Insulin receptor exon 11+/- isoform mRNA in spontaneously hypertensive and adrenocorticotropin-hypertensive rats

Journal of Hypertension

Volumn 16, Issue 7, 1998, Pages 1009-1014

  Lou, Yi Kun ^a   Zee, Robert Y L ^a   Li, Ming ^b   Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

Author keywords

Adrenocorticotropin induced hypertension; Differential splicing; Insulin receptor; Messenger RNA; Polymerase chain reaction; Reverse transcription; Spontaneously hypertensive rat

Indexed keywords

CORTICOTROPIN; INSULIN RECEPTOR; ISOPROTEIN; MESSENGER RNA;

ADIPOSE TISSUE; ADRENAL GLAND; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DOT HYBRIDIZATION; EXON; HEART; HUMAN TISSUE; HYPERTENSION; HYPOTHALAMUS; INSULIN RESISTANCE; KIDNEY; LIVER; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SPONTANEOUSLY HYPERTENSIVE RAT; TISSUE LEVEL;

EID: 0031870696     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816070-00015     Document Type: Article

References (42)

1. Flack JM, Sowers JR. Epidemiological and clinical aspects of insulin resistance and hyperinsulinemia. Am J Med 1991: 91 (suppl 1A): 11S-21S.
2. Allemann Y, Horber FF, Colombo M, Ferrari P, Shaw S, Jaeger P, et al. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 1993; 341:327-331.
3. Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Otsuka K, Saruta T. Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism. J Hypertens 1993; 11:421-426.
4. Rao RH. Insulin resistance in spontaneously hypertensive rats. Difference in interpretation based on insulin infusion rate or on plasma insulin in glucose clamp studies. Diabetes 1993; 42:1364-1371.
5. Swislocki A, Tsuzuki A. Insulin resistance and hypertension: glucose intolerance. hyperinsulinaemia, and elevated free fatty acids in the lean spontaneously hypertensive rat. Am J Med Sci 1993; 306:282-286.
6. Zimlichman R, Matas Z, Gass S, Shaher C, Barg J, Nakash I, et al. Hyperinsulinaemia increases blood pressure in genetically predisposed spontaneously hypertensive rats. J Hypertens 1995; 13:1009-1013.
7. Mondon CE, Reavan GM, Azhar S, Lee CM, Rabkin R. Abnormal insulin metabolism by specific organs from rats with spontaneous hypertension. Am J Physiol 1989; 257:E491-E498.
8. Kahn CR, Saad MJA. Alterations in insulin receptor and substrate phosphorylation in hypertensive rats. J Am Soc Nephrol 1992; 3:S69-S77.
9. Sechi LA, Griffin CA, Sechi G, De Carli S, Bartoli E, Expression of the insulin receptor gene in liver and kidney of rats with genetic hypertension. J Hypertens 1993; 11 (suppl 5):S68-S69.
10. Sechi LA, Griffin CA, Giaccetti G, Zingaro L, Catena C, Bartoli E, Schambelan M. Abnormalities of insulin receptors in spontaneously hypertensive rats. Hypertension 1996; 27:955-961.
11. Sanchez-Margalet V, Valle M, Lobón JA, Maldonado A, Escobar F, Pérez R, et al. Diminished insulin receptors on erythrocyte ghosts in nonobese patients with essential hypertension independent of hyperinsulinemia. J Cardiovasc Pharmacol 1994; 24:74-77.
12. Goldstein BJ, Dudley AL, The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing, Mol Endocrinol 1990; 4:235-244.
13. Seino S, Bell GI. Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Commun 1989; 159: 312-316.
14. Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA, Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 1990; 9:2409-2413.
15. Sesti G, Tullio AN, D'Alfonso R, Napolitano ML, Marini MA, Borboni P, et al. Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein. Acta Diabetol 1994; 31:59-65.
16. McClain DA. Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action. Mol Endocrinol 1991; 5:734-739.
17. Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE, Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology 1991; 129:2058-2066.
18. Kellerer M, Machicao F, Seffer E, Mushack J, Ullrich A, Häring U. Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor. Biochem Biophys Res Commun 1991; 181:566-572.
19. Kellerer M, Lammers R, Ermel B, Tippmer S, Vogt B, Obermaier-Kusser B, et al. Distinct α-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry 1992; 31:4588-4596.
