Role of tachykinins in the regulation of the hypothalamo-pituitary- adrenal axis

Peptides

Volumn 19, Issue 5, 1998, Pages 949-968

  Nussdorfer, Gastone G ^a,b   Malendowicz, Ludwik K ^c  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Adrenal gland; Hypothalamo pituitary adrenal axis; Neurokinin A; Neurokinin B; Neuropeptide K; Substance P; Tachykinins

Indexed keywords

ALDOSTERONE; NEUROKININ A; NEUROKININ B; NEUROPEPTIDE; NEUROPEPTIDE K; PROTEIN G; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR;

ADRENAL CORTEX; AMINO ACID SEQUENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHROMAFFIN CELL; HYPOPHYSIS ADRENAL SYSTEM; NERVE FIBER; PEPTIDE ANALYSIS; PRIORITY JOURNAL; REVIEW; SECRETORY CELL; STRUCTURE ANALYSIS;

EID: 0031863865     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00017-5     Document Type: Review

References (240)

1. Aguilera, G.; Millan, M. A.; Hauger, R. L.; Catt, K. J. Corticotropin-releasing factor receptors: distribution and regulation in brain, pituitary and peripheral tissues. Ann. N. Y. Acad. Sci. 512:48-66; 1987.
2. Andreis, P. G.; Malendowicz, L. K.; Belloni, A. S.; Nussdorfer, G. G. Effects of pituitary adenylate cyclase-activating peptide (PACAP) on the rat adrenal secretory activity: preliminary in vitro studies. Life Sci. 56:135-142; 1995.
3. Andreis, P. G.; Neri, G.; Belloni, A. S.; Mazzocchi, G.; Nussdorfer, G. G. Interleukin-1 (IL-1)β enhances corticosterone secretion by acting directly on the rat adrenal gland. Endocrinology. 129:53-57; 1991.
4. Andreis, P. G.; Neri, G.; Mazzocchi, G.; Musajo, F. G.; Nussdorfer, G. G. Direct secretagogue effect of corticotropin-releasing factor on the rat adrenal cortex: the involvement of the zona medullaris. Endocrinology. 131:69-72; 1992.
5. Andreis, P. G.; Neri, G.; Nussdorfer, G. G. Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland. Endocrinology. 128:1198-1200; 1991.
6. Andreis, P. G.; Neri, G.; Prayer-Galetti, T.; Rossi, G. P.; Gottardo, G.; Malendowicz, L. K.; Nussdorfer, G. G. Effects of adrenomedullin on the human adrenal gland: an in vitro study. J. Clin. Endocrinol. Metab. 82:1167-1170; 1997.
7. Antoni, F. A. Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr. Rev. 7:351-378; 1986.
8. Antonowicz, U.; Jakubowska-Naziemblo, B.; Cannon, D.; Powell, D. Immunoreactive substance P content in median eminence and pituitary gland during oestrus, dioestrus and after anterior hypothalamic deafferentation. Endokrinologie. 79:25-34; 1981.
9. Arita, J.; Kojima, Y.; Kimura, F. Measurement of the secretion of a small peptide at the single cell level by the cell immunoblot assay: thyroidectomy increases the number of substance P-secreting anterior pituitary cells. Endocrinology. 132:2682-2688; 1993.
10. Aronin, N.; Morency, K.; Leeman, S. E.; Braverman, L. E.; Coslovsky, R. Regulation by thyroid hormone of the concentration of substance P in the rat anterior pituitary. Endocrinology. 114:2138-2142; 1984.
11. Basile, S.; Cheung, N. S.; Livett, B. G. Chromatographic evidence for the presence of multiple tachykinins in the bovine adrenal medulla. J. Neurochem. 58:1584-1586; 1992.
12. 125I]-Bolton-Hunter derivatives of eledoisin and substance P in the rat brain. Neuroscience. 18:857-875; 1986.
13. Bello, A. R.; Marti, E.; Lancha, A.; Beauvillain, J. C.; Tramu, G.; Batista, M. A. P. Presence of substance P and angiotensin II in corticotropic cells of the lizard Gallotia galloti: immunochemical study in the adult and during ontogenesis. Neuroendocrinology. 53:614-622; 1991.
14. 125I]-Bolton-Hunter eledoisin label identical tachykinin binding sites in the rat brain. J. Neurochem. 48:125-133; 1987.
15. Bernet, F.; Bernard, J.; Laborie, C.; Montel, V.; Maubert, E.; Dupouy, J. P. Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerulosa zone could be mediated by catecholamines via β1 adrenergic receptors. Neurosci. Lett. 166:109-112; 1994.
16. Besedovsky, H. O.; Del Rey, A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17:64-102; 1996.
17. Besedovsky, H. O.; Sorkin, E. Network of immune-neuroendocrine interactions. Clin. Exp. Immunol. 27:1-12; 1977.
18. Bittencourt, J. C.; Benoit, R.; Sawchenko, P. E. Distribution and origins of substance P-immunoreactive projections to the paraventricular and supraoptic nuclei: partial overlap with ascending catecholaminergic projections. J. Chem. Neuroanat. 4:63-78; 1991.
19. Bonner, T.; Affolter, H. U.; Young, A. C.; Young, W. S. A cDNA encoding the precursor of the rat neuropeptide neurokinin B. Mol. Brain Res. 2:243-249; 1987.
20. Brown, E. R.; Harlan, R. E.; Krause, J. E. Gonadal steroids regulation of substance P (SP) and SP-encoding messenger ribonucleic acids in the rat anterior pituitary and hypothalamus. Endocrinology. 126:330-340; 1990.
21. Brown, E. R.; Roth, K. A.; Krause, J. E. Sexually dimorphic distribution of substance P in specific anterior pituitary cell populations. Proc. Natl. Acad. Sci. USA. 88:1222-1226; 1991.
22. Brownstein, M. J.; Mroz, E. A.; Kizer, J. S.; Palkovits, M.; Leeman, S. E. Regional distribution of substance P in the brain of the rat. Brain Res. 116:299-305; 1976.
23. Buck, S. H.; Helke, C. J.; Burcher, E.; Shults, C. W.; O'Donohue, T. L. Pharmacological characterization and autoradiographic distribution of binding sites for iodinated tachykinins in the rat central nervous system. Peptides. 7:1109-1120; 1986.
24. Buckingham, J. C.; Smith, T.; Loxley, H. D. The control of ACTH secretion. In: James, V.H.T., ed. The Adrenal Gland. New York: Raven Press; 1992: 131-158.
25. Bucsics, A.; Saria, A.; Lembeck, F. Substance P in the adrenal gland: origin and species distribution. Neuropeptides. 1:329-341; 1981.
26. Burcher, E.; Mussap, C. J.; Geraghty, D. P.; McClure-Sharp, J. M.; Watkins, D. J. Concepts in the characterisation of tachykinin receptors. Ann. N. Y. Acad. Sci. 632:123-136; 1991.
27. Carter, M. S.; Krause, J. E. Structure, expression, and some regulatory mechanism of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide γ. J. Neurosci. 10:2203-2214; 1990.
28. Chang, M. M.; Leeman, S. E. Isolation of sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J. Biol. Chem. 245:4784-4790; 1970.
