Metabolism of 2(R,S)-1,2-Bis(nicotinamido) propane, a new agent with anti-vasospasm activity, in rats and rabbits

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 5, 1998, Pages 429-435

  Ishigai, Masaki ^a   Ishitani, Yoshihiko ^a   Orikasa, Yuko ^a   Kamiyama, Hiroshi ^a   Kumaki, Kenji ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2(R,S) 1,2 Bis(nicotinamido)propane; Anti vasospasm substance; Metabolism; Rabbits; Rats

Indexed keywords

3 CHLOROBENZOIC ACID; ALDEHYDE OXIDASE; ALLOPURINOL; DICYCLOHEXYLCARBODIIMIDE; DRUG METABOLITE; IMIDAZOLE DERIVATIVE; MENADIONE; NEW DRUG; NICARAVEN; NICOTINIC ACID METHYL ESTER; OXIDE; PYRIDONE DERIVATIVE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN VASOSPASM; CONTROLLED STUDY; DRUG EXCRETION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG OXIDATION; DRUG SYNTHESIS; DRUG URINE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; LIVER CYTOSOL; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RABBIT; RAT; SPECIES DIFFERENCE; THIN LAYER CHROMATOGRAPHY;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; ANTIOXIDANTS; BILE; BIOTRANSFORMATION; CYTOSOL; FECES; LIVER; MALE; MASS SPECTROMETRY; NIACINAMIDE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031862178     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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