Traitement empirique précoce chez des patients neutropéniques en hématologie : Étude comparative randomisée fluconazole versus amphotéricine B/ 5-flucytosine

Hematologie

Volumn 4, Issue 3 SUPPL. 2, 1998, Pages 19-22

  Silling, G ^a   Fegeler, W ^a   Roos, N ^a   Boes, C ^a   Schomaker, R ^a   Essink, M ^a   Buchner Th ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B; ANTIFUNGAL AGENT; CEPHALOSPORIN DERIVATIVE; FLUCONAZOLE; FLUCYTOSINE; GLYCOPEPTIDE; IMIPENEM;

ADULT; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MIXTURE; FEVER; HEMATOLOGIC DISEASE; HUMAN; LEUKEMIA; LUNG DISEASE; MAJOR CLINICAL STUDY; MYCOSIS; NEUTROPENIA; RANDOMIZED CONTROLLED TRIAL;

EID: 0031867460     PISSN: 12647527     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Bodey G, Bueltmann B, Duguid W, et al. Fungal infections in cancer patients : an international autopsy survey. Eurj Clin Microbiol Infect Dis 1992; 11 : 99-109.
2. Donhuijsen K, Pfaffenbach B, Samandari S, Leder LD. Autopsy results of deep-seated mycoses occuring with hématologie neoplasia (1 053 patients). Mycosis 1991 ; 34 (suppl.) : 25-7.
3. Fegeier W. Aspekte zur Diagnostik und Frühdia-gnostik von Organ- und Systemmykosen. In : Heizmann WR, ed. System/sehe Pilzinfektionen. Stuttgart : Wissenschaft-liebe Verlagsgesellschaft mbH, 1993: 15-31.
4. Goodman JL, Winston DJ, Greenfield RA, et al. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engt J Med 1992; 326: 845-51.
5. Maschmeyer G, Link H, Hiddemann W, et al. Empirische antimikrobielle thérapie bei neutropenischen patienten. Ergebnisse einer multizentrischen Studie der arbeitsgruppe Infecktionen in der Haematologie der Paul-Ehrlich-Gesellschaft. Med Klinik 1994 ; 89: 114-23.
6. Roos N, Vassallo P, Fahrenkamp A, et al. Pulmonary aspergillosis and candidiasis : differentiation with CT. Radiology 1990 ; 177 (suppl.) : 359 ff.
7. Viscoli C, Castagnola E, van Lint MT, et al. Fluconazole versus amphotericin B as empirical antifungal therapy of unexplained fever in granubcytopenic cancer patients : a pragmatic, multicentre, prospective and randomized clinical trial. EurJ Cancer 1996 ; 32A : 814-20.
8. De Pauw BE, RaemaekersJMM, DonnellyJP, Kullberg Bj, MeisJFGM. An open study on the safety and efficacy of fluconazole in the treatment of disseminated Candida infections in patients treated for hematological malignancy. Ann Hemalol 1995 ; 70 : 83-7.
9. Anaissie E, Bodey GP, Kanlarjian H, et al. Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy. AmJ Med 1991 ; 91 : 142-50.
10. Kujath P, Lerch K, Kochendörfer P, Boos C. Comparitive study of the efficacy of fluconazole versus amphotericin B/flucytosine in surgical patients with systemic mycoses. Infection 1993; 21 : 376-82.
11. 1. RexJH, BennettJE, Sugar AM, el al. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. N Engl J Med 1994; 331 : 1325-31.