29. Cheung, C. Y. Adrenal growth and ontogeny of adrenal substance P, enkephalins and catecholamines in the ovine fetus. J. Devel. Physiol. 12:77-84; 1989.
30. Cheung, N. S.; Basile, S.; Livett, B. G. Identification of multiple tachykinins in bovine adrenal medulla using an improved chromatographic procedure. Neuropeptides. 24: 91-97; 1993.
31. Chowdrey, H. S.; Jessop, D.; Lightman, S. Substance P stimulates arginine vasopressin and inhibits adrenocorticotropin release in vivo in the rat. Neuroendocrinology. 52:90-92; 1990.
32. Chowdrey, H. S.; Larsen, P. J.; Harbuz, M. S.; Lightman, S. L.; Jessop, D. S. Endogenous substance P inhibits the depression of corticotropin-releasing hormone during a chronic inflammatory stress. Life Sci. 57:2021-2029; 1995.
33. Clarke, I.; Jessop, D.; Millar, R.; Morris, M.; Bloom, S.; Lightman, S.; Coen, C. W.; Lew, R.; Smith, I. Many peptides that are present in the external zone of the median eminence are not secreted into the hypophysial portal blood of sheep. Neuroendocrinology. 57:765-775; 1993.
34. Coiro, V.; Capretti, L.; Volpi, R.; Davoli, C.; Marcato, A.; Cavazzini, U.; Caffarri, G.; Rossi, G.; Chiodera, P. Stimulation of ACTH/cortisol by i.v. infused substance P in normal men: inhibition by sodium valproate. Neuroendocrinology. 56:459-463; 1992.
35. Coiro, V.; Volpi, R.; Capretti, L.; Gramellini, D.; Cigarini, C.; Papadia, C.; Caiazza, A.; Caffarri, G.; Caffarra, P.; Chiodera, P. Effect of substance P on basal and thyrotropin-releasing hormone-stimulated thyrotropin release in humans. Metabolism. 44:474-477; 1995.
36. Colombo-Benkmann, M.; Heym, C.; Schemann, M. Preganglionic sympathetic neurones, innervating the guinea pig adrenal medulla, immunohistochemically contain choline acetyltransferase and also leu-enkephalin. Neurosci. Lett. 190:155-158; 1995.
37. Colombo-Benkmann, M.; Klimaschewski, L.; Heym, C. Immunohistochemical heterogeneity of nerve cells in the human adrenal gland with special reference to substance P. J. Histochem. Cytochem. 44:369-375; 1996.
38. Coslovsky, R.; Evans, R. W.; Leeman, S. E.; Braverman, L. E.; Aronin, N. The effects of gonadal steroids on the content of substance P in the rat pituitary. Endocrinology. 115:2285-2289; 1984.
39. Coupland, R. E.; Parker, T. L.; Kesse, W. K.; Mohamed, A. A. The innervation of the adrenal gland. III. Vagal innervation. J. Anat. 163:173-181; 1989.
40. Cuello, A. C.; Kanazawa, I. The distribution of substance P immunoreactive fibers in the rat central nervous system. J. Comp. Neurol. 178:129-156; 1978.
41. 3H]senktide. Brain Res. 506:175-179; 1990.
42. Dam, T. V.; Takeda, Y.; Krause, J. E.; Escher, E.; Quirion, R. γ-Preprotachykinin (72-92)-peptide amide. An endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors. Proc. Natl. Acad. Sci. USA. 87:246-250; 1990.
43. Danks, J. A.; Rothman, R. B.; Cashieri, M. A.; Chicchi, G. G.; Liang, T.; Herkenham, M. A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain. Brain Res. 385:273-281; 1986.
44. Dave, J. R.; Eiden, L. E.; Eskay, R. L. Corticotropin-releasing factor binding to peripheral tissue and activation of the adenylate cyclase-adenosine 3′,5′-monophosphate system. Endocrinology. 116:2152-2159; 1985.
45. Debeljuk, L.; Bartke, A. Development of a specific radioimmunoassay for neuropeptide K: its application to Siberian hamster tissues. Peptides. 17:125-129; 1996.
46. Debeljuk, L.; Ghosh, P. K.; Bartke, A. Neurokinin A levels in the hypothalamus of rats and mice: effects of castration, gonadal steroids and expression of heterologous growth hormone genes. Brain Res. Bull. 25:717-721; 1990.
47. Debeljuk, L.; Lam, E. W.; Bartke, A. Effects of castration and sex steroids on neurokinin A concentrations in the anterior pituitary of male rats. Neuroendocrinol. Lett. 13:5-14; 1991.
48. Debeljuk, L.; Rao, J. N.; Bartke, A. Tachykinins and their gene expression in the anterior pituitary of the siberian hamster: effects of photoperiod, thyroid hormones, and analogs of hypothalamic hormones. Endocrine. 3:839-843; 1995.
49. Debeljuk, L.; Villanua, M. A.; Bartke, A. Neurokinin A in the anterior pituitary of female rats: effects of ovariectomy and estradiol. Peptides. 13:1001-1005; 1992.
50. Debeljuk, L.; Villanua, M. A.; Bartke, A. Substance P variations in the hypothalamus of golden hamsters at different stages of the estrous cycle. Neurosci. Lett. 137:178-180; 1992.
51. Debeljuk, L.; Wright, C.; Bartke, A. Transgenic mice overexpressing GH-RH gene have high concentrations of tachykinins in the anterior pituitary gland. In: Rosner, W.; ed. 79th Annual Meeting of the Endocrine Society; Minneapolis 1997. Bethesda: The Endocrine Society Press; Abstract P2·186.
52. De Palatis, L. R.; Fiorindo, R. P.; Ho, R. H. Substance P immunoreactivity in the anterior pituitary gland of the guinea pig. Endocrinology. 110:282-284; 1982.
53. De Palatis, L. R.; Khorram, O.; Ho, R. H.; Negro-Vilar, A.; McCann, S. M. Partial characterization of immunoreactive substance P in the rat pituitary gland. Life Sci. 34:225-238; 1984.
54. Desiderio, D. M.; Kusmierz, J. J.; Zhu, X.; Dass, C.; Hilton, D.; Robertson, J. T.; Sacks, H. S. Mass spectrometric analysis of opioid and tachykinin neuropeptides in nonsecreting and ACTH-secreting human pituitary adenomas. Biol. Mass Spectrom. 22:89-97; 1993.
55. Ding, Y. Q.; Shigemoto, R.; Takada, M.; Ohishi, H.; Nakanishi, S.; Mizuno, N. Localization of the neuromedin K receptor (NK3) in the central nervous system of the rat. J. Comp. Neurol. 364:290-310; 1996.
56. Eckstein, N.; Wehrenberg, W. B.; Louis, K.; Carmel, P. W.; Zimmerman, E. A.; Frantz, E. A.; Ferin, M. Effects of substance P on the anterior pituitary secretion in the female Rhesus monkey. Neuroendocrinology. 31:338-342; 1980.
57. Edwards, A. V.; Jones, C. T. Effects of substance P on adrenal responses to acetylcholine in conscious calves. Am. J. Physiol. 267:E447-E453; 1994.
58. Ehrhart-Bornstein, M.; Bornstein, S. R.; Scherbaum, W. A. Sympathoadrenal system and immune system in the regulation of adrenocortical function. Eur. J. Endocrinol. 135:19-26; 1996.
