IL-10 synergizes with dexamethasone in inhibiting human T cell proliferation

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 915-919

  Brunetti, Mauro ^a,b   Colasante, Antonella ^a,b   Mascetra, Nicola ^b   Piantelli, Mauro ^a   Musiani, Piero ^a,b   Aiello, Francesca B ^a,b  

^a UNIVERSITY OF CHIETI   (Italy)

^b Laboratory of Immunopathology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MIXTURE; DRUG POTENTIATION; DRUG SCREENING; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

DEXAMETHASONE; DRUG SYNERGISM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; RNA, MESSENGER; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031861885     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Ahuja SS, Paliogianni F, Yamada H, Balow JE and Boumpas DTJ (1993) Effect of transforming growth factor-β on early and late activation events in human T cells. J Immunol 150:3109-3118.
2. Auphan N, Di Donato JA, Rosette C, Helmberg A and Karin M (1995) Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science (Wash DC) 270:286-290.
3. Barnes P-J and Adcock I (1993) Anti-inflammatory actions of steroids: Molecular mechanisms. Trends Pharmacol Sci 14:436-441.
4. Berenbaum MC (1981) Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 35:269-335.
5. Bogdan C, Paik J, Vodovotz Y and Nathan C (1992) Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-β and interleukin-10. J Biol Chem 267:23301-23308.
6. Boumpas DT, Anastassiou ED, Older SA, Tsokos GC, Nelson DL and Balow JE (1991) Dexamethasone inhibits human Interleukin 2 but not Interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest 87:1739-1747.
7. Brandes ME, Allen JB, Ogawa Y and Wahl SM (1991) Transforming growth factor β1 suppresses acute and chronic arthritis in experimental animals. J Clin Invest 87:1108-1113.
8. Bromberg JS (1995) IL-10 immunosuppression in transplantation. Curr Opin Immunol 7:639-643.
9. Brunetti M, Martelli N, Colasante A, Piantelli M, Musiani P and Aiello FB (1995) Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes. Blood 86:4199-4205.
10. Caux C, Massacrier C, Vanbervliet B, Barthelemy C, Liu YJ and Banchereau J (1994) Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int Immunol 6(8):1177-1185.
11. Chernoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Wolff SM and Dinarello CA (1995) A randomized, controlled trial of IL-10 in humans (inhibition of inflammatory cytokine production and immune responses). J Immunol 154:5492-5499.
12. Conlon K, Osborne J, Morimoto C, Ortaldo JR and Young HA (1995) Comparison of lymphokine secretion and mRNA expression in the CD45RA + and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes. Eur J Immunol 25:644-648.
13. Cups TR and Fauci AS (1982) Corticosteroid-mediated immunoregulation in man. Immunol Rev 65:133-155.
14. Daser A, Meissner N, Herz U and Renz H (1995) Role and modulation of T-cell cytokmes in allergy. Curr Opin Immunol 7:762-770.
15. Delvaux A, Donckier V, Bruyns C, Florquin S, Gerard C, Amraoui Z, Abramowicz D, Goldman M and Velu T (1994) Effects of systemic administration of rIL-10 in an in viuo model of alloreactivity. Transplantation (Balto) 58:972-974.
16. de Waal Malefyt R, Yssel H and de Vries JE (1993) Direct effect of IL-10 on subsets of human CD4+ T cell clones and resting T cells. J Immunol 150:4754-4765.
17. Ding L and Shevach EM (1992) IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 148:3133-3139.
18. Groux H, Bigler M, de Vries JE and Roncarolo MG (1996) Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 184:19-29.
19. Holter W, Majdic O, Kalthoff FS and Knapp W (1992) Regulation of interieukin-4 production in human mononuclear cells. Eur J Immunol 22:2765-2767.
20. Huhn RD, Radwanski E, O'Connell SM, Sturgill MG, Clarke L, Cody RP, Affrime MB and Cutler DL (1996) Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers. Blood 87:699-705.
21. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB and Fauci AS (1986) Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037-1057.
22. Mignon-Godefroy K, Rott O, Brazillet MP and Charreire J (1995) Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT) (evidence for IL-10-enhanced cell death in EAT). J Immunol 154:6634-6643.
23. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P and Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11:165-190.
24. kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (Lond) 372:570-573.
25. Pajktr D, Camoglio L, Tiel-van Buul MCM, de Bruin K, Cutler DL, Affrime MB, Rikken G, van der Poll T, ten Gate JW and Deventer SJH (1997) Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia. J Immunol 158:3971-3977.
26. Paliogianni F, Ahuja SS, Balow JP and Boumpas DT (1993a) Novel mechanism for inhibition of human T cell by glucocorticoids. J Immunol 151:4081-4089.
27. Paliogianni F, Raptis A, Ahuja SS, Najjar SM and Boumpas DT (1993b) Negative transcriptional regulation of human Interleukin 2 (IL-2) gene by glucocorticoids through interference with transcription factors AP-1 and NF-AT. J Clin Invest 91:1481-1489.
28. Quin L, Chavin KD, Ding Y, Favaro JP, Woodward JE, Lin J, Tahara H, Robbins P, Shaked A, Ho DY, Sapolsky RM, Lotze MT and Bromberg J (1995) Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. (Immunosuppression with TGF-β1 or vIL-10). Transplantation (Balt.) 59:809-816.
29. Racke MK, Dhib-Jalbut S, Cannella B, Albert PS, Raine C and McFarlin DE (1931) Prevention and treatment of chronic relapsing allergic encephalomyelitis by transforming growth factor β1. J Immunol 146:3012-3017.
30. Romano MF, Lamberti A, Petrella A, Bisogni R, Tassone PF, Formisano S, Venuta S and Turco MC (1996) IL-10 inhibits Nuclear Factor-kB/Rel nuclear activity in CDS-stimulated human peripheral T lymphocytes. J Immunol 156:2119-2123.
31. Rott O, Fleischer B and Cash E (1994) Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24:1434-1440.
32. Saltis J (1996) TGF-β: Receptors and cell cycle arrest. Mol Cell Endocr 116:227-232.
33. Santambrogio L, Hochwald GM, Saxena B, Leu CH, Martz JE, Carlino JA, Ruddle NH, Palladino MA, Gold LI and Thorbecke GJ (1993) Studies on the mechanisms by which transforming growth factor-β (TGF-β) protects against allergic encephalomyelitis. J Immunol 151:1116-1127.
34. Schwartzmann RA and Cidlowski JA (1994) Glucocorticoid-induced apoptosis of lymphoid cells. Int Arch Allergy Immunol 105:347-354.
35. Taga K, Mostowski H and Tosato G (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81:2964-2971.
36. Taga K and Tosato G (1992) IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 148:1143-1148.
37. Vacca A, Felli MP, Farina AR, Martinotti S, Maroder M, Screpanti AR, Meco D, Petrangeli E, Frati L and Gulino A (1992) Glucocorticoid receptor-mediated suppression of the Interleukin 2 gene expression through impairment of the cooper-ativity between Nuclear Factor of Activated T cells and AP-1 enhancer elements. J Exp Med 175:637-646.
38. Wahl SM, Hunt DA, Wong HL, Dougherty S, McCartney-Francis N, Wahl LM, Ellingsworth L, Schmidt JA, Hall G, Roberts AB and Sporn MB (1988) Transforming growth factor-β is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J Immunol 140:3026-3032.
39. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN and Feldmann M (1996) Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum 39:495-503.