CD8+/CD57+ cells and apoptosis suppress T-cell functions in multiple myeloma

British Journal of Haematology

Volumn 100, Issue 3, 1998, Pages 469-477

  Frassanito, M A ^a,b   Silvestris, F ^a   Cafforio, P ^a   Dammacco, F ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Section of Internal Medicine   (Italy)

Author keywords

Apoptosis; CD8+ CD57+ lymphocytes; Fas; Multiple myeloma

Indexed keywords

CD57 ANTIGEN; CD8 ANTIGEN;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CYTOFLUOROMETRY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; LYMPHOCYTE COUNT; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS TRANSFORMATION;

ANTIGENS, CD57; ANTIGENS, CD8; APOPTOSIS; CD4-CD8 RATIO; CELL DIVISION; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MULTIPLE MYELOMA; T-LYMPHOCYTES;

EID: 0031864805     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00589.x     Document Type: Article

References (42)

1. Alderson, M.R., Armitage, R.J., Maraskovsky, E., Tough, T.W., Roux, E., Schooley, K., Ramsdell, F. & Lynch, D.H. (1993) Fas transduces activation signals in normal human T lymphocytes. Journal of Experimental Medicine, 178, 2231-2235.
2. + lymphocytes from bone marrow transplant patients inhibits cell-mediated cytolysis. Blood, 77, 2237-2241.
3. + lymphocytes in patients with rheumatoid arthritis: correlation with duration of disease. Arthritis and Rheumatism, 36, 608-612.
4. + T lymphocytes are derived from CD57 precursor by differentiation occurring in late immune responses. European Journal of Immunology, 24, 1503-1509.
5. Durie, B.G.M. & Salmon, S.E. (1977) Multiple myeloma, macroglobulinemia and monoclonal gammopathies. Recent Advances in Haematology (ed. by A. V. Hoffbrand, M. C. Brown and J. Hirsch), p. 243. Churchill Livingstone, New York.
6. + T cells with restricted T-cell receptor β chain variability after bone marrow transplantation. Blood, 83, 587-595.
7. + lymphocyte subsets in relation to cytomegalovirus carrier status and its correlate with pokeweed mitogen-induced B cell differentiation. Clinical and Experimental Immunology, 74, 245-251.
8. Green, D.R. & Scott, D.W. (1994) Activation-induced apoptosis in lymphocytes. Current Opinion in Immunology, 6, 476-487.
9. James, S.P., Neckers, L.M., Graeff, A.S., Cossman, J., Blanch, C.M. & Strober, W. (1984) Suppression of immunoglobulin synthesis by lymphocyte subpopulations in patients with Crohn's disease. Gastroenterology, 86, 1510-1518.
10. Joly, P., Guillon, J.M., Mayaud, C., Plata, F., Theodorou, I., Denis, M., Debre, P. & Autran, B. (1989) Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes. Journal of Immunology, 143, 2193-2201.
11. Kawano, M., Iwato, K., Asaoku, H., Tanabe, O., Tanaka, H., Ishikawa, H. & Kuramoto, A. (1989) Altered cytokine activities are related to the suppression of synthesis of normal immunoglobulin in multiple myeloma. American Journal of Hematology, 30, 91-96.
12. Klas, C., Debatin, K.M., Jonker, R.R. & Krammer, P.H. (1993) Activation interferes with the Apo-1 pathway in mature human T cells. International Immunology, 5, 625-630.
13. Lahat, N., Aghai, E. & Froom, P. (1988) T-cells of multiple myeloma patients triggered by the autologous mixed lymphocyte reaction suppress polyclonal immunoglobulin synthesis. Cancer, 62, 1124-1128.
14. MacKenzie, M.R., Paglieroni, T.G. & Warner, N.L. (1987) Multiple myeloma: an immunologic profile. The EA rosette-forming cell is a Leu-1 positive immunoregulatory B cell. Journal of Immunology, 139, 24-28.
15. Massaia, M., Borrione, P., Attisano, C., Barral, P., Beggiato, E., Montacchini, L., Bianchi, A., Boccadoro, M. & Pileri, A. (1995) Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood, 85, 3679-3687.
16. Massaia, M., Dianzani, U., Bianchi, A., Camponi, A., Boccadoro, M. & Pileri, A. (1989) Immune dysregulation in monoclonal gammopathies. Bone Marrow Transplantation, 4, 165-169.
17. Miller, G. & Lipman, M. (1973) Release of infectious Epstein Barr virus by transformed marmoset leukocytes. Proceedings of the National Academy of Sciences of the United States of America, 70, 190-194.
18. + subset. Journal of Immunology, 154, 6182-6190.
19. + T cells in patients with multiple myeloma and paraproteinemia. Blood, 87, 3297-3306.
20. Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. & Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods, 139, 271-275.
21. Omedé, P., Boccadoro, M., Gallone, G., Frieri, R., Battaglio, S., Redoglia, V. & Pileri, A. (1990) Multiple myeloma: increased circulating lymphocytes carrying plasma cell-associated antigens as an indicator of poor survival. Blood, 76, 1375-1381.
22. Ozer, H., Han, T., Henderson, E.S., Nussbaum, A. & Sheedy, D. (1981) Immunoregulatory T cell function in multiple myeloma. Journal of Clinical Investigation, 67, 779-789.
23. Peest, D., Brunkhorst, U., Skedel, I. & Deicher, H. (1984) In vitro immunoglobulin production by peripheral blood mononuclear cells from multiple myeloma patients and patients with benign monoclonal gammopathy: regulation by cell subsets. Scandinavian Journal of Immunology, 19, 149-157.
24. Peest, D., Hölsher, R., Weber, R., Leo, R. & Deicher, H. (1989) Suppression of polyclonal B cell proliferation mediated by supernatants from human myeloma bone marrow cell cultures. Clinical and Experimental Immunology, 75, 252-257.
25. Petersen, J., Drivsholm, A., Brandt, M., Ambjørnsen, A. & Dickmeiss, E. (1989) B lymphocyte function in multiple myeloma: analysis of T cell- and monocyte-dependent antibody production. European Journal of Haematology, 42, 193-201.
26. Pilarski, L.M., Mant, M.J., Ruether, B.A. & Belch, A. (1984) Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients. Journal of Clinical Investigation, 74, 1301-1306.
27. Pilarski, L.M., Mant, M.J., Ruether, B.A., Carayanniotis, G., Otto, D. & Krowka, J.F. (1985a) Abnormal clonogenic potential of T cells from multiple myeloma patients. Blood, 66, 1266-1271.
28. Pilarski, L.M., Ruether, B.A. & Mant, M.J. (1985b) Abnormal function of B lymphocytes from peripheral blood of multiple myeloma. Journal of Clinical Investigation, 75, 2024-2029.
29. + lymphocytes are not likely to be involved in antigen-specific rejection processes in long-term allograft recipients. Clinical and Experimental Immunology, 89, 143-147.
30. + lymphocytes from AIDS patients inhibits T cell cytotoxicity. European Journal of Immunology, 21, 737-741.
31. + T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients. European Journal of Immunology, 24, 2882-2888.
32. + lymphocytes in human immunodeficiency virus infection produce an inhibitor of cytotoxic functions. American Journal of Respiratory and Critical Care Medicine, 149, 972-980.
33. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L.H., Thompson, C.B., Golemis, E., Fong, L., Wang, H.G. & Reed, J.C. (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proceedings of the National Academy of Sciences of the United States of America, 91, 9238-9242.
34. Silvestris, F., Cafforio, P., Frassanito, M.A., Tucci, M., Romito, A., Nagata, S. & Dammacco, F. (1996) Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis. AIDS, 10, 131-141.
35. Sneller, M.C., Strober, W., Eisenstein, E., Jaffe, J.S. & Cunningham-Rundles, C. (1993) New insights into common variable immunodeficiency. Annals of Internal Medicine, 118, 720-730.
36. Takeshita, A. (1986) Regulation of immunoglobulin synthesis by monocytes in multiple myeloma and benign monoclonal gammopathy. Clinical and Experimental Immunology, 67, 625-632.
37. Tienhaara, A. & Pelliniemi, T.T. (1994) Peripheral blood lymphocyte subsets in multiple myeloma and monoclonal gammopathy of undetermined significance. Clinical and Laboratory Haematology, 16, 213-223.
38. Tsujimoto, T., Lisukov, I.A., Huang, N., Mahmoud, M.S. & Kawano, M.M. (1996) Plasma cells induce apoptosis of pre-B cells by interacting with bone marrow stromal cells. Blood, 87, 3375-3382.
39. Ullrich, S. & Zolla-Pazner, S. (1982) Immunoregulatory circuits in myeloma. Clinical Haematology, 11, 87-111.
40. +) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines. European Journal of Immunology, 24, 2903-2909.
41. + cells in normal, healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses. Clinical and Experimental Immunology, 94, 297-305.
42. Wangel, A. (1987) Multiple myeloma and polyclonal hypogammaglobulinaemia. Acta Medica Scandinavica, 221, 421-425.