Hypothesis: Ligand/Receptor-Assisted Nuclear Translocation of STATs

Experimental Biology and Medicine

Volumn 218, Issue 3, 1998, Pages 149-155

  Johnson, Howard M ^a   Torres, Barbara A ^a   Green, Marino M ^a   Szente, Brian E ^b   Siler, Kendra I ^a   Larkin III, Joseph ^a   Subramaniam, Prem S ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CELL NUCLEUS; CELLULAR DISTRIBUTION; HUMAN; HYPOTHESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CELL NUCLEUS; DNA-BINDING PROTEINS; HUMANS; INTERFERON TYPE II; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RECEPTORS, INTERFERON; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0031867803     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-218-44282     Document Type: Review

References (64)

1. Leaman DW, Leung S, Li X, Stark GR. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J 10:1578-1588, 1996.
2. Gorlich D, Mattaj IW. Nucleocytoplasmic transport. Science 271:1513-1518, 1996.
3. Dingwall C, Laskey RA. Nuclear targeting sequences: A consensus? Trends Biochem Sci 16:478-481, 1991.
4. Sekimoto T, Nakajima K, Tachibana T, Hirano T, Yoneda Y. Interferon-γ-dependent nuclear import of STAT1 is mediated by the GTPase activity of Ran/TC4. J Biol Chem 271:31017-31020, 1996.
5. Eguchi H, Ikuta T, Tachibana T, Yoneda Y, Kawajiri K. A nuclear localization signal of human aryl hydrocarbon translocation/hypoxia inducible factor 1β is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. J Biol Chem 272:17640-17647, 1997.
6. MacDonald HS, Kushnaryov VM, Sedmak JJ, Grossberg SE. Transport of γ-interferon into the cell nucleus may be mediated by nuclear membrane receptors. Biochem Biophys Res Commun 138:254-260, 1986.
7. Bader T, Wietzerbin J. Nuclear accumulation of interferon γ. Proc Natl Acad Sci USA 91:11831-11835, 1994.
8. Wetzel R, Perry LJ, Veilleux C, Chang G. Mutational analysis of the C-terminus of human interferon-γ. Protein Eng 3:611-623, 1990.
9. Lundell D. Lunn C, Dalgarno D, Fossetta J, Greenberg R, Reim R, Grace M, Narula S. The carboxy-terminal region of human Interferon-γ is important for biological activity: Mutagenic and NMR analysis. Protein Eng 4:335-341, 1991.
10. Dobeli H, Gentz R, Jucker W, Garotta G, Hartmann DW, Hochuli E. Role of the carboxy-terminal sequence on the biological activity of human interferon (IFN-γ). J Biotechnol 7:199-216, 1988.
11. Fidler U, Fogler WE, Kleinerman ES, Saiki I. Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-γ encapsulated in liposomes. J Immunol 135:4289-4296, 1985.
12. Sanceau J. Sondermeyer P, Beranger F, Falcoff R, Vaquero C. Intracellular human interferon-γ triggers an antiviral state in transformed murine L cells. Proc Natl Acad Sci USA 84:2906-2910, 1987.
13. γ J Immunol 144:1777-1782, 1990.
14. Rutherford MN, Kumar A, Coulombe B, Skup D, Carver DH, Williams BRG. Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection. J Interferon Cytokine Res 16:507-510, 1996.
15. Russell JK, Hayes MP, Carter JM, Torres BA, Dunn BM, Russell SW, Johnson HM. Epitope and functional specificity of monoclonal antibodies to mouse interferon-γ. The synthetic peptide approach. J Immunol 136:3324-3328, 1986.
16. Russell JK, Magazine HI, Torres BA, Johnson HM. Steric relationship of amino-terminal and carboxy-terminal domains of murine interferon-γ as assessed by monoclonal antibodies. J Interferon Cytokine Res 8:433-439, 1988.
17. Jarpe MA, Johnson HM. Structure of an epitope in an immunodominant region of the interferon-γ molecule that is involved in receptor interaction. J Interferon Cytokine Res 10:243-252, 1990.
18. γ J Immunol 145:3304-3309, 1990.
19. γ receptor. J Immunol 149:517-520, 1992.
