Arg260-cys mutation in severe factor XIII deficiency: Conformational change of the A subunit is predicted by molecular modelling and mechanics

British Journal of Haematology

Volumn 101, Issue 2, 1998, Pages 264-272

  Ichinose, Akitada ^a   Tsukamoto, Hiroaki ^b   Izumi, Tomonori ^a   Yamazaki, Tomio ^a   Togashi, Masaki ^a   Takamatsu, Junki ^c   Saito, Hidehiko ^d   Umeyama, Hideaki ^b  

^a YAMAGATA UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY HOSPITAL   (Japan)

^d NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bleeding disorder; Factor XIII deficiency; Molecular mechanics; Molecular modelling; Point mutation

Indexed keywords

ARGININE; ASPARTIC ACID; BLOOD CLOTTING FACTOR 13; CYSTEINE; PROTEIN SUBUNIT;

ALLELE; ARTICLE; BLEEDING DISORDER; BLOOD CLOTTING FACTOR 13 DEFICIENCY; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MOLECULAR MODEL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SUBSTITUTION; ARGININE; CYSTEINE; FACTOR XIII DEFICIENCY; FEMALE; HUMANS; MODELS, MOLECULAR; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, RNA;

EID: 0031864267     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00698.x     Document Type: Article

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