Hypothesis: Cis-unsaturated fatty acids as potential anti-peptic ulcer drugs

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 58, Issue 5, 1998, Pages 377-380

  Das, U N ^a  

^a L V PRASAD EYE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTACID AGENT; ANTIBIOTIC AGENT; CHOLESTEROL; DIHOMO GAMMA LINOLENIC ACID; DOCOSAHEXAENOIC ACID; FAMOTIDINE; GAMMA LINOLENIC ACID; GASTRIN RELEASING PEPTIDE; HISTAMINE H2 RECEPTOR ANTAGONIST; ICOSAPENTAENOIC ACID; LINOLENIC ACID; OLEIC ACID; PENTAGASTRIN; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; PROTON PUMP INHIBITOR; STEROID; TRIACYLGLYCEROL;

ARTICLE; ATHEROSCLEROSIS; CYTOTOXICITY; DUODENUM ULCER; ESSENTIAL FATTY ACID DEFICIENCY; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HYPOTHESIS; PEPTIC ULCER; PRIORITY JOURNAL; STOMACH ACID SECRETION; TUMOR CELL; ULCER HEALING;

ANIMALIA; HELICOBACTER PYLORI; NEGIBACTERIA;

EID: 0031871159     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-3278(98)90074-6     Document Type: Article

References (31)

1. Alper J. Ulcers are an infectious disease. Science 1993; 260: 159-160.
2. Taylor I. L, Calam J., Rotter J., et al. Family studies of hypergastrinaemic, hyperpepsinogenaemic I duodenal ulcer disease. Ann Intern Med 1981; 95: 421-425.
3. Walsh J. H., Richardson C. T., Fordtran J. S. pH dependence of acid secretior and gastrin release in normal and ulcer subjects. J Clin Invest 1975; 55: 462-468.
4. Baron J. H., Clinical tests of gastric secretion. London: MacMillan Press, 1978.
5. Levi S., Bearshall K, Haddad G., Playford R., Ghosh P., Calam J. Campylobacter pylori and duodenal ulcers: The gastrin link. Lancet 1989; 339: 1167-1168.
6. Price A. B., Levi J., Dolby J. M., et al. Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut 1985; 26: 1183-1186.
7. Johnson L R. The trophic action of gastrointestinal hormones. Gastroenterology 1976; 70: 278-282.
8. El-Omar E., Fennun L, Dorrian C. A., Ardill J. F. S., McColl K. E. L. Eradicating Helicobacter pylori infection lowers gastrin-mediated acid secretion by two-thirds in duodenal ulcer patients. Gut 1993; 34: 1060-1065.
9. Moss S. F., Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: Effect of eradication of Helicobacter pylori. Gut 1993; 34: 888-892.
10. Kramling H. J., Enders G., Teichmann R. K., Demmel T., Merkle R., Brendel W. Antigen-induced gastrin release: an immunologic mechanism of gastric antral mucosa. Adv Exp Med Biol 1987; 216A: 427-429.
11. Moss S. F., Legon S., Bishop A. E., Polak J. M., Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet 1992; 340: 930-932.
12. Card W. I., Marks I. N. The relationship between the acid out put of the stomach following "maximal" histamine stimulation and the parietal cell mass. Clin Sci 1960; 19: 147-163.
13. Dixon M. Acid, ulcers and H. pylori. Lancet 1993; 342: 384-385.
14. Hollander D., Tarnawski A. Dietary essential fatty acids and the decline in peptic ulcer disease - a hypothesis. Gut 1986; 27: 239-242.
15. Robert A., Nezamis J. E., Lancaster C., Hanchar A. J. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433-443.
16. Grant H. W., Palmer K. R., Kellt R. W., Wilson N. H., Nisiewicz J.J. Dietary linoleic acid, gastric acid and prostaglandin secretion. Gastroenterology 1988; 94: 955-959.
17. Miller T. Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am J Physiol 1983; 245: G601-G623.
18. Das U. N., Reddy G. N., Rao P. N, Radha V. Essential fatty acids and peptic ulcer disease. Gut 1987; 28: 914-915.
19. Das U. N., Reddy G. N., Rao P. N., Radha V. Essential fatty acids and peptic ulcer disease. Gut 1988; 29: 134.
20. Das U. N., Vijay Kumar K., Ramanjaneyulu E., Joshi N., Dixit V. K. Essential fatty acids and their metabolites in duodenal ulcer. Med Sci Res 1994; 22: 423-425.
21. Thompson L, Cockayne A., Spiller R. C. Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. Gut 1994; 35: 1557-1561.
22. Knapp H. R., Molly M. A. Bactericidal effects of polyunsaturated fatty acids. J Infect Dis 1986; 154: 84-94.
23. Wyss O., Ludwig B. J., Joiner R. R. The fungistatic and fungicidal action of fatty acids and related compounds. Arch Biochem 1945; 7: 415-425.
24. Lees A. M., Korn E. D. Metabolism of unsaturated fatty acids in protozoa. Biochemistry 1966; 15: 1475-1481.
25. Das U. N. Antibiotic-like action of essential fatty acids. Can Med Assoc J 1985; 123: 1350.
26. Sands J. A. Inactivation and inhibition of replication of the enveloped bacteriophage 06 by fatty acids. Antimicrob Agents Chemother 1977; 12: 523-530.
27. Das U. N., Devi G. R, Rao K. P., Rao M. S. Prostaglandins can modify gamma-radiation and chemical-induced cytotoxicity and genetic damage both in vitro and in vivo. Prostaglandins 1989; 38: 689-716.
28. Das U. N. Effect of epiderma growth factor on fatty acid uptake in normal and tumor cells in vitro. Med Sci Res 1992; 19: 639-641.
29. Das U. N. Tumoricidal action of cis-unsaturated fatty acids and its relationship to free radicals and lipid peroxidation. Cancer Lett 1991; 56: 235-243.
30. Das U. N, Prasad V. V. S. V., Reddy D. R. Local application of gamma-linolenic acid in the treatment of human gliomas. Cancer Lett 1995; 94: 147-155.
31. Huang Y. S., Drummond R., Horrobin D. F. Protective effect of gamma-linolenic acid on aspirin-induced gastric haemorrhage in rats. Digestion 1987; 36: 36-41.