59. Eskay, R. L.; Eiden, L. E. IL-1α and TNF-α differentially regulate enkephalin, vasoactive intestinal polypeptide, neurotensin, and substance P biosynthesis in chromaffin cells. Endocrinology. 130:2252-2258; 1992.
60. Faria, M.; Navarra, P.; Tsagarakis, S.; Besser, G. M.; Grossman, A. B. Inhibition of CRH-41 release by substance P, but not substance K, from rat hypothalamus in vitro. Brain Res. 538:76-78; 1991.
61. Fischer-Colbrie, R.; Eskay, R. L.; Eiden, L. E.; Maas, D. Transsynaptic regulation of galanin, neurotensin, and substance P in the adrenal medulla: combinatorial control by second-messenger signalling pathways. J. Neurochem. 59: 780-783; 1992.
62. Freidin, M.; Kessler, J. A. Cytokine regulation of substance P expression in sympathetic neurons. Proc. Natl. Acad. Sci. USA. 88:3200-3203; 1991.
63. Gaillard, R. C. Neuroendocrine-immune system interactions. The immune - hypothalamo-pituitary-adrenal axis. Trends Endocrinol. Metab. 5:303-309; 1994.
64. Gallo-Payet, N. Nouveaux concepts sur la régulation de la sécrétion d'aldosterone; interactions endocrines, paracrines, autocrines et neurocrines. Medicine/Science. 9: 943-951; 1993.
65. Ganguly, A.; Davis, J. S. Role of calcium and other mediators in aldosterone secretion from the adrenal glomerulosa cells. Pharmacol. Rev. 46:417-447; 1994.
66. Garland, A. M.; Grady, E. F.; Payan, D. G.; Bunnett, N. W. Mechanisms regulating the responsiveness of cells to substance P: cell-surface degradation of substance P and NK1 receptor endocytosis. Biomed. Res. 15(Suppl. 2):5-13; 1994.
67. Geraghty, D. P.; Livett, B. G.; Rogerson, F. M.; Burcher, E. A novel substance P binding site in bovine adrenal medulla. Neurosci. Lett. 112:276-281; 1990.
68. Gerard, N. P.; Bao, L.; Ping, H. X.; Gerard, C. Molecular aspects of the tachykinin receptors. Regul. Pept. 43:21-35; 1993.
69. Gerard, N. P.; Eddy, R. L.; Shows, T. B.; Gerard, C. The human neurokinin A (substance K) receptor: molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J. Biol. Chem. 265:20455-20462; 1990.
70. Gerard, N. P.; Garraway, L. A.; Eddy, R. L.; Shows, T. B.; Iijima, H.; Paquet, J. L.; Gerard, C. Human substance P receptor (NK1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry. 30:10640-10646; 1991.
71. Gitter, B. D.; Regoli, D.; Howbert, J. J.; Glasebrook, A. L.; Waters, D. C. IL-6 secretion from human astrocytoma cells induced by substance P. J. Neuroimmunol. 51:101-108; 1994.
72. Gitter, B. D.; Waters, D. C.; Threlkeld, P. G.; Lovelace, A. M.; Matsumoto, K.; Bruns, R. F. Cyclosporin A is a substance P (tachykinin NK1) receptor antagonist. Eur. J. Pharmacol. 289:439-446; 1995.
73. Gordon, R. D.; Bachmann, A. W.; Klem, S. A.; Tunny, T. J.; Stowasser, M.; Storie, W. J.; Rutherford, J. G. An association of primary aldosteronism and adrenaline secreting pheochromocytoma. Clin. Exp. Pharmacol. Physiol. 21:219-222; 1994.
74. Grady, E. F.; Garland, A. M.; Gamp, P. D.; Lovett, M.; Payan, D. G.; Bunnett, N. W. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol. Biol. Cell. 6:509-524; 1995.
75. Hanke, W.; Kloas, W. Hormonal regulation of osmomineral content in amphibia. Zool. Sci. 11:5-14; 1994.
76. Harmar, A. J.; Armstrong, A.; Pascall, J. C.; Chapman, K.; Rosie, R.; Curtis, A.; Going, J.; Edwards, C. R. W.; Fink, G. cDNA sequence of human β-preprotachykinin, the common precursor to substance P and neurokinin A. FEBS Lett. 208:67-72; 1986.
77. Hauger, R. L.; Aguilera, G. Regulation of pituitary corticotropin releasing hormone (CRH) receptors by CRH: interaction with vasopressin. Endocrinology. 133:1708-1714; 1993.
78. Hershey, A. D.; Polenzani, L.; Woodward, R. M.; Miledi, R.; Krause, J. E. Molecular and genetic characterization, functional expression, and mRNA expression patterns of a rat substance P receptor. Ann. NY Acad. Sci. 632:63-78; 1991.
79. Heym, C.; Braun, B.; Shuyi, Y.; Klimaschewski, L.; Colombo-Benkmann, M. Immunohistochemical correlation of human adrenal nerve fibers and thoracic dorsal root neurons with special reference to substance P. Histochem. Cell Biol. 104: 233-243; 1995.
80. Hinson, J. P. Paracrine control of adrenocortical function: a new role for the medulla? J. Endocrinol. 124:7-9; 1990.
81. Hinson, J. P.; Cameron, L. A.; Purbrick, A.; Kapas, S. The role of neuropeptides in the regulation of adrenal zona glomerulosa function: effects of substance P, neuropeptide Y, neurotensin, Met-enkephalin, Leu-enkephalin and corticotrophin-releasing hormone on aldosterone secretion in the intact perfused rat adrenal. J. Endocrinol. 140:91-96; 1994.
82. Hinson, J. P.; Cameron, L. A.; Purbrick, A.; Kapas, S. The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leuenkephalin on perfusion medium flow rate in the intact perfused rat adrenal. Regul. Pept. 51:55-61; 1994.
83. Hinson, J. P.; Kapas, S. Effect of splanchnic nerve section and compensatory adrenal hypertrophy on rat adrenal neuropeptide content. Regul. Pept. 61:105-109; 1996.
84. Hinson, J. P.; Kapas, S.; Orford, C. D.; Vinson, G. P. Vasoactive intestinal peptide stimulation of aldosterone secretion by the rat adrenal cortex may be mediated by the local release of catecholamines. J. Endocrinol. 133:253-258; 1992.
85. Hinson, J. P.; Purbrick, A.; Cameron, L. A.; Kapas, S. The role of neuropeptides in the regulation of adrenal zona fasciculata/reticularis function. Effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, Met- and Leuenkephalin and neurotensin on corticosterone secretion in the intact perfused rat adrenal gland in situ. Neuropeptides. 26: 391-397; 1994.
86. Hokfelt, T.; Pernov, B.; Nilsson, G.; Wetterberg, L.; Goldstein, M.; Jeffcoate, S. L. Dense plexus of substance P immunoreactive nerve terminals in eminentia medialis of the primate hypothalamus. Proc. Natl. Acad. Sci. USA. 75:1013-1015; 1978.
87. Holzwarth, M. A. The distribution of vasoactive intestinal peptide in the rat adrenal cortex and medulla. J. Auton. Nerv. Syst. 11:269-283; 1984.