20. Breiner M, Weiland M, Becker W, Mullerweiland D, Streicher R, Fabry M, et al. Heterogeneity of insulin receptors in rat tissues as detected with the partial agonist B29.B29′-suberoyl-insulin. Mol Pharmacol 1993; 44:271-276.
21. Joost H-G, Structural and functional heterogeneity of insulin receptors. Cell Signal 1995; 7:85-91.
22. Moller DE, Yokota A, Caro JF, Flier JS, Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol Endocrinol 1989; 3:1263-1269.
23. Vogt B, Carrascosa JM, Ullrich A, Häring H. The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem Biophys Res Commun 1991; 177:1013-1018.
24. Yamaguchi Y, Flier JS, Benecke H, Ransil BJ, Moller DE. Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 1993; 132:1132-1138.
25. Sell SM, Reese D, Ossowski VM. Insulin-inducible changes in insulin receptor mRNA splice variants. J Biol Chem 1994; 269:30769-30772.
26. Kosaki A, Webster NJG, Effect of dexamethasone on the alternative splicing of the insulin receptor messenger RNA and insulin action in HepG2 hepatoma cells. J Biol Chem 1993; 268:21990-21996.
27. Norgren S, Li LS, Luthman H. Regulation of human insulin receptor RNA splicing in HepG2 cells - effects of glucocorticoid and low glucose concentration. Biochem Biophys Res Commun 1994; 199:277-284.
28. Kim YB, Inoe T, Nakajima R, Nakae K, Tamura T, Tokuyama K. et al. Effects of endurance training on gene expression of insulin signal transduction pathway. Biochem Biophys Res Commun 1995; 210: 766-773.
29. Mosthaf L, Vogt B, Häring HU, Ullrich A. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc Natl Acad Sci USA 1991; 88:4728-4730.
30. Sesti G, Marini AA, Tullio AN, Montemurro A, Borboni P, Fusco A, et al. Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem Biophys Res Commun 1991; 181:1419-1424.
31. Mosthaf L, Eriksson J, Häring HU, Groop L, Widen E, Ullrich A. Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes. Proc Natl Acad Sci USA 1993; 90:2633-2635.
32. Norgren S, Zierath J, Galuska D, Wallberg-Henriksson H, Luthman H. Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. Diabetes 1993; 42: 675-681.
33. Benecke H, Flier JS, Moller DE. Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest 1992; 89:2066-2070.
34. Hansen T, Bjørbæk C, Vestergaard H, Grønskov K, Bak JF, Pedersen O. Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus. J Clin Endocr Metab 1993; 77:1500-1505.
35. Haring HU, Kellerer M, Mosthaf L. Modulation of insulin signalling in non-insulin-dependent diabetes mellitus; significance of altered receptor isoform patterns and mechanisms of glucose-induced receptor modulation. Horm Res 1994; 41:87-92.
36. Huang Z, Bodkin NL, Ortmeyer HK, Zenilman ME, Webster NJG, Hansen BC, et al. Altered insulin receptor mRNA splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey - analysis of controversy between monkey and human studies. J Clin Endocr Metab 1996; 81:1552-1556.
37. Sbraccia P, Dadamo M, Leonetti F, Caiola S, Iozzo P, Giaccari A, et al. Chronic primary hyperinsulinaemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinoma. Diabetologia 1996; 39:220-225.
38. Li M, Wong K-S, Whitworth JA. Influence of somatostatin analogue (SMS 201-995, octreotide) on blood pressure in adrenocorticotrophin (ACTH) treated rats: role of hyperinsulinaemia in ACTH hypertension, Clin Exp Pharmacol Physiol 1993; 20:647-653.
39. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Second edition. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory: 1989.
40. Lou Y-k, Liu DT, Whitworth JA, Morris BJ, Renin mRNA, quantified by polymerase chain reaction, in renal hypertensive rat tissues. Hypertension 1995; 26:656-664.
41. Norgren S, Arner P, Luthman H. Insulin receptor ribonucleic acid levels and alternative splicing in human liver, muscle, and adipose tissue: tissue specificity and relation to insulin action. J Clin Endocr Metab 1994; 78:757-762.
42. Sesti G, Dalfonso R, Punti MDV, Frittitta L, Trischitta V, Liu YY, et al. Peptide-based radioimmunoassay for the two isoforms of the human insulin receptor. Diabetologia 1995; 38:445-453.