A novel type of structurally simple nonpeptide inhibitors for α- chymotrypsin. Induced-fit binding of methyl 2-allyl-3-benzene-propanoate to the S2 subsite pocket

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 2, 1998, Pages 239-249

  Kim, Dong H ^a   Li, Zhi Hong ^a   Lee, Soo Suk ^a   Park, Jeong Il ^a   Chung, Sang J ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Chymotrypsin; CH interaction; Competitive inhibitors; Induced fit binding; Methyl 2 allyl 3 benzenepropanoate

Indexed keywords

CHYMOTRYPSIN A; CHYMOTRYPSIN INHIBITOR; PROPIONIC ACID DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; HYDROLYSIS; MOLECULAR INTERACTION; RACEMIC MIXTURE;

ALLYL COMPOUNDS; CHYMOTRYPSIN; ENZYME INHIBITORS; MODELS, CHEMICAL; MODELS, MOLECULAR; PHENYLPROPIONATES;

EID: 0031864696     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10038-4     Document Type: Article

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