88. Holzwarth, M. A.; Cunningham, L. A.; Kleitman, N. The role of adrenal nerves in the regulation of adrenocortical functions. Ann. N. Y. Acad. Sci. 512:449-464; 1987.
89. Houben, H.; Denef, C. Bioactive peptides in anterior pituitary cells. Peptides. 15:547-582; 1994.
90. Inoue, J.; Oishi, S.; Naomi, S.; Umeda, T.; Sato, T. Pheochromocytoma associated with adrenocortical adenoma: case report and literature review. Endocrinol. Jpn. 33:67-74; 1986.
91. Jessop, D. S.; Chowdrey, H. S.; Biswas, S.; Lightman, S. L. Substance P and substance K in the rat hypothalamus following monosodium glutamate lesions of the arcuate nucleus. Neuropeptides. 18:165-170; 1991.
92. Jessop, D. S.; Chowdrey, H. S.; Larsen, P. J.; Lightman, S. L. Substance P: multifunctional peptide in the hypothalamo-pituitary system? J. Endocrinol. 132:331-337; 1992.
93. Jessop, D. S.; Chowdrey, H. S.; Lightman, S. L. Substance P and substance K in the median eminence and paraventricular nucleus of the rat hypothalamus. Neuropeptides. 17:135-140; 1990.
94. Jonakait, G. M.; Schotland, S.; Hart, R. P. Effects of lymphokines on substance P in injured ganglia of the peripheral nervous system. Ann. N. Y. Acad. Sci. 632:19-30; 1991.
95. Jonassen, J. A.; Mullikin-Kilpatrick, D.; Hoogasian, J.; Benoit, S. E.; Leeman, S. E. Regulation of adenohypophyseal messenger RNAs in female rats by age, hypothyroidism, estradiol and neonatal androgenization. Mol. Cell. Endocrinol. 84:55-64; 1992.
96. Jonassen, J. A.; Mullikin-Kilpatrick, D.; McAdam, A.; Leeman, S. E. Thyroid hormone status regulates preprotachykinin-A gene expression in male rat anterior pituitary. Endocrinology. 121:1555-1561; 1987.
97. Jones, M. T.; Gillham, B.; Holmes, M. C.; Hodges, J. R.; Buckingham, J. C. Influence of substance P on the hypothalamo-pituitary-adrenocortical activity in the rat. J. Endocrinol. 76:183-184; 1978.
98. Jones, P. M.; Ghatei, M. A.; Steel, J.; O'Halloran, D.; Gon, G.; Legon, S.; Burrin, J. M.; Leonhardt, U.; Polak, J. M.; Bloom, S. R. Evidence for neuropeptide Y synthesis in the rat anterior pituitary and the influence of thyroid hormone status: comparison with vasoactive intestinal peptide, substance P, and neurotensin. Endocrinology. 125:334-341; 1989.
99. Ju, G.; Liu, S. J. Substance P-immunoreactive nerve fibers in the pars distalis of the anterior pituitary of macaques. J. Chem. Neuroanat. 2:349-360; 1989.
100. Ju, G.; Liu, S. J. The relationship of substance P-immunoreactive nerve fibers to thyreotropes and corticotropes in the pars distalis of the anterior pituitary of the monkey. Neuroscience. 32:441-450; 1989.
101. Ju, G.; Liu, S. J.; Zhang, X. Peptidergic innervation of the pars distalis of the adenohypophysis. Neuroendocrinology. 53(Suppl. 1):41-44; 1991.
102. Ju, G.; Zhang, X. An electron microscopic study on substance P-like immunoreactive nerve fibers in the pars distalis of the adenohypophysis in the dog. Neuroscience. 38:503-513; 1990.
103. Kako, K.; Munekata, E.; Hosaka, M.; Murakami, K.; Nakayama, K. Cloning and sequence analysis of mouse cDNAs encoding preprotachykinin A and B. Biomed. Res. 14:253-259; 1993.
104. Kalra, P. S.; Dube, M. G.; Kalra, S. P. The effects of IL-1β on the hypothalamic tachykinin, neurokinin A. Brain Res. 662:178-184; 1994.
105. Kalra, P. S.; Kalra, S. P. Neuropeptide K stimulates corticosterone release in the rat. Brain Res. 610:330-333; 1993.
106. Kanazawa, I.; Jessell, T. Post-mortem changes and regional distribution of substance P in the rat and mouse nervous system. Brain Res. 117:362-367; 1976.
107. Kanazawa, I.; Ogawa, T.; Kimura, S.; Munekata, E. Regional distribution of substance P, neurokinin A and neurokinin B in rat central nervous system. Neurosci. Res. 2:111-120; 1984.
108. Kerdelhue, B.; Tartar, A.; Lenior, V.; El-Abed, A.; Hublau, P.; Millar, R. P. Binding studies of substance P anterior pituitary binding sites: changes in substance P binding sites during the rat estrous cycle. Regul. Pept. 10:133-143; 1985.
109. Kesse, W. K.; Parker, T. L.; Coupland, R. E. The innervation of the adrenal gland. I. The source of pre- and postganglionic nerve fibers to the adrenal gland. J. Anat. 157:33-41; 1988.
110. Khalil, Z.; Marley, P. D.; Livett, B. G. Mammalian tachykinins modulate the nicotinic secretory response of cultured bovine adrenal chromaffin cells. Brain Res. 459:289-297; 1988.
111. Khawaja, A. M.; Rogers, D. F. Tachykinins. Receptor to effector. Int. J. Biochem. Cell Biol. 28:721-738; 1996.
112. Kodjo, M. K.; Leboulenger, F.; Conlon, J. M.; Vaudry, H. Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells. Endocrinology. 136: 4535-4542; 1995.
113. Kodjo, M. K.; Leboulenger, F.; Morra, M.; Conlon, J. M.; Vaudry, H. Pharmacological profile of the tachykinin receptor involved in the stimulation of corticosteroid secretion in the frog Rana ridibunda. J. Steroid Biochem. Mol. Biol. 57:329-335; 1996.
114. Kodjo, M. K.; Leboulenger, F.; Porcedda, P.; Lamacz, M.; Conlon, J. M.; Pelletier, G.; Vaudry, H. Evidence for the involvement of chromaffin cells in the stimulatory effect of tachykinins on corticosteroid secretion by the frog adrenal gland. Endocrinology. 136:3253-3259; 1995.
115. Kondo, H. Immunohistochemical analysis of the localization of neuropeptides in the adrenal gland. Arch. Histol. Jpn. 48:453-481; 1985.
116. Kotani, H.; Hoshimaru, M.; Nawa, H.; Nakanishi, S. Structure and gene organization of bovine neuromedin K precursor. Proc. Natl. Acad. Sci. USA. 83:7074-7078; 1986.
117. Kris, R. M.; South, V.; Salzman, A.; Felder, S.; Ricca, G. A.; Jaye, M.; Huebner, K.; Kagan, J.; Croce, C. M.; Schlessinger, J. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. Cell Growth Differ. 2:15-22; 1991.
118. Kuramoto, H.; Kondo, H.; Fujita, T. Substance P-like immunoreactivity in adrenal chromaffin cells and intra-adrenal nerve fibers of rats. Histochemistry. 82:507-512; 1985.
