Therapeutic drug monitoring of clozapine treatment. Therapeutic threshold value for serum clozapine concentrations

Clinical Pharmacokinetics

Volumn 34, Issue 6, 1998, Pages 497-502

  Olesen, Ole Vendelin ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE;

ARTICLE; CONFUSION; DRUG BLOOD LEVEL; DRUG MONITORING; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOSIS; RECEPTOR OCCUPANCY; SEIZURE;

ANTIPSYCHOTIC AGENTS; CLOZAPINE; DRUG MONITORING; HUMANS; MAXIMUM ALLOWABLE CONCENTRATION;

EID: 0031867860     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199834060-00005     Document Type: Article

References (20)

1. Freeman DJ, Oyewumi LK. Will routine therapeutic drug monitoring have a place in clozapine therapy? Clin Pharmacokinet 1997 Feb; 32 (2): 93-100
2. Perry PJ, Miller DD, Arndt SV, et al. Clozapine and nor-clozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry 1991; 148: 231-5
3. Miller DD, Fleming F, Holman TL, et al. Plasma clozapine concentrations as a predictor of clinical response: a follow-up study. J Clin Psychiatry 1994; 55 (9 Suppl. B): 117-21
4. Potkin SG, Bera R, Gulasekaram B, et al. Plasma clozapine concentrations predict clinical response in treatment-resistant schizophrenia. J Clin Psychiatry 1994; 55 (9 Suppl. B): 133-6
5. Kronig MH, Munne RA, Szymanski S, et al. Plasma clozapine levels and clinical response for treatment-refractory schizophrenic patients. Am J Psychiatry 1995; 152 (2): 179-82
6. Hasegawa M, Gutierrez-Esteinou R, Way L, et al. Relationship between clinical efficacy and clozapine concentrations in plasma in schizophrenia: effect of smoking. J Clin Psychopharmacol 1993; 13 (6): 383-90
7. Olesen OV, Licht RW. A naturalistic study of clozapine serum concentrations in psychiatric patients. Nord J Psychiatry 1996; 50 (5): 413-8
8. Choc MG, Lehr RG, Hsuan F, et al. Multi-dose pharmacokinetics of clozapine in patients. Pharm Res 1987; 4: 402-5
9. Oyewumi LK, Freeman DJ, Vollick D. Can low-dose clozapine pharmacokinetics predict steady-state plasma concentration? Ther Drug Monit 1995 Apr; 17 (2): 137-41
10. Naber D, Holzbach R, Perro C, et al. Clinical management of clozapine patients in relation to efficacy and side-effects. Br J Psychiatry 1992, 160 Suppl. 17: 54-9
11. Fleischhacker WW, Hummer M, Kurz M, et al. Clozapine dose in the United States and Europe: implications for therapeutic and adverse effects. J Clin Psychiatry 1994 Sept; 55 (9 Suppl. B): 78-81
12. Lieberman JA, Safferman AZ, Pollack S, et al. Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome. Am J Psychiatry 1994; 151: 1744-52
13. Meltzer HY. Utilization, multidimensional outcome measures, and risk-benefit considerations for the use of clozapine in schizophrenia. In: Brunello N, Mendlewicz J, Racagni G, editors. New generation of antipsychotic drugs: novel mechanisms of action. Int Acad Biomed Drug Res 199; 4: 103-17
14. Owen JA, Delva NJ, Lawson JS. Clozapine concentrations and clinical response in schizophrenic patients [letter]. Am J Psychiatry 1992 Aug; 149 (8): 1120-1
15. VanderZwaag C, McGee M, McEvoy JP, et al. Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges. Am J Psychiatry 1996 Dec; 153 (12): 1579-80
16. Nordström A-L, Farde L, Nyberg S, et al. D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients. Am J Psychiatry 1995 Oct 152 (10): 1444-9
17. Olesen OV, Thomsen K, Jensen PN, et al. Clozapine serum levels and side-effects during steady-state treatment of schizophrenic patients: a cross-sectional study. Psychopharmacology 1995; 117 (3): 371-8
18. Jerling M, Lindström L, Bondesson U, et al. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine. Ther Drug Monit 1994; 16: 368-74
19. Szymanski S, Lieberman SA, Picou D, et al. A case report of cimetidine-induced clozapine toxicity. J Clin Psychiatry 1991; 52: 21-2
20. Olesen OV, Starup G, Linnet K. Serious drug interaction between clozapine-Leponex and fluvoxamine-Fevarin [in Danish]. Ugeskr Laeger 1996 Nov 25; 158 (48): 6931-2