Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration

Anatomical Record

Volumn 251, Issue 2, 1998, Pages 173-180

  Calvo, Rosa Maria ^a   Forcen, Rosa ^b   Obregon, Maria Jesus ^a   Escobar Del Rey, Francisco ^a   Morreale De Escobar, Gabriella ^a   Regadera, Javier ^b,c  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Fetal beta cells; Ki 67; Maternal diabetes; Proliferating cell nuclear antigen; Proliferation

Indexed keywords

INSULIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FETUS DEVELOPMENT; HISTOGENESIS; IMMUNOHISTOCHEMISTRY; INSULIN TREATMENT; MATERNAL DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031862059     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0185(199806)251:2<173::aid-ar4>3.0.co;2-%23     Document Type: Article

References (39)

1. Aerts L, Van Assche FA. Rat fetal endocrine pancreas in experimental diabetes. J. Endocrinol. 1977;73:339-346.
2. Aerts L, Van Assche FA. Endocrine pancreas in the offspring of rats with experimentally induced diabetes. J. Endocrinol. 1981;88: 81-88.
3. Apte S. Ki-67 monoclonal antibody (mab) reacts with a proliferation associated nuclear antigen in the rabbit Oryctolagus cuniculus. Histochemistry 1990;94:201-204.
4. Baird J, Farquhar J. The insulin secreting capacity of the pancreas in the newborn infants of normal and diabetic women. Lancet 1962;1: 71-74.
5. Bowens L, Wang R, De Blay E, Pipeleers D, Kloppel G. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 1994;43:1279-1283.
6. Brown D, Gatter K. Monoclonal antibody Ki 67: Its use in histopathology. Histopathology 1990;17:489-503.
7. Calvo R, Morreale de Escobar G, Escobar del Rey F, Obregón MJ. Maternal diabetes mellitus, a rat model for non-thyroidal illness: Correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status. Thyroid 1997a;7:79-87.
8. Calvo R, Morreale de Escobar G, Escobar del Rey F, Obregón MJ. Maternal non-thyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model. Endocrinology 1997b;138:1159-1169.
9. Cantenys D, Portha B, Dutrillaux MC, Hollande E, Rozé C, Picon L. Histogenesis of the endocrine pancreas in newborn rats after destruction by streptozotocin. Vichows Arch. B Cell Pathol. 1981;35: 109-122.
10. Cordel J, Falini B, Erber W, Ghosh A, Abdulaziz Z, MacDonald S, Pulfords K, Mason D. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes). J. Histochem. Cytochem. 1981;32:219-229.
11. Daskalova R, Christova T, Petkov P. Alteration of islet cell arrangement of alloxan-diabetic rats. Verh. Anat. Ges. 1989;82:449-450.
12. Eriksson U, Swenne I. Diabetes in pregnancy: Growth of the fetal pancreatic B cells in the rat. Biol. Neonate 1982;42:239-248.
13. Eriksson U, Andersson A, Efendic S, Elde R, Hellerström C. Diabetes in pregnancy: Effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin. Acta Endocrinol. 1980;94:354-364.
14. Falini B, Flenghi L, Fagioli M, Stein H, Schwarting R, Riccardi C, Manocchio I, Pileri S, Pelicci P, Lanfrancone L. Evolutionary conservation in various mammalian species of the human proliferation-associated epitope recognized by the Ki-67 monoclonal antibody. J. Histochem. Cytochem. 1989;37:1471-1478.
15. Gerdes J, Li L, Schlueter C, Duchrow M, Wonhlenberg C, Gerlach C, Stahmer I, Kloth S, Brandt E, Flad HD. Immunochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki 67. Am. J. Pathol, 1991;138:867-873.
16. Hellerström C, Swenne I. Growth patterns of pancreatic islets in animals. In: Volk B, Arquilla E, eds. The Diabetic Pancreas. New York: Plenum Press, 1985: 53-79.
17. Herrera E, Palacín M, Martín A, Lasunción MA. Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity. Diabetes 1985;34(Suppl 2):42-46.
