Induction of protective immune responses by immunization with linear multiepitope peptides based on conserved sequences from Plasmodium falciparum antigens

Infection and Immunity

Volumn 66, Issue 7, 1998, Pages 3232-3241

  Bharadwaj, Ashima ^a   Sharma, Pawan ^a   Joshi, Sunil K ^a   Singh, Balwan ^a   Chauhan, V S ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MALARIA VACCINE; PARASITE ANTIBODY; PARASITE ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION PREVENTION; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPOROZOITE;

EID: 0031867249     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.7.3232-3241.1998     Document Type: Article

References (47)

1. Bachmann, M. F., H. Hengartner, and R. M. Zinkernegel. 1995. T helper cell independent neutralising B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction? Eur. J. Immunol. 25:3445-3451.
2. Ballou, W. R., S. L. Hoffman, J. A. Sherwood, M. R. Hollingdale, F. A. Neva, W. T. Hockmeyer, D. M. Gordon, I. Schneider, R. A. Wirtz, J. F. Young, J. F. Waserman, P. Reeve, C. L. Diggs, and J. D. Chulay. 1987. Safety and efficacy of recombinant Plasmodium falciparum sporozoite DNA vaccine. Lancet i:1277-1281.
3. Ballou, W. R., J. Rothbard, R. A. Wirtz, D. M. Gordon, J. S. Williams, R. W. Gore, I. Schneider, M. R. Hollingdale, R. L. Beaudoin, W. L. Maloy, L. H. Miller, and W. T. Hockmeyer. 1985. Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum. Science 228:996-999.
4. Bouharoun-Tayoun, H., P. Altanals, A. Sabchareon, T. Changsuphajaisiddhi, and P. Druilhe. 1990. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth in vitro, but act in cooperation with monocytes. J. Exp. Med. 172:1633-1641.
5. Bouharoun-Tayoun, H. D., and P. Druilhe. 1992. Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect. Immun. 60:1473-1481.
6. Brooks, B. R., R. W. Pastor, and F. W. Carson. 1987. Theoretically determined three dimensional structure for the repeating tetrapeptide unit of the circumsporozoite coat protein of the malaria parasite Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 84:4470-4474.
7. Cerami, C., U. Frevert, P. Sinnis, B. Tackacs, P. Clavejo, M. J. Santos, and V. Nussenzweig. 1992. The basolateral domain of hepatocyte plasma membrane bears the receptor for CSP of Plasmodium falciparum sporozoites. Cell 70:1021-1023.
8. Certa, U., P. Ghersa, H. Dobeli, H. Matile, H. P. Kochar, I. K. Srivastava, A. R. Shaw, and L. H. Perrin. 1988. Aldolase activity of Plasmodium falciparum protein with protective properties. Science 240:1036-1038.
9. Chatterjee, S., M. Wery, P. Sharma, and V. S. Chauhan. 1995. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge. Infect. Immun. 63:4375-4381.
10. Chatterjee, S., P. Sharma, S. Kumar, and V. S. Chauhan. 1994. Fine specificity of immune responses to epitopic sequences in synthetic peptides containing B and T epitopes from conserved P. falciparum blood stage antigens. Vaccine 13:1474-1481.
11. Cohen, S., G. A. Butcher, G. H. Mitchell, J. A. Deans, and J. Langhorn. 1977. Acquired immunity and vaccination in malaria. Am. J. Trop. Med. Hyg. 26:223-227.
12. Cohen, S., I. A. McGregor, and S. C. Carrington. 1961. Gamma globulin and acquired immunity to malaria. Nature (London) 192:733-737.
13. Dame, J. B., J. L. Williams, T. F. McCutchan, J. L. Weber, R. A. Wirtz, W. T. Rockmeyer, W. L. Maloy, J. D. Haynes, I. Schneider, D. Roberts, G. S. Sanders, E. P. Reddy, C. L. Diggs, and L. H. Miller. 1984. Structure of the gene encoding the immunodominant surface antigen in the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593-599.
