Screening of epiphytic dinoflagellates for radical scavenging and cytotoxic activities

Phycological Research

Volumn 46, Issue SUPPL., 1998, Pages 9-12

  Nakagawa, Hidenori ^a   Murata, Michio ^a   Tachibana, Kazuo ^a   Shiba, Tadayoshi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Antioxidant; Coolia; Cytotoxin; Dinoflagellate; Epiphytic algae; Gambierdiscus; Gymnodinium; Lipid peroxide; Radical scavenger

Indexed keywords

COOLIA MONOTIS; GAMBIERDISCUS TOXICUS; GYMNODINIUM; PROROCENTRUM;

EID: 0031869431     PISSN: 13220829     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1835.1998.tb00264.x     Document Type: Article

References (16)

1. Bender, A. D., Kormends, C. G. and Powell, P. 1970. Pharmacological control of aging. Exp. Gerontol. 5: 97-129.
2. Bewley, C. A., Holland, N. D. and Faulkner, D. J. 1996. Two classes of metabolites from Theonella swinhoei and localized in distinct populations of bacterial symbionts. Experientia 52: 716-22.
3. Bitterman, N., Melamed, Y. and Ben-Amotz, A. 1994. Beta-carotenes and CNS oxygen toxicity in rats. J. Appl. Physiol. 76: 1073-6.
4. Carmely, S. and Kashman, Y. 1985. Structure of swinholide-A, a new macrolide from the marine sponge Theonella swinhoei. Tetrahedron Lett. 26: 511-14.
5. 6 from Ptychodiscus brevis (formerly Gymnodinium breve) enhances activation of voltage-sensitive sodium channels by veratridine. Mol. Pharmacol. 19: 345.
6. Kobayashi, M., Aoki, S., Sakai, H. et al. 1993. Altohyrtin A, a potent anti-tumor macrolide from the Okinawan marine sponge Hyrtios altum. Tetrahedron Lett. 34: 2795.
7. Lin, Y.-Y., Risk, M., Ray, S. M. et al. 1981. Isolation and structure of brevetoxin B from the 'red tide' dinoflagellate Ptychodiscus brevis (Gymnodinium breve). J. Am. Chem. Soc. 103: 6773-5.
8. Murakami, Y., Oshima, Y. and Yasumoto, T. 1982. Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima. Bull. Jpn. Soc. Sci. Fish. 48: 69-72.
9. Murata, M., Naoki, H., Matsunaga, S., Satake, M. and Yasumoto, T. 1994. Structure and partial stereochemical assignments for maitotoxin, the most toxic and largest natural non-biopolymer. J. Am. Chem. Soc. 116: 7098-107.
10. Shimizu, Y., Chou, H.-H., Bando, H., Duyne, G. V. and Clardy, J. C. 1986. Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the floride red tide organism Gymnodinium breve (Ptychodiscus brevis). J. Am. Chem. Soc. 108: 514-15.
11. Tachibana, K., Scheuer, P. J., Tsukitani, Y. et al. 1981. Okadaic acid, a cytotoxic polyether from two marine sponge of the genus Halichondria. J. Am. Chem. Soc. 103: 2469-70.
12. 2+ channel activator candidate. J. Biol. Chem. 257: 7287-9.
13. Takai, A., Bialojan, C., Troschka, M. and Ruegg, J. C. 1988. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEBS Lett. 217: 81-4.
14. 2+ and ascorbic acid induced oxidation of cholesterol in phosphatidylcholine liposomes and its inhibition by α-tocopherol. J. Nutr. Sci. Vitaminol. 31: 499-508.
15. Terao, K. and Niki, E. 1986. Damage to biological tissues induced by radical initiator 2, 2′-azobis (2-amidinopropane) dihydrochloride and its inhibition by chain-breaking antioxidants. J. Free Radicals Biol. Med. 2: 193-201.
16. Uchiyama, M. and Mihara, M. 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Chem. 86: 271-8.