20. γ and its C-terminal peptide to a cytoplasmic domain of its receptor that is essential for function. Biochem Biophys Res Commun 201:215-221, 1994.
21. γ has been identified using the synthetic peptide approach. J Immunol 151:6206-6213, 1993.
22. γ Biochem Biophys Res Commun 243:170-176, 1998.
23. γ is sufficient for intracellular function. Biochem Biophys Res Commun 203:1645-1654, 1994.
24. Adam SA, Marr RS, Gerace L. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol 111:807-816, 1990.
25. Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK. Crystal structure of a complex between interferon-γ and its soluble high affinity receptor. Nature 376:230-235, 1995.
26. Sakai TT, Jablonsky MJ, DeMuth PA, Krishna NR, Jarpe MA, Johnson HM. Proton NMR sequence specific assignments and secondary structure of a receptor binding domain of mouse γ-interferon. Biochemistry 32:5650-5655, 1993.
27. Schreiber RD, Aguet M. The interferon-γ receptor. In: Nicola NA, Ed. Guidebook to Cytokines and their Receptors. Oxford: Oxford University Press, p 120, 1994.
28. Kaplan DH, Greenlund AC, Tanner JW, Shaw AS, Schreiber RD. Identification of an interferon-γ receptor α chain sequence required for JAK1 binding. J Biol Chem 271:9-12, 1996.
29. γ(95-133). J Immunol 155:5617-5622, 1995.
30. Kotenko SV, Izotova LS, Pollack BP, Mariano TM, Donelly RJ, Muthukumaran G, Cook JR, Garotta G, Silvennoinen O, Ihle JN, Pestka S. Interaction between the components of interferon-γ receptor complex. J Biol Chem 270:20915-20921, 1995.
31. Deuel TF, Kawahara RS. Platelet-derived growth factor. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston: Blackwell Scientific Publications, p300, 1992.
32. Pestka S. Interferon-α. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston, Blackwell Scientific Publications, p3, 1992.
33. Uze G, Lutfalla G, Gresser I. Genetic transfer of a functional human interferon alpha receptor into mouse cells: Cloning and expression of its cDNA. Cell 60:225-234, 1990.
34. Gray PW, Goeddel DV. Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci USA 80:5842-5846, 1983.
35. Gray PW. Interferon-γ. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston: Blackwell Scientific Publications, p.30, 1992.
36. Dower SK. Interleukin-1. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston: Blackwell Scientific Publications, p46, 1992.
37. Tsukada J, Waterman WR, Koyama Y, Webb AC, Auron PE. A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL 1), and IL 6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene. Mol Cell Biol 16:2183-2194, 1996.
38. Sims JE, March CJ Cosman D, Widmer MB, McDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, Friend D, Alpert AR, Gillis S, Urdal DL, Dower SK. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241:585-589, 1988.
39. Ishida N, Kanamori H, Noma T, Nikaido T, Sabe H, Suzuki N, Shimizu A, Honjo T. Molecular cloning and structure of the human interleukin-2 receptor gene. Nucleic Acids Res 13:7579-7589, 1985.
40. Zhnag Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM, Wasik MA. Activation of JAK/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin-2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 93:9148-9153, 1996.
41. Gorman DM, Itoh N, Kitamura T, Schreurs J, Yonehara S, Yahara I, Arai K, Miyajima A. Cloning and expression of a gene encoding an interleukin-3-receptor-like protein: Identification of another member of the cytokine receptor family. Proc Natl Acad Sci USA 87:5459-5463, 1990.
42. Mui AL-F, Wakao H, O'Farrell AM, Harada N, Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166-1175, 1995.