14. Dolan, S. A., L. H. Miller, and T. E. Wellems. 1990. Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum. J. Clin. Invest. 86:618-624.
15. Francis, M. J., C. M. Fry, D. J. Rowlands, J. L. Bittle, R. A. Houghton, R. A. Lerner, and F. Brown. 1987. Immune response to uncoupled peptides of foot and mouth disease virus. Immunology 61:1-6.
16. Golvano, J., J. L. Lasarte, P. Sarobe, A. Gullan, J. Prieto, and F. B. Cuesta. 1990. Polarity of immunogen: implications for vaccine design. Eur. J. Immunol. 20:2363-2366.
17. Good, M. F., D. Pombo, I. A. Quakyi, E. M. Riley, R. A. Houghton, A. Menon, D. W. Alling, J. A. Berzfosky, and L. H. Miller. 1988. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc. Natl. Acad. Sci. USA 85:1199-1203.
18. Good, M. F., W. L. Moloy, M. N. Lunde, H. Margalit, J. L. Cornetto, G. L. Smith, B. Moss, L. H. Muller, and J. A. Berzofsky. 1987. Construction of a synthetic immunogen: use of a new T-helper epitope on malaria circumsporozoite protein. Science 235:1059-1062.
19. Goundis, D., and B. M. Reid. 1988. Properdin, the terminal complement components, thrombospondin and CSP of malaria parasites contain similar sequence motifs. Nature (London) 335:82-85.
20. Herrington, D. A., D. F. Clyde, G. Losonsky, M. Cortesia, J. R. Murphy, J. Dais, S. Baqar, A. M. Felix, E. P. Heighmer, G. Gillesen, E. Nardin, R. S. Nussenzweig, V. Nussenzweig, M. R. Hollingdale, and M. M. Levine. 1987. Safety and immunogenicity in man of synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature (London) 328:257-259.
21. Hoffman, S. L., and T. R. Jones. 1994. Malaria vaccine development. Clin. Microbiol. Rev. 7:303-310.
22. Howard, R. J., and B. L. Paloske. 1993. Target antigen for asexual malaria vaccine development. Parasitol. Today 9:369-372.
23. Kaslow, D. C., I. A. Quakyi, C. Syin, M. G. Raum, D. B. Keister, J. E. Coligan, T. F. McCutchan, and L. H. Miller. 1988. A vaccine candidate from sexual stage of human malaria that contains EGF like domains. Nature (London) 333:74-76.
24. Kumar, S., L. H. Miller, I. A. Quakyi, D. B. Keister, R. A. Houghten, W. L. Maloy, B. Moss, J. A. Berzfosky, and M. F. Good. 1988. Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum. Nature (London) 334:258-260.
25. Lambrose, C., and J. Vanderberg. 1979. Synchronization of P. falciparum erythrocytic stages in culture. J. Parasitol. 65:418-420.
26. Locksley, R. M., and P. Scott. 1991. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today 12: 58-60.
27. Milich, D. R., A. McLachlan, G. B. Thornton, and J. L. Hughes. 1987. Antibody production to the nucleocapsid and envelope of hepatitis B virus primed by single synthetic T-cell site. Nature (London) 329:547-549.
28. Muller, H. M., I. Reckman, M. R. Hollingdale, H. Bujard, K. J. H. Robson, and A. Crisanti. 1993. Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glyco conjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytcs. EMBO J. 12:2881-2889.
29. Nardin, E. H., and R. S. Nussenzweig. 1993. T-cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development. Annu. Rev. Immunol. 11:687-727.
30. Nussenzweig, R. S., and V. Nussenzweig. 1981. Development of sporozoite vaccines. Philos. Trans. R. Soc. Lond. 307:117-128.
