Endothelium-dependent vasorelaxant and anti-aggregatory effect and mechanism of action of some antifibrinogen RGD (Arg-Gly-Asp-containing) peptides

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 6, 1998, Pages 667-671

  Torday, Ladislaus L ^a   Pataricza, János ^a   Balogh, Gábor E ^a   Zarándi, Márta ^a   Penke, Botond ^a   Papp, Julius Gy ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; FIBRINOGEN RECEPTOR; N(G) NITROARGININE; NITRIC OXIDE; PHENYLEPHRINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; NONHUMAN; RABBIT; THORACIC AORTA; THROMBOCYTE AGGREGATION INHIBITION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0031862019     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb06903.x     Document Type: Article

References (30)

1. Alig, L., Edenhofer, A., Hadváry, P., Hürzeler, M., Knopp, D., Müller, M., Steiner, B., Trzeciak, A., Weller, T. (1992) Low molecular weight, non-peptide fibrinogen receptor agonists. J. Med. Chem. 35: 4393-4407
2. Born, G. V. R. (1962) Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature (London) 194: 927-929
3. Busse, R., Luckhoff, A., Mulsch, A. (1991) Cellular mechanism controlling EDRF/NO formation in endothelial cells. Basic. Res. Cardiol. 86 (Suppl. 2): 7-16
4. Carr, S., Farb, A., Pearce, W. H., Virmani, R., Yao, J. S. (1996) Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J. Vasc. Surg. 23: 755-765
5. Chen, G. F., Suzuki, H. (1990) Calcium dependency of the endothelium - dependent hyperpolarization in smooth muscle cells of the rabbit carotid artery. J. Physiol. (London) 421: 521-534
6. 2 fragments of a monoclonal antibody. Blood 66: 1456-1459
7. Cox, D., Aoki, T., Seki, J., Motoyama, Y., Yoshida, K. (1994) The pharmacology of the integrins. Med. Res. Rev. 14: 195-228
8. Doolittle, R. F., Watt, K. W. K., Cottrell, B. A., Strong, D. D., Riley, M. (1979) The amino acid sequence of the α-chain of human fibrinogen. Nature 280: 464-468
9. Forrester, J. S., Litvack, F., Grundfast, W. (1991) Initiating events of acute coronary arterial occlusion. Annu. Rev. Med. 42: 35-45
10. Förstermann, U., Hertting, G., Neufang, B. (1984) The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels. Br. J. Pharmacol. 81: 623-630
11. Fuster, V., Stein, B., Ambrose, J. A., Badimon, L., Badimon, J. J., Chesebro, J. H. (1990) Atherosclerotic plaque rupture and thrombosis. Evolving concepts. Circulation 82 (Suppl. II): II-47-II-59
12. Gould, R. J., Polokoff, M. A., Friedman, P. A., Huang, T.-F., Holt, J. C., Cook, J. J., Niewiarowski, S. (1990) Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc. Soc. Exp. Biol. Med. 195: 168-171
13. Hawinger, J. (1987) Formation and regulation of platelet and fibrin hemostatic plug. Human Pathol. 18: 111-122
14. Kuo, L., Davis, M. J., Chilian, W. M. (1990) Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am. J. Physiol. 259: H1063-H1070
15. 3 integrin mediates arteriolar vasodilation in response to RGD peptides. Circ. Res. 79: 821-826
16. G-nitro-arginine (L-NOARG), a novel L-arginine reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol. 99: 408-412
17. Muller, J. M., Chilian, W. M., Davis, M. J. (1997) Integrin signaling transduces shear stress-dependent vasodilation of coronary arterioles. Circ. Res. 80: 320-326
18. Penke, B., Hajnal, F., Lonovics, J., Holzinger, G., Kádár, T., Telegdy, G., Rivier, J. (1984) Synthesis of potent heptapeptide analogues of cholecystokinin. J. Med. Chem. 27: 845-849
19. Roux, S. P., Tschopp, T. B., Kuhn, H., Steiner, B., Hadváry, P. (1993) Effect of heparin, aspirin and a synthetic platelet glycoprotein IIb-IIIa receptor antagonist (Ro 43-5054) on coronary artery reperfusion and reocclusion after thrombolysis with tissue-type plasminogen activator in the dog. J. Pharmacol. Exp. Ther. 264: 501-508
20. Ruggeri, Z. M., Houghten, R. A., Russell, S. R., Zimmerman, T. S. (1986) Inhibition of platelet function with synthetic peptides designed to be high affinity antagonists of ribrinogen binding to platelets. Proc. Natl Acad. Sci. USA 83: 5708-5712
21. Sakariassen, K. S., Fressinaud, E., Girma, J. P., Baumgartner, H. R., Meyer, D. (1986) Mediation of platelet adhesion to fibrillar collagen in flowing blood by a proteolytic fragment of human von Willebrand factor. Blood 67: 1515-1518
22. Samanen, J., Ali, F., Romoff, T., Calvo, R., Sorenson, E., Vasko, J., Store, B., Berry, D., Bennett, D., Strohsacker, M., Powers, D., Stadel, J., Nichols, A. (1991) Development of a small RGD peptide fibrinogen antagonist with potent antiaggregatory activity in vitro. J. Med. Chem. 34: 3114-3125
23. Scharf, R. E., Harker, L. A. (1987) Thrombosis and atherosclerosis: regulatory role of interactions among blood components and endothelium. Blut 55: 131-144
24. v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. J. Biol. Chem. 269: 11133-11137
25. Shattil, S. J., Hoxie, J. A., Cunningham, M., Brass, L. F. (1985) Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J. Biol. Chem. 260: 11107-11114
26. Sixma, J., Nievelstein, P., Houdijk, W., van Breugel, H., Hidriks, H., de Groot, P. (1987) Adhesion of blood platelets to isolated components of the vessel wall. Ann. NY Acad. Sci. 509: 103-107
27. Torday, L., Balogh, G. E., Pataricza, J., Zarándi, M., Papp, J. Gy., Penke, B. (1993a) The vasodilator property and mechanism of action of GRGDS an Arg-Gly-Asp(RGD)-containing peptide. J. Mol. Cell. Cardiol. 25 (Suppl. I): S93
28. Torday, L., Balogh, G. E., Pataricza, J., Zarándi, M., Papp, J. Gy., Penke, B. (1993b) Ac-Gly-Arg-Gly-Asp-Ser-OH an RGD-peptide induces endothelium dependent relaxation in isolated rabbit aorta. Peptides, Chemistry, Structure, Biology. Proceedings of the 13th American Peptide Symposium. pp 475-477
29. Torday, L., Balogh, G. E., Pataricza, J., Zarándi, M., Papp, J. Gy., Penke, B. (1994) Vasorelaxant properties and mechanism of action of some RGD(Arg-Gly-Asp-containing)-peptides. J. Mol. Cell. Cardiol. 26: LXXXVI, No. 339
30. Toth, G. K., Pataricza, J., Janaky, T., Mak, M., Zarandi, M., Papp, J. G., Penke, B., (1995) Synthesis of two peptide scorpion toxins and their use to investigate the aortic tissue regulation. Peptides 16: 1167-1172