43. Mosley B, Beckman MP, March CJ, Idzerda RL, Gimpel SD, VandenBos T, Friend D, Alpert A, Anderson D, Jackson J, Wignall JM, Smith C, Gallis B, Sims JE, Urdal D, Widmer MB, Cosman D, Park LS. The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane-bound forms. Cell 59:335-348, 1989.
44. Arai N, Nomura D. Villaret D, Malefijt RD, Seiki M, Yoshida M, Minoshima S, Fukuyama R, Maekawa M, Kudoh J, Shimizu N, Yokota K, Abe E, Yokota T, Takebe Y, Arai K. Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. J Immunol 142:274-282, 1989.
45. Misuta TR, Tanabe T, Nakakubo H, Noma T, Honjo T. Molecular cloning and structure of the mouse interleukin-5 gene. Growth Factors 1:51-57, 1988.
46. Azuma C, Tanabe T, Konishi M. Kinashi T, Noma T, Matsuda F, Yaoita Y, Takatsu K, Hammarstrom L, Smith CIE, Severinson E, Honjo T. Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. Nucleic Acids Res 14:9149-9158, 1986.
47. Pazdrak K, Stafford S, Alam R. The activation of the JAK/STAT1 signaling pathway by IL-5 in eosinophils. J Immunol 155:397-402, 1995.
48. Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T. Molecular cloning of a murine IL-6-receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol 148:4066-4071, 1992.
49. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149-1157, 1990.
50. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE, Park LS. Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily. Cell 60:941-951, 1990.
51. van der Plas DC, Smiers F, Pouwels K, Hoefsloot LH, Lowenberg B, Touw IP. Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. Leukemia 10:1317-1325, 1996.
52. Liu Y, Wei SHY, Ho ASY, de Waal Malefyt R, Moore KW. Expression cloning and characterization of a human IL-10 receptor. J Immunol 152:1821-1829, 1994.
53. Wehinger J, Gouilleux F, Groner B, Finke J, Mertelsmann R, Weber-Nordt RM. IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett 394:365-370, 1996.
54. Symes AJ, Rao MS, Lewis SE, Landis SC, Hyman E, Kink JS. Ciliary neutrotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. Proc Natl Acad Sci USA 90:572-576, 1993.
55. Sibley E, Kastelic T, Kelly TJ, Lane MD. Characterization of the mouse insulin receptor gene promoter. Proc Natl Acad Sci USA 86:9732-9736, 1989.
56. Chuang LM, Wang PH, Chang HM, Lee SC. Novel pathway of insulin signaling involving STAT1-alpha in Hep3B cells. Biochem Biophys Res Commun 235:317-320, 1997.
57. Kenner KA, Kusari J, Heidenreich KA. cDNA sequence analysis of the human brain insulin receptor. Biochem Biophys Res Commun 217:304-312, 1995.
58. Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI. Growth hormone receptor and serum binding protein: Purification, cloning, and expression. Nature 330:537-543, 1987.
59. Das M, Manthrasalam R, Samanta A. Epidermal growth factor. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston: Blackwell Scientific Publications, p365, 1992.
60. Crosier PS, Garnick MB, Clark SC. Granulocyte-macrophage colony-stimulating factor. In: Aggarwal BB, Gutterman JU, Eds. Human Cytokines: Handbook for Basic Research. Boston: Blackwell Scientific Publications, p238, 1992.
61. Lobie PE, Mertni H, Morel G, Morales-Bustos O, Norstedt G, Waters MJ. Receptor-mediated nuclear translocation of growth hormone. J Biol Chem 269:21330-21339, 1994.
62. Podlecki DA, Smith RM, Kao M, Tsai P, Huecksteadt T, Brandenburg D, Lasher RS, Jarett L, Olefsky JM. Nuclear translocation of the insulin receptor: A possible mediator of the insulin receptor. J Biol Chem 262:3362-3368, 1987.
63. Grenfell S, Smithers N, Miller K, Solari R. Receptor-mediated endocytosis and nuclear transport of human interleukin 1α. Biochem J 264:813-822, 1989.
64. Jans DA. Nuclear signaling pathways for polypeptide ligands and their membrane receptors? FASEB J 8:841-847, 1994.