchley, Alan T ^d   Fletcher, Laura M ^a   Hagi Pavli, Eleni P ^d   Paleolog, Ewa M ^b   Abrams, William R ^a   Booth, Veronica ^c   Edwards, Rhodri M ^d   Malamud, Daniel ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d Department of Pathology ^*

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; CYTOKINE; MESSENGER RNA; VASCULOTROPIN;

ACINAR CELL; ADULT; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HEALING; HOMEOSTASIS; HUMAN; HUMAN TISSUE; MALE; MOUTH MUCOSA; NORMAL HUMAN; PAROTID GLAND; PRIORITY JOURNAL; SALIVA LEVEL; SALIVARY GLAND; SALIVARY GLAND DUCT; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND;

ADULT; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HOMEOSTASIS; HUMANS; LYMPHOKINES; MALE; MIDDLE AGED; MOUTH MUCOSA; PAROTID GLAND; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALIVA; SALIVARY GLANDS; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031871391     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Berse B, Brown LF, Van De Water L, Dvorak HF, and Senger DR (1992). Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 3:211-220.
2. Bodner L (1991). Effect of parotid, submandibular and sublingual saliva on wound healing in rats. Comp Biochem Physiol 100:887-890.
3. 2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 138:213-221.
4. Brown LF, Yeo K-T, Berse B, Yeo T-K, Senger DR, Dvorak HF, and Van De Water I (1992). Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176:1375-1379.
5. Brown KJ, Maynes SF, Bezoz A, Maguire DJ, Ford MD, and Parish CR (1996). A novel in vitro assay for human angiogenesis. Lab Invest 75:539-555.
6. Brown LF, Claffey DK, Nagy JA, Feng D, Dvorak AM, and Dvorak HF (1997). Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine. EXS 79:233-269.
7. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Ran YC, Olander JV, Connolly DT, and Stern D (1990). Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 172:1535-1545.
8. Connolly DT, Heuvelman D, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber R, and Feder J (1989). Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470-1478.
9. Detmar M, Yeo K-T, Nagy JA, Van De Water L, Brown LF, Berse B, Elicker BM, Ledbetter S, and Dvorak HF (1995). Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol 105:44-50.
10. de Vries C, Escobedo JA, Ueno H, Houck KA, Ferrara N (1992). The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991.
11. Dvorak HF, Brown LF, Detmar M, and Dvorak AM (1995). Vascular permeability factor/vascular endothelial growth factor, microvascular permeability and angiogenesis. Am J Pathol 146:1029-1039.
12. Edgar WM and O'Mullan DM, editors (1996). Saliva and oral health. 2nd ed. London: British Dental Association.
13. Favard C, Moukadiri H, Dorey C, Praloran V, and Poulet J (1991). Purification and biological properties of vasculotropin, a new angiogenic cytokine. Biol Cell 73:1-6.
14. Ferrara N (1995). The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 36:127-137.
15. Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, and Werner S (1995). Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 270:12607-12613.
16. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, and Leung DW (1991). The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5:1806-1814.
17. Houck KA, Leung DW, Rowland AM, Winer J, and Ferrara N (1992). Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267:26031-26037.
18. Hsu J, Romani F, and Tan YS (1996). Expression of vascular endothelial growth factor by the human oral keratinocytes (abstract). J Dent Res 75(Special issue):150.
19. Laemmli UK (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-689.
20. Magi M, Inagaki H, Kojima K, Minami M, and Harada M (1995). Transforming growth factor -α in human submandibular gland and saliva. J Immunoassay 16:379-394.
21. Mandel ID (1987). The functions of saliva. J Dent Res 66(Special issue):623-627.
22. Martinez A, Miller MJ, Quinn K, Unswoth EJ, Ebina M, and Cuttitta F (1995). Non-radioactive localization of nucleic acids by direct in situ PCR and in situ RT-PCR in paraffin-embedded sections. J Histochem Cytochem 43:739-747.
23. Navazesh M (1993). Methods for collecting saliva. In: Malamud D and Tabak L, editors. Saliva as a diagnostic fluid. Ann NY Acad Sci 694:72-77.
24. Niall M, Ryan GB, and O'Brien BM (1982). The effect of epidermal growth factor on wound healing in mice. J Surg Res 33:164-169.
25. Noguchi S, Ohba Y, and Oka T (1991). Effect of salivary epidermal growth factor on wound healing of tongue in mice. Am J Phys 260:E620-E625.
26. Park JE, Keller GA, and Ferrara N (1993). The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of the extracellular matrix-bound VEGF. Mol Biol cell 4:1317-1326.
27. Pepper MS, Ferrara N, Orci L, and Montesano R (1991). Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181:902-906.
28. Quinn T, Peters KG, de Vries C, Ferrara N, and Williams LT (1993). Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90:7533-7537.
29. Rooman I, Schuit F, and Bouwens L (1997). Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium. Lab Invest 76:225-232.
30. 3 integrin, osteopontin and thrombin. Am J Pathol 149:293-305.
31. Skinner KA and Tepperman BL (1981). Influence of desalivation on acid secretory output and gastric mucosal integrity in the rat. Gastroenterology 81:335-339.
32. Sreebny LM (1996). Xerostomia: Diagnosis, management and clinical complications. In: Edgar WM and O'Mullan DM, editors. Saliva and oral health. 2nd ed. London: British Dental Association, 43-66.
33. Taichman NS, Young S, Cruchley A, Taylor P, and Paleolog E (1997). Human neutrophils secrete vascular endothelial growth factor. J Leukoc Biol 62:397-400.
34. Terman BI, Vermazen MD, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, and Bohlen P (1992). Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Commun 34:1578-1586.
35. Thesleff I, Viinikka L, Saxen L, Lehtonen E, and Perheentupa J (1988). The parotid gland is the main source of human salivary epidermal growth factor. Life Sci 43:13-18.
36. Towbin H, Staehelin T, and Gordon J (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
37. Unemori EN, Ferrara N, Bauer EA, and Amento EP (1992). Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153:557-562.
38. van der Zee R, Murohara T, Iuo Z, Zollman F, Passen J, Lekutat C, and Isner JM (1997). Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95:1030-1037.
39. Zelles T, Purushotham KR, Macauley SP, Oxford GE, and Humphreys-Behr MG (1995). Saliva and growth factors: The fountain of youth resides in us all. J Dent Res 74:1826-1832.