119. Larsen, P. J. Distribution of substance P-immunoreactive elements in the preoptic area and the hypothalamus of the rat. J. Comp. Neurol. 316:287-313; 1992.
120. Larsen, P. J.; Jessop, D. S.; Lightman, S. L.; Chowdrey, H. S. Preprotachykinin A gene expression in distinct hypothalamic and brain stem regions of the rat is affected by a chronic osmotic stimulus: a combined immunohistochemical and in situ hybridization histochemistry study. Brain Res. Bull. 30: 535-545; 1993.
121. Larsen, P. J.; Jessop, D. S.; Patel, H.; Lightman, S. L.; Chowdrey, H. S. Substance P inhibits the release of anterior pituitary adrenocorticotropin via a central mechanism involving corticotrophin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus. J. Neuroendocrinol. 5:99-105; 1993.
122. Larsen, P. J.; Mikkelsen, J. D.; Mau, S.; Saermark, T. Binding and internalization of a iodinated substance P analog by cultured anterior pituitary cells. Mol. Cell. Endocrinol. 65: 91-101; 1989.
123. Larsen, P. J.; Mikkelsen, J. D.; Saermark, T. Binding of a iodinated substance P analog to a NK-1 receptor on isolated cell membranes from rat anterior pituitary. Endocrinology. 124:2548-2557; 1989.
124. Leboulenger, F.; Vaglini, L.; Conlon, J. M.; Homo-Delarche, F.; Wang, Y.; Kerdelhue, B.; Pelletier, G.; Vaudry, H. Immunohistochemical distribution, biochemical characterization and biologic action of tachykinins in the frog adrenal gland. Endocrinology. 133:1999-2008; 1993.
125. Leeman, S. E.; Aronin, N.; Ferris, C. Substance P and neurotensin. Recent Prog. Horm. Res. 38:93-132; 1982.
126. Lesouhaitier, O.; Esneu, M.; Kodjo, M. K.; Hamel, C.; Contesse, V.; Yon, L.; Remy-Jouet, I.; Fasolo, A.; Fournier, A.; Vandesande, F.; Pelletier, G.; Conlon, J. M.; Roubos, E. W.; Feuilloley, M.; Delarue, C.; Leboulenger, F.; Vaudry, H. Neuroendocrine communication in the frog adrenal gland. Zool. Sci. 12:255-264; 1995.
127. Lim, A.; Sherward, J.; Copolov, D.; Windmill, D.; Fink, G. Atrial natriuretic factor is released into hypophysial portal blood: evidence that natriuretic factor may be a neurohormone involved in hypothalamic pituitary control. J. Neuroendocrinol. 2:15-18; 1990.
128. 5]-enkephalin-, vasoactive intestinal polypeptide and substance P-like immunoreactivities in human adrenal glands. Neuroscience. 5:2247-2259; 1980.
129. Liu, Y. Y.; Morris, J. F.; Ju, G. Synaptic relationship of substance P-like-immunoreactive nerve fibers with gland cells of the anterior pituitary in the rat. Cell Tissue Res. 285:227-234; 1996.
130. Ljungdahl, A.; Hokfelt, T.; Nilsson, G. Distribution of substance P-like immunoreactivity in the central nervous system of the rat. I. Cell bodies and nerve terminals. Neuroscience. 3:861-880; 1978.
131. Ljungdahl, A.; Hokfelt, T.; Nilsson, G.; Goldstein, M. Distribution of substance P-like immunoreactivity in the central nervous system of the rat. II. Light microscopic localization in relation to catecholamine-containing neurons. Neuroscience. 3:945-976; 1978.
132. Lowe, J. A. III. Nonpeptide tachykinin antagonists: medicinal chemistry and molecular biology. Med. Res. Rev. 16: 527-545; 1996.
133. MacDonald, M. R.; Takeda, J.; Rice, C. M.; Krause, J. E. Multiple tachykinins are produced and secreted upon posttranslational processing of the three substance P precursors proteins, α-, β-, and γ-preprotachykinin. Expression of the preprotachykinins in AtT-20 cells infected with vaccinia virus recombinants. J. Biol. Chem. 264:15578-15592; 1989.
134. Maeno, H.; Kiyama, H.; Tohyama, M. Distribution of the substance P receptor (NK-1) in the central nervous system. Mol. Brain Res. 18:43-58; 1993.
135. Maggi, C. A. The mammalian tachykinin receptors. Gen. Pharmacol. 26:911-944; 1995.
136. Maggi, C. A.; Patacchini, R.; Rovero, P.; Giachetti, A. Tachykinin receptors and tachykinin receptor antagonists. J. Auton. Pharmacol. 13:23-93; 1993.
137. Maggio, J. E. Tachykinins. Annu. Rev. Neurosci. 11:13-28; 1988.
138. Mai, J. K.; Stephens, P. H.; Hope, A.; Cuello, A. C. Substance P in the human brain. Neuroscience. 17:709-739; 1986.
139. Malendowicz, L. K. Involvement of neuropeptides in the regulation of growth, structure and function of the adrenal cortex. Histol. Histopathol. 8:173-186; 1993.
140. Malendowicz, L. K.; Andreis, P. G.; Markowska, A.; Nowak, M.; Warchol, J. B.; Neri, G.; Nussdorfer, G. G. Effects of neuromedin U-8 on the secretory activity of the rat adrenal cortex: evidence for an indirect action requiring the presence of the zona medullaris. Res. Exp. Med. 194:69-79; 1994.
141. Malendowicz, L. K.; Andreis, P. G.; Nussdorfer, G. G.; Markowska, A. The possible role of endogenous substance P in the modulation of the response of rat pituitary-adrenal axis to stresses. Endocr. Res. 22:311-318; 1996.
142. Malendowicz, L. K.; Markowska, A. Neuromedins and their involvement in the regulation of growth, structure and function of the adrenal cortex. Histol. Histopathol. 9:591-601; 1994.
143. Malendowicz, L. K.; Neri, G.; Nussdorfer, G. G.; Nowak, M.; Filipiak, K.; Warchol, J. B. Effects of substance P and its antagonist spantide on corticosterone secretion and cytosolic free calcium concentration of dispersed zona fasciculatareticularis cells of the rat adrenal cortex. Endocr. Res. 22: 175-184; 1996.
144. Malendowicz, L. K.; Nussdorfer, G. G.; Warchol, J. B.; Markowska, A.; Macchi, C.; Nowak, K. W.; Butowska, W. Effects of neuromedin-K on the rat hypothalamo-pituitary-adrenal axis. Neuropeptides. 29:337-341; 1995.
145. Malendowicz, L. K.; Rebuffat, P.; Nussdorfer, G. G. Stimulatory effect of the substance P antagonist spantide-II on aldosterone secretion of dispersed rat zona glomerulosa cells. Endocr. Res., 23:131-139; 1997.
146. Malendowicz, L. K.; Warchol, J. B.; Nussdorfer, G. G.; Nowak, M.; Filipiak, K. Effects of neurokinin-A on the rat hypothalamo-pituitary-adrenal axis. Endocr. Res. 21:757-767; 1995.
147. Mantyh, P. W.; Gates, T.; Mantyh, C. R.; Maggio, J. E. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J. Neurosci. 9:258-279; 1989.
