Zinc deficiency increases hypothalamic neuropeptide Y and neuropeptide Y mRNA levels and does not block neuropeptide Y-induced feeding in rats

Journal of Nutrition

Volumn 128, Issue 7, 1998, Pages 1218-1223

  Lee, Rita G ^a   Rains, Tia M ^a   Tovar Palacio, Claudia ^a   Beverly, J Lee ^a   Shay, Neil F ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Food intake regulation; Hypothalamus; Neuropeptide Y; Rats; Zinc deficiency

Indexed keywords

MESSENGER RNA; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; FEEDING; HYPOTHALAMUS; MALE; NONHUMAN; RAT; THALAMUS MIDLINE NUCLEUS; ZINC DEFICIENCY;

ANIMALIA;

EID: 0031870167     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.7.1218     Document Type: Article

References (28)

1. Ashley, D.V.M. & Anderson, G. H. (1975) Correlation between the plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. J. Nutr. 105: 1412-1421.
2. Bakan, R. (1984) Anorexia and zinc. Lancet 2: 874.
3. Chesters, J. K. & Quarterman, J. (1970) Effects of zinc deficiency on food intake and feeding patterns of rats. Br. J. Nutr. 24: 1061-1069.
4. Clark, J. T., Kalra, P., Crowley, W. & Karla, S. (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429.
5. Essatara, M. B., Levine, A. S., Morley, J. E. & McClain, C. J. (1984a) Zinc deficiency and anorexia in rats: the effect of central administration of norepinephrine, muscimol, and bromerogocryptine. Physiol. & Behav. 32: 479-482.
6. Essatara, M. B., Morley, J. E., Levine, A. S., Elson, M. K., Shafer, R. B. & McClain, C. J. The role of endogenous opiates in zinc deficiency anorexia (1984b) Physiol. & Behav. 32: 469-474.
7. Griffith, P. R. & Alexander, J. C. (1972) Effect of zinc deficiency on amino acid metabolism of the rat. Nutr. Rep. Int. 6: 9-20.
8. Montgomery, D. C. (1984) Design and Analysis of Experiments, 2nd ed. John Wiley & Sons, New York, NY.
9. O'Dell, B. L. & Reeves, P. G. (1989) Zinc status and food intake. In: Zinc in Human Biology, Vol. 131, pp. 173-181. ILSI Press, Washington, DC.
10. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, Orlando, FL
11. Pekary, A. E., Lukaski, H. C., Mena, I. & Hershman, J. M. (1991) Processing of TRH precursor peptides in rat brain and pituitary is zinc dependent. Peptides 12: 1025-1031.
12. Prasad, A. S. (1985) Clinical manifestations of zinc deficiency. Annu. Rev. Nutr. 5: 341-363.
13. Rains, T. M. & Shay, N. F. (1995) Zinc status specifically changes preferences for carbohydrate and protein in rats selecting from separate carbohydrate-, protein-and fat-containing diets. J. Nutr. 125: 2874-2879.
14. Reeves, P. G., Nielsen, F. H. & Fahey, G. C.. Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 rodent diet. J. Nutr. 123: 1939-1951.
15. Reeves, P. G. & Odell, B. L. (1981) Regulation of protein intake in zinc deficient rats. In: Trace Element Metabolism in Animals and Man (Howell, J. C., Gawthorne, J. M. & White, C. L., eds.), pp. 338-341. Australian Academy of Science, Canberra, Australia.
16. Sahu, A., Kalra, P. S. & Kalra, S. P. (1988) Food deprivation and ingestion induced reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9: 83-86.
17. Sahu, A., White, J. D., Kalra, P. S. & Kalra, S. P. (1992) Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen. Mol. Brain Res. 15: 15-18.
18. Schwartz, T. W., Fuhlendorff, J., Kjems, L. L., Kristensen, M. S., Vervelde, M., O'Hare, M., Kretenansky, J. L. & Bjornholm, B. (1990) Signal epitopes in the three-dimensional structure of NPY interaction with the Y1, Y2, and PP receptors. Ann. N.Y. Acad. Sci. 611: 35-47.
19. Selvais, P. L., Labuche, C., Ninh, N. X., Ketelslegers, J.-M., Denef, J.-F. & Maiter, D. M. (1997) Cyclic feeding behavior and changes in hypothalamic galanin and neuropeptide Y gene expression induced by zinc deficiency in the rat. J. Neuroendocrinol. 9: 55-62.
20. Shay, N. & Cousins, R. J. (1993) Cloning of rat intestinal mRNAs affected by zinc deficiency. J. Nutr. 123: 35-41.
21. Stanley, B. G., Daniel, D. R., Chin, A. S. & Leibowitz, S. F. (1985) Paraventricular mucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6: 1205-1211.
22. Stanley, B. G., Kyrkouli, S. E., Lampert, S. & Leibowitz, S. F. (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189-1192.
23. Stanley, B. G. & Leibowitz, S. F. (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U.S.A. 82: 3940-3943.
24. Tamaki, N., Fujimoto-Sakata, S., Kikugawa, M., Kaneko, M., & Onosaka, S. (1995) Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC3.5.2.2). Br. J. Nutr. 73: 711-722.
25. Tovar-Palacio, C., Cole, A. C., Mangian, H. & Shay, N. F. (1996) In vitro secretion and in-situ expression of hypothalamic neuropeptide y during zinc deficiency. Soc. Neurosci. Abstr. 22: 184.13.
26. Wallwork, J. C., Botnen, J. H. & Sandstead, H. H. (1982) Influence of dietary zinc on rat brain catecholamines. J. Nutr. 112: 514-519.
27. Welch, C. C., Grace, M. K., Billington, C. J. & Levine, A. S. (1994) Preference and diet type affect macronutrient selection after morphine, NPY, norepinephrine, and deprivation. Am. J. Physiol. 266: R426-R433.
28. Wilding, J.P.H., Gilbey, S. G., Mannan, M., Aslam, N., Ghatei, M. A. & Bloom, S. R. (1991) Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats. J. Endocrinol. 132: 299-304.