Use of reinduced experimental autoimmune encephalomyelitis to evaluate the importance of epitope spread

International Immunology

Volumn 10, Issue 6, 1998, Pages 743-748

  Lindsey, J William ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Autoimmunity; Epitope; Experimental autoimmune encephalomyelitis; In vivo animal models; Multiple sclerosis; Neuroimmunology

Indexed keywords

ENCEPHALITOGENIC PROTEIN; EPITOPE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; FEMALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; AUTOIMMUNE DISEASES; CELL CULTURE TECHNIQUES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; FEMALE; LYMPH NODES; MICE; MYELIN BASIC PROTEINS; PROTEOLIPIDS; T-LYMPHOCYTES; TIME FACTORS;

EID: 0031865878     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.6.743     Document Type: Article

References (15)

1. McCarron, R. M., Fallis, R. J. and McFarlin, D. E. 1990. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J. Neuroimmunol. 29:73.
2. Perry, L. L., Barzaga-Gilbert, E. and Trotter, J. L. 1991. T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis. J. Neuroimmunol. 33:7.
3. Lehmann, P. V., Forsthuber, T., Miller, A. and Sercarz, E. E. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
4. Cross, A., Tuohy, V. K. and Raine, C. S. 1993. Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell. Immunol. 146:261.
5. McRae, B. L., Vanderlugt, C. L., Dal Canto, M. C. and Miller, S. D. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75.
6. Zhao, M. L. and Fritz, R. B. 1995. The immune response to a subdominant epitope in myelin basic protein exon-2 results in immunity to intra- and intermolecular dominant epitopes. J. Neuroimmunol. 61:179.
7. Jansson, L., Diener, P., Engstroem, A., Olsson, T. and Holmdahl, R. 1995. Spreading of the immune response to different myelin basic protein peptides in chronic experimental autoimmune encephalomyelitis in B1O.RIII mice. Eur. J. Immunol. 25:2195.
8. Yu, M., Johnson, J. M. and Tuohy, V. K. 1996. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J, Exp. Med. 183:1777.
9. Voskuhl, R. R., Farris, R. W., Nagasato, K., MacFarland, H. F. and Dalcq, M. D. 1996. Epitope spreading occurs in active but not passive EAE induced by myelin basic protein. J. Neuroimmunol. 70:103.
10. Genain, C. P., Lee-Parritz, D., Nguyen, M. H., Massacesi, L., Joshi, N., Ferrante, R., Hoffman, K., Moseley, M., Letvin, N. L. and Hauser, S. L. 1994. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 94:1339.
11. Lindsey, J. W., Pappolla, M. and Steinman, L. 1995. Reinduction of experimental autoimmune encephalomyelitis in mice. Cell. Immunol. 162:235.
12. Lindsey, J. W. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44:292.
13. Bourdette, D., Mass, M. and Jones, R. 1996. Adoptively transferred experimental autoimmune encephalomyelitis (EAE) in SCID mice: relapses in EAE may not require 'antigen spread'. Neurology 46 (Suppl.):A285.
14. Ben-Nun, A., Yossefi, S. and Lehmann, D. 1993. Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23:689.
15. Tuohy, V. K., Yu, M., Weinstock-Guttman, B. and Kinkel, R. P. 1997. Diversity and plasticity of self recognition during the development of multiple sclerosis. J. Clin. Invest. 99:1682.