The NA'null' phenotype of a young man is caused by an FcγRIIIB gene deficiency while the products of the neighboring FcγRIIA and FcγRIIIA genes are present

Annals of Hematology

Volumn 76, Issue 5, 1998, Pages 215-220

  Flesch, B K ^a   Achtert, G ^a   Bauer, F ^a   Neppert, J ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Fc RIIIb deficiency; NA'null'; NA1 NA2 polymorphism; SH antigen

Indexed keywords

ANTIBODY; CD24 ANTIGEN; CELL SURFACE MARKER; FC RECEPTOR; GENE PRODUCT; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; RECEPTOR SUBTYPE;

ADULT; ALLELE; ARTICLE; B LYMPHOCYTE; CASE REPORT; CHROMOSOME 1Q; CONTROLLED STUDY; GENE DELETION; GENE LOCATION; HOUSE DUST ALLERGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MONOCYTE; NEUTROPHIL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD19; DNA; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; ISOANTIGENS; MALE; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; PHENOTYPE; POLYMERASE CHAIN REACTION; RECEPTORS, IGG;

EID: 0031866112     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050392     Document Type: Article

References (24)

1. Bux J, Stein EL, Santoso S, Mueller-Eckhardt C (1995) NA gene frequencies in the German population, determined by polymerase chain reaction with sequence-specific primers. Transfusion 35:54-57
2. Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S (1997) Characterization of a new alloantigen (SH) on the human neutrophil Fc receptor IIIB. Blood 89:1027-1034
3. Clark MR, Liu L, Clarkson SB, Ory PA, Goldstein IM (1990) An abnormality of the gene that encodes neutrophil Fc receptor III in a patient with systemic lupus erythematosus. J Clin Invest 86:341-346
4. de Haas M, Kleijer M, van Zwieten R, Roos D, von dem Borne AEGKr (1995) Neutrophil FcγRIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families. Blood 86:2403-2413
5. de Haas M, Porcelijn LC, van der Kolk K, Kos M, Overbeeke A, von dem Borne AEGKr (1996) Human anti-5b antisera recognize a glycoprotein migrating from 70 to 95 kD on SDS gels. Transfusion Med 6:180-181
6. de Wit TPM, Suijkerbuijk RF, Capel PJA, van Kessel AG, van de Winkel JGJ (1993) Assignment of three human high-affinity Fe receptor I genes to chromosome 1. band q21.1. Immunogenetics 38:57-59
7. Farace F, Mitjavila MT, Betaieb A, Dokhelar MC, Wiels J, Finale Y, Kieffer N, Breton-Gorius J, Vainchenker W, Tursz T (1988) New hematopoietic differentation antigens detected by anti-K562 monoclonal antibodies. Cancer Res 48:5759-5765
8. Fleit HB, Wright SD, Unkeless JC (1982) Human neutrophil Fc receptor distribution and structure. Proc Natl Acad Sci U S A 79:3275-3279
9. Fleit HB, Kuhnle M, Kobasiuk CD (1989) Monoclonal antibodies to CD16 detect antigenic differences in FcγRIII on neutrophils and natural killer cells. In: Knapp W, Dörken B, Gilks WR, et al (eds) Leucocyte typing IV. Oxford University Press, Oxford, pp 597-581
10. Flesch BK, Bauer F, Neppert J (1998) Rapid typing of the human Fc receptor IIa polymorphism by polymerase chain reaction amplification with allele-specific primers. Transfusion (in press)
11. Fromont P, Bettaieb A, Skouri H, Floch C, Poulet E, Duedari N, Bierling P (1992) Frequency of the polymorphonuclear neutrophil Fc receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia. Blood 79:2131-2134
12. Grage-Griebenow E, Lorenzen D, Fetting R, Flad HD, Ernst M (1993) Phenotypical and functional characterization of Fc receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity. Eur J Immunol 23:3126-3135
13. Huizinga TWJ, Kleijer M, Tetteroo PAT, Roos D, von dem Borne AEGKr (1990) Biallelic neutrophil NA-antigen system is associated with a polymorphism on the phospho-inositol-linked Fc receptor III (CD16). Blood 75:213-217
14. Huizinga TWJ, Kuijpers RWAM, Kleijer M, Schulpen TWJ, Cuypers TM, Roos D, von dem Borne AEGKr (1990) Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. Blood 76:1927-1932
15. Hulett MD, Hogarth PM (1994) Molecular basis of Fc receptor function. Adv Immunol 57:1-127
16. McCullough J, Clay ME, Priest JR, Jensen NJ, Lau S, Noreen HJ, Krivit W, Lalezari P (1981) A comparison of methods for detecting leukocyte antibodies in autoimmune neutropenia. Transfusion 21:483-492
17. Muniz-Diaz E, de Haas M, Madoz P, Koene HR, Kleijer M, Arilla M, Gracia M, Puig LL, von dem Borne AEGKr (1996) High frequency of the neutrophil FcγRIIIb deficiency in Spain. A study of 20 individuals from 4 families. Transfusion Med 6:194
18. Press C, Kline WE, Clay ME, McCullough J (1985) A microtiter modification of granulocyte immunofluorescence. Vox Sang 49:110-113
19. Qiu WQ, De Bruin D, Brownstein BH, Pearse R, Ravetch JV (1990) Organization of the human and mouse low-affinity Fcgamma R genes: duplication and recombination. Science 248:732-735
20. Ravetch JV, Kinet JP (1991) Fc receptors. Annu Rev Immunol 9:457-492
21. Schnackenberg L, Flesch BK, Neppert J (1997) Linkage disequilibria between Duffy blood groups, FcγRIIa and FcγRIIIb allotypes. Exp Clin Immunogenet 14:235-242
22. Selvaraj P, Rosse WF, Silber R, Springer TA (1988) The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria. Nature 333:565-567
23. Stroncek DF, Skubitz KM, Plachta LB, Shankar RA, Clay ME, Herman J, Fleit HB, McCullough J (1991) Alloimmune neonatal neutropenia due to an antibody to the neutrophil Fc receptor III with maternal deficiency of CD16 antigen. Blood 77:1572-1580
24. van de Winkel JGJ, Capel PJA (1996) Yellow pages. In: van de Winkel JGJ, Capel JA (eds) Human IgG Fc receptors. Springer, Berlin Heidelberg New York, pp 227-238