Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline

American Journal of Psychiatry

Volumn 155, Issue 8, 1998, Pages 1110-1112

  Pollock, Bruce G ^a,b   Mulsant, Benoit H ^a   Nebes, Robert ^a   Kirshner, Margaret A ^a   Begley, Amy E ^a   Mazumdar, Sati ^a   Reynolds III, Charles F ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NORTRIPTYLINE; PAROXETINE;

ADULT; AGING; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DELIRIUM; DEPRESSION; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; ELDERLY CARE; HUMAN; MAJOR CLINICAL STUDY; MEMORY; PRIORITY JOURNAL; QUALITY OF LIFE; RATING SCALE; TACHYCARDIA;

EID: 0031870925     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.8.1110     Document Type: Article

References (11)

1. Feinberg M: The problems of anticholinergic adverse effects in older patients. Drugs Aging 1993; 3:335-348
2. Tune LE, Damlouji NF, Holland AF, Gardner TJ, Folstein MF, Coyle JT: Association of postoperative delirium with raised levels of anticholinergic drugs. Lancet 1981; 2:651-653
3. Miller PS, Richardson JS, Jyu CA, Lemay JS, Hiscock M, Keegan DL: Association of low serum anticholinergic levels and cognitive impairment in elderly presurgical patients. Am J Psychiatry 1988; 145:342-345
4. Rovner BW, David A, Lucas-Blaustein MJ, Conklin B, Filipp L, Tune L: Self-care capacity and anticholinergic drug levels in nursing home patients. Am J Psychiatry 1988; 145:107-109
5. Richelson E: Synaptic effects of antidepressants. J Clin Psychopharmacol 1996; 16(suppl 2):1S-9S
6. Cusak B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) 1994; 114:559-565
7. Tune L, Coyle JT: Serum levels of anticholinergic drugs in the treatment of acute extrapyramidal side effects. Arch Gen Psychiatry 1980; 37:293-297
8. Pollock BG, Everett G, Peril J: Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites. Neuropsychopharmacology 1992; 6:1-10
9. Foglia JP, Sorisio D, Kirshner M, Pollock BG: Quantitative determination of paroxetine in plasma by high-performance liquid chromatography and ultraviolet detection. J Chromatogr Biol Med Appl 1997; 693:147-151
10. Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K: The UKU Side Effect Rating Scale: a new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl 1987; 334:1-100
11. SAS User's Guide: Statistics, version 6. Cary, NC, SAS Institute, 1990