Fractional absorption of L-carnitine after oral administration in rats: Evaluation of absorption site and dose dependency

Biological and Pharmaceutical Bulletin

Volumn 21, Issue 7, 1998, Pages 752-755

  Matsuda, Kenji ^a   Yuasa, Hiroaki ^a   Watanabe, Jun ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Dose dependency; Fractional absorption; L carnitine; Large intestine; Rat; Small intestine

Indexed keywords

CARNITINE; MACROGOL 4000;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG TRANSPORT; INTESTINE ABSORPTION; INTESTINE MUCOSA; MITOCHONDRIAL MEMBRANE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0031859410     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.21.752     Document Type: Article

References (20)

1. Rebouche C. J., Ann. Rev. Nutr., 6, 41-66 (1986).
2. Roe C. R., Millington D. S., Maltby D. A., Bohan T. P., Hoppel C. L., J. Clin. Invest., 73, 1785-1788 (1984).
3. Shimura S., Hasegawa T., J. Vet. Med. Sci., 55, 845-847 (1993).
4. Segre G., Bianchi E., Corsi M., D'Iddio S., Ghirardi O., Maccari F., Arzneim.-Forsch., 38, 1830-1834 (1988).
5. Harper P., Elwin C.-E., Cederblad G., Eur. J. Clin. Pharmacol., 35, 555-562 (1988).
6. Rebouche C. J., Mack D. L., Edmonson P. F., Biochemistry, 23, 6422-6426 (1984).
7. McCloud E., Ma T. Y., Grant K. E., Mathis R. K., Said H. M., Gastroenterology, 111, 1534-1540 (1996).
8. Hamilton J. W., Li B. U. K., Shug A. L., Olsen W. A., Gastroenterology, 91, 10-16 (1986).
9. Shaw R. D., Li B. U. K., Hamilton J. W., Shug A. L., Olsen W. A., Am. J. Physiol., 245, G376-G381 (1983).
10. Gudjonsson H., Li B. U. K., Shug A. L., Olsen W. A., Gastroenterology, 88, 1880-1887 (1985).
11. Matsuda K., Yuasa H., Watanabe J., Biopharm. Drug Dispos., in press.
12. Yuasa H., Numata W., Ozeki S., Watanabe J., J. Pharm. Sci., 84, 476-481 (1995).
13. Yuasa H., Kuno C., Watanabe J., J. Pharm. Pharmacol., 49, 26-29 (1997).
14. Rebouche C. J., Metabolism, 40, 1305-1310 (1991).
15. Yuasa H., Kuno C., Watanabe J., Biol. Pharm. Bull., 19, 604-607 (1996).
16. Gudjonsson H., Li B. U. K., Shug A. L., Olsen W. A., Am. J. Physiol., 248, G313-G319 (1985).
17. Gross C. J., Henderson L. M., Biochim. Biophys. Acta, 772, 209-219 (1984).
18. Gross C. J., Henderson L. M., Savaiano D. A., Biochim. Biophys. Acta, 886, 425-433 (1986).
19. Li B. U. K., Lloyd M. L., Gudjonsson H., Shug A. L., Olsen W. A., Am. J. Clin. Nutr., 55, 838-845 (1992).
20. Ritschel W. A., Meth. Find. Exp. Clin. Pharmacol., 13, 313-336 (1991).