18. Holt P, Moss S, Kapetanakis A, Petrotos A, Wang S. Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen? Cancer Epidemiol. Biomarkers Prev. 1997;6:131-135.
19. Hsu S, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem. 1981;29:577-580.
20. Hugget A, Nixon D. Use of glucose oxidase, peroxidase and o-dianisidine in determination of blood and urinary glucose. Lancet 1957;1:368-370.
21. Junod A, Lambert A, Orci L, Pictet R, Gonet A, Renold A. Studies of the diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 1967;126:201-204.
22. Junod A, Lambert A, Stauffacher W, Renold A. Diabetogenic action of streptozotocin: Relationship of dose to metabolic response. J. Clin. Invest. 1969;48:2129-2139.
23. Kervran A, Guillaume M, Jost A. The endocrine pancreas of the fetus from diabetic pregnant rat. Diabetologia 1978;15:387-393.
24. King D, Kitchen K, Chick W. Pancreatic beta cell replication: Relation to insulin secretion. Endocrinology 1978;103:321-327.
25. Kloppel G, In't Veld P, Stamm B, Heitz P. The endocrine pancreas. In: Kovacs K, Asa S, eds. Functional Endocrine Pathology. Boston: Blackwell, 1991: 396-457.
26. Kohnert K, Falt K, Odselius R, Ziegler M, Madsen O, Grimelius L, Falfmer S. Production of pro-insulin, c-peptide, and insulin in nesidioblastosis, focal islet-cell adenomastosis, and genuine insulinomas. A correlated radioimmunochemical, immunohistochemical, and ultrastructural investigation with particular regard to the occurrence of argyrophil and pro-insulin immunoreactive cells. Diabetes Res. 1988;8:151-163.
27. Morreale de Escobar G, Pastor R, Obregón MJ, Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues. Endocrinology 1985;117: 1890-1901.
28. Obregón MJ, Ruiz de Oña C, Hernández A, Calvo RM, Escobar del Rey F, Morreale de Escobar G. Thyroid hormones and 5′-deiodinase in rat brown adipose tissue during fetal life. Am. J. Physiol. 1989; 257(Endocrinol Metab 20):E625-E631.
29. Patel YC, Cameron DP, Bankier A, Malaisse-Lagae F, Ravazzola M, Studer P, Orci L. Changes in somatostatin concentration in pancreas and other tissues of streptozotocin diabetic rats. Endocrinology 1978;103:917-923
30. Pitkin RM, van Orden DE. Fetal effects of maternal streptozotocin-diabetes. Endocrinology 1974;94:1247-1253.
31. Portha B. Development of the pancreatic β cell: Growth patterns and functional maturation. In: Cuezva, JM, Pascual-Leone AM, Patel MS, eds. Endocrine and Biochemical Development of the Fetus and Neonate. New York: Plenum Press, 1990: 33-43.
32. Portha B, Levacher C, Picon L, Rosselin G. Diabetogenic effect of streptozotocin in the rat during the perinatal period. Diabetes 1974;23:889-895.
33. Sasaki K, Kurose A, Ishida Y, Matsuta M. Estimation of S-phase fraction in tumor tissue sections by immunohistochemical staining of PCNA. J. Histochem. Cytochem. 1994;42:957-960.
34. Snedecor GW, Cochran WG. Statistical Methods. Ames: Iowa State University Press, 1980.
35. Swenne I, Eriksson U. Diabetes in pregnancy: Islet cell proliferation in the fetal rat pancreas. Diabetologia 1982;23:525-528.
36. Van Assche FA, Aerts L. Long-term effect of diabetes and pregnancy in the rat. Diabetes 1985;34(Suppl 2):116-118.
37. Van Assche FA, Aert SL, De Prins F. Degranulation of the insulin-producing beta-cells in an infant of a diabetic mother. Case report. Br. J. Obstet. Gynaecol. 1983;90:182-185.
38. Weibel E. Sterological Methods. Practical Methods for Biological Morphometry. London: Academic Press, 1979: 26-37, 360.
39. Yamamoto M, Kudoh A, Arishima K, Eguchi Y. Immunocytochemical changes in the fetal pancreatic islet following fetal administration of streptozotocin in the rat. Anat. Rec. 1997;247:248-252.