148. Marksteiner, J.; Sperk, G.; Krause, J. E. Distribution of neurons expressing neurokinin B in the rat brain: immunocytochemical and in situ hybridization. J. Comp. Neurol. 317:341-356; 1992.
149. Massi, M.; Saija, A.; Polidori, C.; Perfumi, M.; Gentili, L.; Costa, G.; De Caro, G. The hypothalamic paraventricular nucleus is a site of action for the central effect of tachykinins on plasma vasopressin. Brain Res. Bull. 26:149-154; 1991.
150. Mau, S. E.; Saermark, T. Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism. J. Endocrinol. 130:63-70; 1991.
151. Mazzocchi, G.; Macchi, C.; Malendowicz, L. K.; Nussdorfer, G. G. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 29:53-58; 1995.
152. Mazzocchi, G.; Malendowicz, L. K.; Andreis, P. G.; Meneghelli, V.; Markowska, A.; Belloni, A. S.; Nussdorfer, G. G. Neuropeptide K enhances glucocorticoid release by acting directly on the rat adrenal gland: the possible involvement of zona medullaris. Brain Res. 661:91-96; 1994.
153. Mazzocchi, G.; Malendowicz, L. K.; Belloni, A. S.; Nussdorfer, G. G. Adrenal medulla is involved in the aldosterone secretagogue effect of substance P. Peptides. 16:351-355; 1995.
154. Mazzocchi, G.; Malendowicz, L. K.; Gottardo, G.; Nussdorfer G. G. Neuropeptide K and neurokinin A stimulate CRH and ACTH release by rat adrenal medulla in vitro. Peptides. 18:487-490, 1997.
155. Mazzocchi, G.; Malendowicz, L. K.; Macchi, C.; Gottardo, G.; Nussdorfer, G. G. Further investigations on the effects of neuropeptide-Y (NPY) on the secretion and growth of rat adrenal zona glomerulosa. Neuropeptides. 30:19-27; 1996.
156. Mazzocchi, G.; Malendowicz, L. K.; Markowska, A.; Nussdorfer, G. G. Effect of hypophysectomy on corticotropin-releasing hormone and adrenocorticotropin immunoreactivities in the rat adrenal gland. Mol. Cell. Neurosci. 5:345-349; 1994.
157. Mazzocchi, G.; Malendowicz, L. K.; Meneghelli, V.; Gottardo, G.; Nussdorfer, G. G. Vasoactive intestinal polypeptide (VIP) stimulates hormonal secretion of the rat adrenal cortex in vitro: evidence that adrenal chromaffin cells are involved in the mediation of the mineralocorticoid, but not glucocorticoid secretagogue action of VIP. Biomed. Res. 14:435-440; 1993.
158. Mazzocchi, G.; Malendowicz, L. K.; Meneghelli, V.; Gottardo, G.; Nussdorfer, G. G. In vitro and in vivo studies of the effects of arginine-vasopressin on the secretion and growth of rat adrenal cortex. Histol. Histopathol. 10:359-370; 1995.
159. Mazzocchi, G.; Malendowicz, L. K.; Rebuffat, P.; Gottardo, G.; Nussdorfer, G. G. Neurotensin stimulates CRH and ACTH release by rat adrenal medulla in vitro. Neuropeptides. 31:8-11; 1997.
160. Mazzocchi, G.; Malendowicz, L. K.; Rebuffat, P.; Tortorella, C.; Nussdorfer, G. G. Arginine-vasopressin stimulates CRH and ACTH release by rat adrenal medulla, acting via the V1 receptor subtype and a protein kinase C-dependent pathway. Peptides. 18:191-195; 1997.
161. Mazzocchi, G.; Musajo, F. G.; Malendowicz, L. K.; Andreis, P. G.; Nussdorfer, G. G. IL-1β stimulates corticotropin-releasing hormone (CRH) and adrenocorticotropin (ACTH) release by rat adrenal gland in vitro. Mol. Cell. Neurosci. 4:267-270; 1993.
162. Mazzocchi, G.; Musajo, F. G.; Neri, G.; Gottardo, G.; Nussdorfer, G. G. Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ: comparison with calcitonin gene-related peptide effects. Peptides. 17: 853-857; 1996.
163. Merchenthaler, I.; Maderdrut, J. L.; O'Harte, F.; Conlon, J. M. Localization of neurokinin B in the central nervous system of the rat. Peptides. 13:815-829; 1992.
164. Mikhail, Y.; Amin, F. Intrinsic innervation of the human adrenal gland. Acta Anat. 72:25-32; 1969.
165. Mikkelsen, J. D.; Larsen, P. J.; Moller, M.; Vilhardt, H.; Saermark, T. Substance P in the median eminence and pituitary of the rat: demonstration of immunoreactive fibers and specific binding sites. Neuroendocrinology. 50:100-108; 1989.
166. Minamino, N.; Matsuda, H.; Kangawa, K.; Matsuo, H. Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord. Biochem. Biophys. Res. Commun. 124:731-738; 1984.
167. Minenko, A.; Oehme, P. Substance P action on inositol phospholipids in rat adrenal medulla slices. Biomed. Biochim. Acta. 46:461-467; 1987.
168. Moons, L.; Cambre, M.; Marivoet, S.; Batten, T. F. C.; Vanderhaeghen, J. J.; Ollevier, F.; Vandesande, F. Peptidergic innervation of the adrenocorticotropic hormone (ACTH)-and growth hormone (GH)-producing cells in the pars distalis of the sea bass (Dicentrarchus labrax). Gen. Comp. Endocrinol. 72:171-180; 1988.
169. Morel, G.; Chayvialle, J. A.; Kerdelhue, B.; Dubois, P. M. Ultrastructural evidence for endogenous substance P-like immunoreactivity in the rat pituitary gland. Neuroendocrinology. 35:86-92; 1982.
170. Mori, M.; Tsushima, H.; Matsuda, T. Substance P injected into the hypothalamic supraoptic nucleus causes antidiuresis through the release of arginine-vasopressin in water-loaded and ethanol-anesthetized rats. Jpn. J. Pharmacol. 62:49-56; 1993.
171. Mori, M.; Yokota, Y.; Yasue, M.; Serikawa, T.; Yamada, J. Assignment of the rat genes coding for substance P receptor, substance K receptor, and neuromedin K receptor to chromosomes 4, 20, and 2, respectively. Cytogenet. Cell Genet. 60:222-223; 1992.
172. Nakanishi, S. Substance P precursor and kininogen: their structures, gene organizations, and regulations. Physiol. Rev. 67:1117-1142; 1987.
173. Nawa, T.; Hirose, T.; Takashima, H.; Inayama, S.; Nakanishi, S. Nucleotide sequences of cloned cDNAs for two types of bovine brain SP precursor. Nature (London). 306:32-36; 1983.
174. Nawa, T.; Kotani, H.; Nakanishi, S. Tissue specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. Nature (London). 312:729-734; 1984.
175. Neri, G.; Andreis, P. G.; Nussdorfer, G. G. Effects of neuropeptide-Y and substance-P on the secretory activity of dispersed zona-glomerulosa cells of rat adrenal gland. Neuropeptides. 17:121-125; 1990.
