Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant

American Journal of Clinical Pathology

Volumn 109, Issue 6, 1998, Pages 754-757

  Reneke, Johanna ^a,c   Etzell, Joan ^b,c   Leslie, Susan ^b,c   Ng, Valerie ^a,c   Gottfried, Eugene L ^a,c  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

109 mmol L citrate; 3.2 citrate; Activated partial thromboplastin time; APTT; International Sensitivity Index; ISI; Prothrombin time; PT; Underfill

Indexed keywords

CITRIC ACID; THROMBOPLASTIN; WARFARIN;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; LABORATORY DIAGNOSIS; ORAL DRUG ADMINISTRATION; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; TUBE; VENOUS BLOOD;

EID: 0031862104     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/109.6.754     Document Type: Article

References (7)

1. Peterson P, Gottfried EL. The effects of inaccurate blood sample volume on prothrombin time (PT) and activated partial thromboplastin time (aPTT). Thromb Haemost. 1982;47:101-103.
2. Pai SH, Michalaros K. Effect of sample volume on coagulation tests. Lab Med. 1990;21:371-373.
3. National Committee for Clinical Laboratory Standards. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and Performance of Coagulation Assays. 2nd ed. Approved Guideline. Villanova, Pa: National Committee for Clinical Laboratory Standards; 1991. NCCLS document H21-A2.
4. College of American Pathologists. Comprehensive Proficiency Testing Survey CG2-C. Northfield, Ill: College of American Pathologists; 1994.
5. Ingram GIC, Hills M. The prothrombin time test: effect of varying citrate concentration. Thromb Haemost. 1976;36:230-236.
6. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol 1997;107:105-110.
7. Duncan EM, Casey CR, Duncan BM, et al. Effect of concentration of trisodium citrate anticoagulant on calculation of the international normalised ratio and the international sensitivity index of thromboplastin. Thromb Haemost. 1994;72:84-88.