Conformational stability studies of the pleckstrin DEP domain: Definition of the domain boundaries

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1385, Issue 1, 1998, Pages 157-164

  Kharrat, Abdelhakim ^a   Millevoi, Stefania ^a   Baraldi, Elena ^a   Ponting, Chris P ^b   Bork, Peer ^a,b   Pastore, Annalisa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Domain boundary; Modular protein; Pleckstrin; Thermal stability

Indexed keywords

PLECKSTRIN; PROTEIN KINASE C;

ARTICLE; CIRCULAR DICHROISM; GENETIC ENGINEERING; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; THERMOSTABILITY;

AMINO ACID SEQUENCE; BLOOD PROTEINS; CIRCULAR DICHROISM; CONSERVED SEQUENCE; ESCHERICHIA COLI; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PHOSPHOPROTEINS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 0031863027     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(98)00041-7     Document Type: Article

References (24)

1. Haslam R.J., Lynhan J.A. Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents: I. Effects of different aggregating agents. Biochem. Biophys. Res. Commun. 779:1997;714-722.
2. Tyers M., Rachubinski R.A., Stewart M.I., Varrichio A.M., Shorr R.G.L., Haslam R.J., Harley C.B. Molecular cloning and expression of the major protein kinase C substrate of platelets. Nature. 333:1988;470-473.
3. Gailani D., Fisher T.C., Mills D.C., Macfarlane D.E. P47 phosphoprotein of blood platelets (pleckstrin) is a major target for phorbol ester-induced protein phosphorylation in intact platelets, granulocytes, lymphocytes, monocytes and cultured leukaemic cells: absence of P47 in non-haematopoietic cells. Br. J. Haematol. 74(2):1990;192-202.
4. Sano K., Takai Y., Yamanishi J., Nishizuka Y. A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions. J. Biol. Chem. 258(14):1983;2010-2013.
5. Haslam R.J., Lynhan J.A., Fox J.E.B. Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets. Biochem. J. 178:1979;397-406.
6. Tyers M., Haslam R.J., Rachubinski R.A., Harley C.B. Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets. J. Cell Biochem. 40(2):1989;133-145.
7. Saraste M., Hyvvnen M. Pleckstrin homology domains: a fact file. Curr. Opin. Struct. Biol. 5(3):1995;403-408.
8. Gibson T.J., Hyvvnen M., Musacchio A., Saraste M., Birney E. PH domain: the first anniversary. Trends Biochem. Sci. 19(9):1994;349-353.
9. Harlan J.E., Hajduk P.J., Yoon H., Fesik S.W. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature. 371(6493):1994;168-170.
10. Touhara K., Inglese J., Pitcher J.A., Shaw G., Lefkowitz R.J. Binding of G protein beta gamma-subunits to pleckstrin homology domains. J. Biol. Chem. 269(14):1994;10217-10220.
11. DebBurman S.K., Ptasienski J., Boetticher E., Lomasney J.W., Benovic J.L., Hosey M.M. Lipid-mediated regulation of G protein-coupled receptor kinases 2 and 3. J. Biol. Chem. 270(11):1995;5742-5747.
12. Touhara K., Koch W.J., Hawes B.E., Lefkowitz R.J. Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. J. Biol. Chem. 270(28):1995;17000-17015.
13. Lemmon M.A., Ferguson K.M., O'Brien R., Sigler P.B., Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc. Natl. Acad. Sci. U.S.A. 92(23):1995;10472-10476.
14. Shaw G. The pleckstrin homology domain: an intriguing multifunctional protein module. Bioessays. 18(1):1996;35-46.
15. Ponting C.P., Bork P. Pleckstrin's repeat performance: a novel domain in G-protein signaling? Trends Biochem. Sci. 21(7):1996;245-246.
16. Abrams C.S., Zhao W., Belmonte E., Brass L.F. Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain. J. Biol. Chem. 270(40):1995;23317-23321.
17. Politou A., Gautel M., Pfuhl M., Labeit S., Pastore A. Immunoglobulin-type domains of titin: same folding, different stability? Biochemistry. 33:1994;4730-4737.
18. Altschul S.F., Boguski M.S., Gish W., Wootton J.C. Issues in searching molecular sequence databases. Nat. Genet. 6(2):1994;119-129.
19. Musco G., Stier G., Joseph C., Castiglione Morelli M.A., Nilges M., Gibson T.J., Pastore A. Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome. Cell. 85:1996;237-245.
20. Pfuhl M., Improta S., Politou A.S., Pastore A. When a module is also a domain: the role of the N terminus in the stability and the dynamics of immunoglobulin domains from titin. J. Mol. Biol. 265:1997;242-256.
21. Macias M.J., Hyvonen M., Baraldi E., Schultz J., Sudol M., Saraste M., Oschkinat H. Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature. 382(6592):1996;646-649.
22. McDermott A.M., Haslam R.J. Chemical cross-linking of pleckstrin in human platelets: evidence for oligomerization of the protein and its dissociation by protein kinase. Can. Biochem J. 317:1996;119-124.
23. Peranen J., Rikkonen M., Hyvonen M., Kaariainen L. T7 vectors with a modified T7lac promoter for expression of proteins in Escherichia coli. Anal. Biochem. 236:1996;371-373.
24. Birney E., Kumar S., Krainer A.R. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res. 21:1993;5803-5816.