cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro

Mediators of Inflammation

Volumn 7, Issue 3, 1998, Pages 195-199

  Bug, G ^a   Aman, J ^a   Huber, C ^a   Peschel, C ^a   Derigs, H G ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Bone marrow stromal cells; c AMP; GM CSF; IL 1

Indexed keywords

CYCLIC AMP; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOMETACIN; INTERLEUKIN 1;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECT; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYME CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STEM CELL; STROMA CELL; SUPERNATANT;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; BONE MARROW CELLS; CELLS, CULTURED; CYCLIC AMP; DINOPROSTONE; DOWN-REGULATION; FORSKOLIN; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; RNA, MESSENGER; STROMAL CELLS;

EID: 0031869561     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/09629359891135     Document Type: Article

References (27)

1. Kittler EL, McGrath H, Temeles D, Crittenden RB, Kister VK, Quesenberry PJ. Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Blood 1992; 79: 3168-3178.
2. Frei K, Piani D, Malipiero UV, Van Meir E, de Tribolet N, Fontana A. Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells. Despite the presence of inducing signals GM-CSF is not expressed in vivo. J Immunol 1992; 148: 3140-3146.
3. Wang Q-R, Wolf NS. Dissecting the hematopoietic microenvironment. VIII. Clonal isolation and identification of cell types in murine CFU-F colonies by limiting dilution. Exp Hematol 1990; 18: 355-359.
4. Slack JL, Nemunaitis J, Andrews DF III, Singer JW. Regulation of cytokine and growth factor gene expression in human bone marrow stromal cells transformed with simian virus 40. Blood 1990; 75: 2319-2327.
5. Gimble JM, Pietrangeli A, Dorheim MA, Silver J, Namen A, Takeichi M, Goridis C, Kincade PW. Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels. Blood 1989; 74: 303-311.
6. Anderson DM, Lyman SD, Baird A, Wignall JM, Eisenman J, Rauch C, March CJ, Boswell HS, Gimpel SD, Cosman D, Williams DE. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 1990; 63: 235-243.
7. Aman MJ, Rudolf G, Goldschmitt J, Aulitzky WE, Lam C, Huber C, Peschel C. Type I interferons are potent inhibitors of interleukin-8 production in hematopoetic and bone marrow stromal cells. Blood 1993; 82: 2371.
8. Asubel FM, Brent R, Kingston RE, Current Protocols in Molecular Biology. New York: Wiley, 1987.
9. Deschaseaux ML, Herve P, Charbord P. The detection of colonystimulating factors and steel factor in adherent layers of human long-term marrow cultures using reverse-transcriptase polymerase chain reaction. Leukemia 1994; 8: 513-519.
10. Aman MJ, Keller U, Derigs G, Mohammadzadeh M. Huber C, Peschel C. Regulation of cytokine expression by interferon alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of IL-1 receptor antagonist. Blood 1994; 84: 4142-4150.
11. Caldwell J, Emerson SG. IL-1 alpha and TNF alpha act synergistically to stimulate production of myeloid colony-stimulating factors by cultured human bone marrow stromal cells and cloned stromal cell strains. J Cell Physiol 1994; 159: 221-228.
12. Guba SC, Sartor CI, Gottschalk LR, Jing YH, Mulligan T, Emerson SG. Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte-macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by serum-free bioassay, enzyme-linked immunosorbent assay, and reverse transcriptasc polymerase chain reaction. Blood 1992; 80: 1190-1198.
13. Charbord P, Tamayo E, Saeland S, Duvert V, Poulet J, Gown AM, Herve P. Granulocyte-macrophage colony-stimulating factor (GM-CSF) in human long-term bone marrow cultures: Endogeneous production in the adherent layer and effect of exogeneous GM-CSF on granulomonopoiesis. Blood 1991; 78: 1230-1236.
14. Kasahara T, Yagisawa H, Yamashita K, Yamaguchi Y, Akiyama Y. IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP. Biochem Biophys Res Commun 1990; 167: 1242-1248.
15. Gimble JM, Hudson J, Henthorn J, Hua XX, Burstein SA. Regulation of interleukin 6 expression in murine bone marrow stromal cells. Exp Hematol 1991; 19: 1055-1060.
16. Derigs HG, Boswell HS, LIF mRNA expression is transcriptionally regulated in murine bone marrow stromal cells Leukemia 1993; 7: 630-634.
17. Sherman ML, Weber BL, Datta R, Kufe DW. Transcriptional and posttranscriptional regulation of macrophage-specific colony stimulating factor gene expression by tumor necrosis factor. Involvement of arachidonic acid metabolites. J Clin Invest 1990; 85: 442-447.
18. Abboud SL. Regulation of platelet-derived growth factor A and B chain gene expression in bone marrow stromal cells J Cell Physiol 1995; 164: 434-440.
19. Knudsen PJ, Dinarello CA, Storm TB, Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol 1986; 10: 3189-3194.
20. Derigs HG, Burgess GS, Klingberg D, Nahreini TS, Mochizuki DY, Williams DE, Boswell HS. Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production. Leukemia 1990; 4: 471-479.
21. Derigs HG, Reifel-Miller A, Kaushansky K, Hromas RA, Boswell HS. GM-CSF expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line. Exp Hematol 1994; 22: 924-932.
22. Scutt A, Zeschnigk M, Bertram P. PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism. Prostaglandins 1995; 49: 383-395.
23. Hamilton JA, Piccoli DS, Cebon J, Layton JE, Rathanaswani P, McColl SR, Leizer T. Cytokine regulation of colony-stimulating factor (CSF) production in cultured human synovial fibroblasts. II. Similarities and differences in the control of interleukin-1 induction of granulocyte-macro-phage CSF and granulocyte-CSF production. Blood 1992; 79: 1413-1419.
24. Patil RR, Borch RF. Granulocyte-macrophage colony-stimulating factor expression by human fibroblasts is both upregulated and subsequently downregulated by interleukin-1. Blood 1995; 85: 80-86.
25. Pelus LM, Gentile PS. In vivo modulation of myelopoesis by prostaglandin E2. III. Induction of suppressior cells in marrow and spleen capable of mediating inhibition of CFU-GM proliferation. Blood 1988; 71: 1633-1640.
26. Gentile P, Byer D, Pelus LM. In vivo modulation of murine myelopoesis following intravenous administration of prostaglandin E2. Blood 1983; 62; 1100-1107.
27. Gentile PS, Pelus LM. In vivo modulation of myelopoiesis by prostaglandin E2. IV. Prostaglandin E2 induction of myelopoietic inhibitory activity. J Immunol 1988; 141: 2714-2720.