31. Robinson-Taylor, A. W. 1995. Regulation of immunity to malaria: valuable lessons learned from murine model. Parasitol. Today 11:334-341.
32. Robson, K. J. H., J. R. S. Hall, M. W. Jennings, T. J. R. Harris, K. Marsh, C. I. Newbold, W. E. Tate, and D. J. Weatherall. 1988. A highly conserved amino acid sequence in thombospondin, properdin, and sequence from sporozoites and blood stages of human malaria parasites. Nature (London) 335:79-82.
33. Rogers, W. O., M. D. Rogers, R. C. Hedstrom, and S. L. Hoffman. 1992. Characterisation of the gene encoding sporozoite surface protein, a protective Plasmodium yoelii sporozoite antigen. Mol. Biochem. Parasitol. 53:45-52.
34. Rogers, W. O., A. Malik, S. Mellouck, K. Nakamura, M. D. Rogers, A. Szarfman, D. M. Gordon, A. K. Nussler, M. Aikawa, and S. L. Hoffman. 1992. Characterization of Plasmodium falciparum sporozoite surface protein-2. Proc. Natl. Acad. Sci. USA 89:9176-9180.
35. Romero, P. 1992. Malaria vaccines. Curr. Opin. Immunol. 4:432-441.
36. Sakurai, T., A. Ametani, Y. Nakamura, N. Shimizu, T. Idota, and S. Kaminogawa. 1995. Cryptic B cell determinant: in a short peptide T-cells do not induce antibody response of B-cells when their determinants entirely overlap each other. Int. Immunol. 5:793-800.
37. + cytotoxic T-lymphocytes against the Plasmodium falciparum circumsporozoite protein. J. Immunol. 149:966-971.
38. Sejwali, P., et al. Unpublished data.
39. Sharma, P., A. Bharadwaj, V. K. Bhasin, V. N. Sailaja, and V. S. Chauhan. 1996. Antibodies to a conserved-motif peptide sequence of the Plasmodium falciparum thrombospondin-related anonymous protein and circumsporozoite protein recognize a 78-kilodalton protein in the asexual blood stages of the parasite and inhibit merozoite invasion in vitro. Infect. Immun. 64:2172-2179.
40. Sharma, P., A. Kumar, S. Batni, and V. S. Chauhan. 1993. Codominant and reciprocal T-helper cell activity of epitopic sequences and formation of junctional B-cell determinants in synthetic T:B chimeric immunogens. Vaccine 11:1321-1326.
41. Shear, L. H., R. Srinivasan, T. Nolan, and C. Ng. 1989. Role of IFN-γ in lethal and non-lethal malaria in susceptible and resistant murine hosts. J. Immunol. 143:2038-2044.
42. Stoute, J. A., M. Saloui, D. G. Happner, et al. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336:86-91.
43. Trager, W., and J. B. Jensen. 1975. Human malaria parasite in continuous culture. Science 143:673-675.
44. Wang, R., Y. Charoenvit, G. Corradin, R. Porozzi, R. L. Hunter, G. Glenn, C. R. Alving, P. Church, and S. L. Hoffman. 1995. Induction of polyclonal antibodies by immunisation with Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. J. Immunol. 154:2784-2793.
45. White, K., U. Krzych, D. M. Gordon, T. G. Porter, R. L. Richards, C. R. Alving, C. D. Deal, M. Hollingdale, C. Silverman, D. R. Sylvester, W. R. Ballou, and M. Gross. 1993. Induction of cytolytic and antibody response using Plasmodium falciparum repeatless circumsporozoite protein encapsulated in liposomes. Vaccine 11:1341-1346.
46. White, W. I., C. B. Evans, and D. W. Taylor. 1991. Antimalarial antibodies of the immunoglobulin G2a isotype modulate parasitemias in mice infected with Plasmodium yoelii. Infect. Immun. 59:3547-3554.
47. Wrightsman, R. A., B. D. Dawson, D. L. Fouts, and J. E. Manning. 1994. Identification of immunodominant epitopes in Trypanosoma cruzi trypomastigote surface antigen-1 protein that mask protective epitopes. J. Immunol. 153:3148-3154.