176. Neri, G.; Andreis, P. G.; Prayer-Galetti, T.; Rossi, G. P.; Malendowicz, L. K.; Nussdorfer, G. G. Pituitary adenylate-cyclase activating peptide (PACAP) enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism probably involving the local release of catecholamines. J. Clin. Endocrinol. Metab. 81:169-173; 1996.
177. Nicholson, S. A.; Adrian, T. E.; Gillham, B.; Jones, M. T.; Bloom, S. R. Effect of hypothalamic neuropeptides on corticotropin release from quarters of rat anterior pituitary gland in vivo. J. Endocrinol. 100:219-226; 1984.
178. Nicoll, R. A. Substance P as a transmitter candidate. Annu. Rev. Neurosci. 5:227-268; 1980.
179. Nilsson, G.; Brodin, E. Tissue distribution of substance P-like immunoreactivity in dog, cat, rat and mouse. In: Von Euler, U.S.; Pernow, B.; eds. Substance P. New York: Raven Press; 1977:49-54.
180. Nussdorfer, G. G. Cytophysiology of the adrenal cortex. Int. Rev. Cytol. 98:1-405; 1986.
181. Nussdorfer, G. G. Paracrine control of adrenal cortical function by medullary chromaffin cells. Pharmacol. Rev. 48:495-530; 1996.
182. Nussdorfer, G. G.; Malendowicz, L. K.; Belloni, A. S.; Mazzocchi, G.; Rebuffat, P. Effects of substance P on the rat adrenal zona glomerulosa in vivo. Peptides. 9:1145-1149; 1988.
183. Nussdorfer, G. G.; Rossi, G. P.; Belloni, A. S. The role of endothelins in the paracrine control of the secretion and growth of the adrenal cortex. Int. Rev. Cytol. 171:267-308; 1997.
184. Nussdorfer, G. G.; Rossi, G. P.; Mazzocchi, G. Role of adrenomedullin and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis. Peptides. 18:1079-1089; 1997.
185. Oomori, Y.; Okuno, S.; Fujisawa, H.; Ishikawa, K.; Satoh, Y.; Matsuda, M.; Yamano, M.; Ono, K. Tyrosine-hydroxylase-immunoreactive nerve fibers in the separated capsule of the rat adrenal gland. Acta Anat. 136:49-54; 1989.
186. Oomori, Y.; Okuno, S.; Fujisawa, H.; Ono, K. Immunoelectron microscopic study of tyrosine hydroxylase immunoreactive nerve fibers and ganglion cells in the rat adrenal gland. Anat. Rec. 229:407-414; 1991.
187. Otsuka, M.; Yoshioka, K. Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73:229-308; 1993.
188. Palkovits, M.; Kakucska, I.; Makara, G. B. Substance P-like immunoreactive fibers in the arcuate nucleus project to the median eminence in rat. Brain Res. 486:364-368; 1989.
189. Panula, P.; Yang, H. Y. T.; Costa, E. Comparative distribution of bombesin/GRP- and substance-P-like immunoreactivities in rat hypothalamus. J. Comp. Neurol. 224:606-617; 1984.
190. Parker, T. L.; Kesse, W. K.; Mohamed, A. A.; Afework, M. The innervation of the mammalian adrenal gland. J. Anat. 183:265-276; 1993.
191. Pattachini, R.; Maggi, C. A. Tachykinin receptors and receptor subtypes. Arch. Int. Pharmacodyn. Ther. 329:161-184; 1995.
192. Pfister, C.; Goerne, R. C. Substance P-like immunofluorescence in the adrenal medulla of the rat. Acta Histochem. 72:127-129; 1983.
193. Poosch, M. S.; Goebel, D. J.; Bannon, M. J. Distribution of neurokinin receptor gene expression in the rat brain. Soc. Neurosci. Abstr. 17:806; 1991.
194. Regoli, D.; Boudon, A.; Fauchere, J. L. Receptors and antagonists for substance P and related peptides. Pharmacol. Rev. 46:551-599; 1994.
195. Reinecke, M.; Heym, C.; Forssmann, W. G. Distribution patterns and coexistence of neurohormonal peptides (ANP, BNP, NPY, SP, CGRP, enkephalins) in chromaffin cells and nerve fibers of the anuran adrenal organ. Cell Tissue Res. 268:247-256; 1992.
196. Rittenhouse, P. A.; Markle, R. A.; Marchand, J. E.; Kream, R. M.; Leeman, S. E. Streptozotocin-induced diabetes produces a decrease in pituitary substance P content and preprotachykinin mRNA. Neurosci. Lett. 211:77-80; 1996.
197. Ronnekleiv, O. K.; Kelly, M. J.; Eskay, R. L. Distribution of immunoreactive substance P neurons in the hypothalamus and pituitary of the Rhesus monkey. J. Comp. Neurol. 224: 51-59; 1984.
198. Roth, K. A.; Krause, J. E. Substance-P is present in a subset of thyrotrophs in the human pituitary. J. Clin. Endocrinol. Metab. 71:1089-1095; 1990.
199. Saffroy, M.; Beaujouan, J. C.; Torrens, Y.; Besseyre, J.; Bergstrom L.; Glowinski, J. Localization of tachykinin binding sites (NK1, NK2, NK3 ligands) in the rat brain. Peptides. 9: 227-241; 1988.
200. Saria, A.; Wilson, S. P.; Molnar, A.; Viveros, O. H.; Lembeck, F. Substance P and opiate-like peptides in human adrenal medulla. Neurosci. Lett. 20:195-200; 1980.
201. Sawchenko, P. E.; Swanson, L. W.; Vale, W. Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat. Proc. Natl. Acad. Sci. USA. 81:1883-1887; 1984.
202. Shadiack, A. M.; Hart, R. P.; Carlson, C. D.; Jonakait, G. M. IL-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitor factor (LIF). J. Neurosci. 13:2601-2609; 1993.
203. Shioda, T.; Nishida, S. The innervation of the adrenal cortex. Arch. Histol. Jpn. 28:23-43; 1967.
204. Shughrue, P. J.; Lane, M. V.; Merchenthaler, I. In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system. J. Comp. Neurol. 372:395-414; 1996.
205. Shults, C. W.; Yajima, H.; Gullner, H. G.; Chase, T. N.; O'Donohue, T. L. Demonstration and distribution of kassinin-like material (substance K) in the rat central nervous system. J. Neurochem. 45:552-558; 1985.
206. 2+ channels. Eur. J. Pharmacol. 219:491-492; 1992.
207. Spangelo, B. L.; Gorospe, W. C. Role of cytokines in the neuroendocrine-immune system axis. Front. Neuroendocrinol. 16:1-22; 1995.
208. Stoeckel, M. E.; Porte, A.; Klein, M. J.; Cuello, A. C. Immunocytochemical localization of substance P in the neurohypophysis and hypothalamus of the mouse compared with the distribution of other neuropeptides. Cell Tissue Res. 223:533-544; 1982.
209. 3H] senktide. Brain Res. 534:1-7; 1990.
210. Tan, G. H.; Carney, J. A.; Grant, C. S.; Young, W. F. Jr. Coexistence of bilateral pheochromocytoma and idiopathic hyperaldosteronism. Clin. Endocrinol. 44:603-609; 1996.
