Investigation of hepatic cytochrome P-450 enzyme induction and DNA adduct formation in male CD/1 mice following oral administration of toxaphene

Journal of Applied Toxicology

Volumn 18, Issue 3, 1998, Pages 173-178

  Hedli, Christine C ^a,c   Snyder, Robert ^a   Kinoshita, Florence K ^b   Steinberg, Marshall ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b Hercules Incorporated   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CYP 2B; CYP 4A1; Cytochrome P 450; DNA adducts; Enzyme induction; Genotoxicity; Liver; Peroxisomal proliferation; Toxaphene

Indexed keywords

CAMPHECLOR; CLOFIBRATE; CYTOCHROME P450; PEROXISOME PROLIFERATOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONCENTRATION (PARAMETERS); DNA ADDUCT; DNA BINDING; ENVIRONMENTAL EXPOSURE; ENZYME ASSAY; ENZYME INDUCTION; IMMUNOBLOTTING; LIVER MICROSOME; LIVER TOXICITY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ISOENZYMES; LIVER; MALE; MICE; MICROBODIES; TOXAPHENE;

ANIMALIA; ZEA MAYS;

EID: 0031864747     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199805/06)18:3<173::AID-JAT488>3.0.CO;2-2     Document Type: Article

References (24)

1. ATSDR, Toxicological Profile for Toxaphene, Agency for Toxic Substances Disease Registry, Division of Toxicology, Atlanta, Georgia (1989)
2. National Cancer Institute, Bioassay of Toxaphene for Possible Carcinogenicity, Carcinogenesis Technical Report Series No. 37, DHEW Publication No 79-837. National Cancer Institute, Bethesda (1979)
3. IARC, Toxaphene (polychlorinated camphenes). In IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol 20: 1-40, pp 327-348 International Agency for Research on Cancer, World Health Organization, Lyon (1979)
4. R. S Waritz, M. Steinberg, F K Kinoshita, C. M Kelly and W R Richter, Thyroid function and thyroid tumors in toxaphene-treated rats. Regul Toxicol Pharmacol 24 184-192 (1996)
5. R. Sharma, B. G Lake, R. Makowski, T. Bradshaw, D. Earnshaw, J. W. Dale and G. G. Gibson, Differential induction of peroxisomal and microsomal fatty acid oxidizing enzymes by peroxisome proliferators in rat liver and kidney Characterization of a renal cytochrome P450 and implications for peroxisome proliferation. Eur. J Biochem. 184, 265 (1989)
6. L M Reik, W Levin, D E Ryan, S. L. Maines and P. E. Thomas, Monoclonal Antibodies distinguish among isozymes of the cytochrome P-450b subfamily. Arch. Biochem. Biophys 242(2), 365-382 (1985)
7. P E Thomas, L M Reik, D E Ryan and W Levin, Induction of two immunochemically related rat liver cytochrome P450 enzymes, cytochrome P450c and cytochrome P450d, by structurally diverse xenobiotics. J Biol Chem. 258, 4590-4598 (1983)
8. T. Omura and R. Sato, The carbon monoxide-binding pigment of liver microsomes I Evidence for its haemoprotein nature. J. Biol. Chem. 239, 2370-2378 (1964).
9. U. K. Laemlli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685 (1970).
10. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7, 1543-1551 (1987).
11. 32P-postlabeling analysis of aromatic carcinogen DNA adducts. Cancer Res. 5, 5656-5662 (1985).
12. 32P-postlabeled DNA-aromatic carcinogen adducts. Anal. Biochem 174, 381-392 (1988).
13. F. K. Kinoshita, J.P. Frawtey, K.P DuBois, Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in the rat. Toxicol. Appl. Pharmacol. 9, 505-513 (1966).
14. I. Chu, D. C. Villeneuve, C. Sun, V. Secours, B. Procter, E. Arnold, D. Clegg, L. Reynolds and V.E. Valli, Toxicity of toxaphene in the rat and beagle dog. Fundam. Appl. Toxicol 7, 406-418 (1986).
15. M. A. Campbell, J. Gyorkos, B. Leece, K. Homonko and S. Safe, The effect of twenty-two organochlorine pesticides as inducers of the hepatic drug metabolizing enzymes. Gen Pharmacol. 14, 445-454 (1983).
16. D. J. Kuntz, G S. Rao, I. E. Berg, R. Khattree and A. K. Chaturvedi, Toxicity of Mixtures of parathion, toxaphene and/or 2,4-D in mice. J. Appl. Toxicol. 10, 257-266 (1990).
17. G. A. Pollock, J. P Krasnec and B. R. Neimann, Rat hepatic microsomal enzyme induction by pretreatment with toxapheno and toxaphene fractions. J Toxicol. Environ Health 11, 355-363 (1983).
18. A. K. Chaturvedi, D. J. Kuntz and G. S Rao, Metabolic aspects of the toxicology of mixtures of parathion, toxaphene and/or 2,4-D in mice. J Appl. Toxicol. 11, 245-251 (1991)
19. I. Chu, V. Secours, DC Villeneuve, V. E. Valli, A. Nakamura, D Colin, D. J. Clegg and E. P Arnold, Reproduction study of toxaphene in the rat. J. Environ. Sci. Health B23, 101-126 (1988).
20. C. C Hedli, N R Rao, K. R. Reuhl, C. M. Witmer and R. Snyder, Effects of benzene metabolite treatment on granulocytic differentiation and DNA adduct formation in HL-60 cells. Arch. Toxicol. 70, 135-144 (1996).
21. C C. Hedli, R. Snyder and C M. Witmer, Bone marrow DNA adducts and bone marrow cellularity following treatment with benzene metabolites in vivo. In Biological Reactive Intermediates IV: Molecular and Cellular Effects and Their Impact on Human Health, ed by C M. Witmer, R. Snyder, D. J. Jollow, G. F Kalf, J J. Kocsis and I. G Sipes, pp. 745-751. Plenum Press, New York (1991).
22. G. G. Gibson, Comparative aspects of the mammalian cytochrome P450IV gene family. Xenobiotica 19, 1123 (1989).
23. R. J. Ruch, R. Fransson, S. Flodstrom, L. Warngard and J. E. Klaunig, Inhibition of hepatocyte gap junctionai intercellular communication by endosulfan, chlordane and heptachlor Carcinogenesis 11, 1097-1101 (1990).
24. G. Williams, An epigenetic mechanism of carcinogenicity of organochlorine pesticides. In Toxicology of halogenated Hydrocarbons: Health and Ecological Effects, ed by M A. Q. Khan and R H. Stanton, pp. 161-242 Pergamon Press New York (1981).