211. Tateishi, K.; Kishimoto, S.; Kobayashi, H.; Kobuke, K.; Matsuoka, Y. Distribution and localization of neurokinin A-like immunoreactivity and neurokinin B-like immunoreactivity in rat peripheral tissue. Regul. Pept. 30:193-200; 1990.
212. Tateishi, K.; Matsuoka, Y.; Hamaoka, T. Establishment of highly specific radioimmunoassays for neurokinin A and neurokinin B and determination of tissue distribution of these peptides in rat central nervous system. Regul. Pept. 24:245-257; 1989.
213. Togashi, H.; Yoshioka, M.; Minami, M.; Shimamura, K.; Saito, H.; Kitada, C.; Fujino, M. Effect of the substance P antagonist spantide on adrenal sympathetic nerve activity in rats. Jpn. J. Pharmacol. 43:253-261; 1987.
214. Tomlison, K. C.; Gardiner, S. M.; Hebden, R. A.; Bennet, T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol. Rev. 44:103-150; 1992.
215. Torpy, D. J.; Grice, J. E.; Hocking, G. I.; Walters, M. M.; Crosbie, G. V.; Jackson, R. V. Alprazolam attenuates vasopressin-stimulated adrenocorticotropin and cortisol release: evidence for synergy between vasopressin and corticotropin-releasing hormone in humans. J. Clin. Endocrinol. Metab. 79:140-144; 1994.
216. Toth, I. E.; Hinson, J. P. Neuropeptides in the adrenal glands: distribution, localization of receptors, and effects on steroid hormone synthesis. Endocr. Res. 21:39-51; 1995.
217. Tramu, G.; Croix, C.; Pillez, A. Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Neuroendocrinology. 37:467-469; 1983.
218. Tsuchida, K.; Shigemoto, R.; Yokota, Y.; Nakanishi, S. Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors. Eur. J. Biochem. 193:751-757; 1990.
219. Tsuro, Y.; Kawano, H.; Nishiyama, T.; Hisano, S.; Daikoku, S. Substance P-like immunoreactive neurons in the tuberoinfundibular area of rat hypothalamus. Light and electron microscopy. Brain Res. 289:1-9; 1983.
220. Udelsman, R.; Harwood, J. P.; Millan, M. A.; Chrousos, G. P.; Goldstein, D. S.; Zimlichman, R.; Catt, K. J.; Aguilera, G. Functional corticotropin-releasing factor receptors in the primate peripheral sympathetic nervous system. Nature (London). 319:147-150; 1986.
221. Unsicker, K.; Habura-Flueh, O.; Zwarg, U. Different types of small granule-containing cells and neurons in the guinea pig adrenal medulla. Cell Tissue Res. 189:109-130; 1978.
222. Vale, W.; Spiess, J.; Rivier, C.; Rivier, J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science (Washington DC). 233:1394-1397; 1981.
223. Vaupel, R.; Jarry, H.; Schlomer, H. T.; Wuttke, W. Differential response of substance P-containing subtypes of adrenomedullary cells to different stressors. Endocrinology. 123: 2140-2145; 1988.
224. Villanua, M. A.; Debeljuk, L.; Ghosh, P. K.; Bartke, A. Effects of neonatal administration of monosodium glutamate and castration on neurokinin A levels in the hypothalamus and anterior pituitary of rats. Peptides. 13:377-381; 1992.
225. Vinson, G. P.; Hinson, J. P. Blood flow and hormone secretion in the adrenal gland. In: James, V.H.T.; ed. The adrenal gland. New York: Raven Press; 1992:71-86.
226. Vinson, J. P.; Hinson, J. P.; Toth, I. E. The neuroendocrinology of the adrenal cortex. J. Neuroendocrinol. 6:235-246; 1994.
227. Vizi, E. S.; Toth, I. E.; Orso, E.; Szalay, K. S.; Szabo, D.; Barayani, M.; Vinson, G. P. Dopamine is taken up from the circulation by, and released from, local noradrenergic varicose axon terminals in zona glomerulosa of the rat: a neurochemical and immunocytochemical study. J. Endocrinol. 139:213-226; 1993.
228. Vizi, E. S.; Toth, I. E.; Szalay, K. S.; Windisch, K.; Orso, E.; Szabo, D.; Vinson, G. P. Catecholamines released from local adrenergic axon terminals are possibly involved in fine modulation of steroid secretion from zona glomerulosa cells: functional and morphological evidence. J. Endocrinol. 135: 551-561; 1992.
229. Wajiki, M.; Ogawa, A.; Fukui, J.; Komiya, I.; Yamada, T.; Maruyama, Y. Coexistence of aldosteronoma and pheochromocytoma in adrenal gland. J. Surg. Oncol. 28:75-78; 1985.
230. Wang, J. M.; De Ridder, E. F. M. M.; De Potter, W. P.; Weyns, A. L. M. Localization of neurokinin A and chromogranin A immunoreactivity in the developing porcine adrenal medulla. Histochem. J. 26:431-436; 1994.
231. Wang, Y.; Bockman, C. S.; Lovas, S.; Abel, P. W.; Murphy, R. F.; Conlon, J. M. Neuropeptide γ-[1-9] peptide: A major product of the posttranslational processing of γ-preprotachykinin in rat tissues. J. Neurochem. 61:1231-1235; 1993.
232. Warden, M. K.; Young, W. S. Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system. J. Comp. Neurol. 272:90-113; 1988.
233. Watanabe, T.; Orth, D. N. Detailed kinetic analysis of adrenocorticotropin secretion by dispersed rat anterior pituitary cells in a microperifusion system: effects of ovine corticotropin-releasing factor and arginine vasopressin. Endocrinology. 121:1133-1145; 1987.
234. Watling, K. J.; Guard, S.; Krause, J. E.; Takeda, Y.; Quirion, R.; Zarnegar, R.; Pain, D.; Franks, R. On the presence of NK2 receptor subtypes in peripheral and central tissues. Regul. Pept. 46:311-313; 1993.
235. Whitnall, M. H.; Smith, D.; Gainer, H. Vasopressin coexists in half of the corticotropin-releasing factor axons present in the external zone of the median eminence in normal rats. Neuroendocrinology. 45:420-424; 1987.
236. Winkler, A.; Papsdorf, G.; Odarjuk, J.; Siems, W. E.; Fickel, J.; Melzig, M. F. Expression and characterization of the substance P (NK1) receptor in the rat pituitary and AtT20 mouse pituitary tumor cells. Eur. J. Pharmacol. 291:51-55; 1995.
237. Yoshida, T.; Mio, M.; Tasaka, K. Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors. Biochem. Pharmacol. 43:513-517; 1992.
238. Zhou, X. F.; Marley, P. D.; Livett, B. G. Substance P modulates the time course of nicotinic but not muscarinic catecholamine secretion from perfused adrenal gland of rat. Br. J. Pharmacol. 104:159-165; 1991.
239. Zhou, X. F.; Oldfield, B. J.; Livett, B. G. Substance P-containing sensory neurons in the rat dorsal root ganglia innervate the adrenal medulla. J. Auton. Nerv. Syst. 33:247-254; 1991.
240. Zieleniewski, W.; Zieleniewski, J. Effect of neurotensin and substance P on adrenal cortex regeneration. Peptides. 16: 175-176; 1995.