Provisional experience with procalcitonin, C-reactive protein, neopterin, selected cytokines, and hemostatic parameters in patients with malignant hematological diseases and febrile neutropenia induced by cytostatic treatment;Vorlaufige Erfahrungen mit Procalcitonin, C-reaktivem Protein, Neopterin, ausgewahlten Zytokinen und Hamostaseparametern an Patienten mit malignen hamatologischen Erkrankungen, bei Zytostatika-induzierter Neutropenie und Fieber

Clinical Laboratory

Volumn 44, Issue 6, 1998, Pages 451-461

  Lestin, Franka ^b,c   Lestin, Heiko Gundmar ^a   Burstein, Christine ^b   Anders, O ^b   Freund, M ^b  

^a Klinikum Schwerin

^b UNIVERSITY OF ROSTOCK   (Germany)

^c Klinikum Schwerin   (Germany)

Author keywords

CRP; Cytostatic therapy; IL 1; IL 6; Neopterin; Neutropenia; Procalcitonin; Sepsis; SIRS; Systemic hematological disease; THF

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; CYTOSTATIC AGENT; GRANULOCYTE COLONY STIMULATING FACTOR; NEOPTERIN; PREDNISONE; PROCALCITONIN;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; FEVER; HEMATOLOGIC DISEASE; HEMOSTASIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NEUTROPENIA;

EID: 0031859280     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Berenguer J. Diaz, Mediavilla J, Martinez R, Fernandez A, del Potro E, Munoz P. Infectious complications in neutropenic patients with malignant hemopathies. A prospective study of 279 cases of neutropenia. Med. Clin. (Barc) 95 1990: 13: 481 - 485
2. Bone RC. Let's agree on terminology: definitions of sepsis. CritCare Med 1991; 19: 973 - 976
3. Bone RC. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA 1992; 268: 3452 - 3455
4. Chen YM, Wang-Peng J,Chem CH, Kuo B, Wang SY, Perng RP. Elevation of serum IL-6 levels in patients with acute bacterial infection. Chin Med J 1995; 56: 239 - 243
5. Fischler MP, Reinhart WH. Fieber Freund oder Feind?. Schweiz Med Wochenschr 1997; 127: 864 - 870
6. Guitierrez J, Bronfman L, Lorca J, Pinto ME, Torrens M, Barcia ME, Barrientos A, Palma T. Infection in severe neutropenia: analysis of 140 episodes. Rev Med Chil 1989; 117 (10):1141 - 1149
7. Murray HW. FUO: Fever of undertermined origin. Futura Publishing Company. Mount Kisco, N.Y. 1983
8. Pizzo PA. Management of fever in patients with cancer and treatment-induced neutropenia. New Eng J Med ; 328 (18):1323 - 1329
9. Yokota T, Shishime E, Okayama A, Ishizaki J, Murai K, Shioiri S, Tachibana N, Tsuda K. Infections in hematological malignancies - clinical analysis of septic patients admitted to the Second Department of Miyazaki Medical Hospital in the past ten years. Kansenshogaku Zasshi 1990; 64 (6): 653 - 660
10. Chen YM, Whang-Peng J, Chem CH, Ing-Tiau Kuo B, Wang SJ, Perng RP. The prognostic value of serum cytokine levels in patients with acute infections. Chin Med J 1995; 56: 76 - 79
11. Broug-Holub E, Persoons JHA, Schomagel K, Kraal G. Changes in cytokine and nitric oxide secretion by rat alveolar macrophages after oral adiministration of bacterial extracts. Clin Exp Immunol 1995; 101: 302 - 307
12. Sautner T, Fugger R, Götzinger P, Mittlböck M, Winkler S, Roth E, Steininger R, Muhlbacher F. Tumour necrosis factor-α and interleukin-6: early indicators of bacterial infection after human orthotopic liver transplantation. Eur J Surg 1995; 161: 97 - 101
13. Hack CE, de Groot ER, Richelle JF, Felt-Bersma, Juijens JH, Rob JM, Strack, van Schinjndel, Ankte JM, Erenberg-Belmer, Lambertus GT, Aarden LA. Increased plasma levels of interleukin-6 in sepsis. Blood 1989; 5: 1704 - 1710
14. Ostermann H, Rothenburger M, Mesters RM, van de Loo J, Kienast J. Cytokine response to infection in patients with acute myelogenous leukaemia following intensive chemotherapy. Br J Haematol 1994; 88: 332 - 337
15. Herrmann JL, Blanchard H, Brunengo P, Lagrange PH. TNFα , IL-1β and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with the C-reactive protein (CRP) kinetic values. Infection 1994; 5
16. Waage A, Steinshamn S. Cytokine mediators of septic infections in the normal and granulocytopenic host. Eur J Haematol 1993; 50: 243 - 249
17. Schonbohn H, Schuler M, Kolbe K, Peschel C, Huber C, Bemb W, Aulitzky WE. Plasma levels of IL-I. TNF alpha, IL-6,. IL-8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia. Ann Hematol 1995; 71: 161 - 168
18. Engervall P, Andersson B, Björkholm M. Clinical significance of serum cytokine patterns during start of fever in patients with neutropenia. Br J Haematol 1995; 91: 838 - 845
19. Riikonen P, Saarine UM, Teppo AM, Metsärinne K, Fyhrquist F, Jalanko H. Cytokine and acute-phase reactant levels in serum of children with cancer admitted for fever and neutropenia. J Infect Dis 1992; 166: 432 - 436
20. Heney DE, Lewis IJ, Evans SW, Banks R, Bailey CC, Whicher JT. Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia. J Infect Dis 1992; 165: 886 - 890
21. Engel A, Kern WV, Mürdter G, Kern P. Kinetics and correlation with body temperature of circulating interleukin-6, interleukin-8, rumor necrosis factor alpha and interleukin-1 beta in patients with fever and neutropenia. Infection 1994; 3
22. Günther G, Gardlung B, Hast R, Kimby E, Nordin M, Wretlind B. Endotoxaemia and inflammatory mediators in febrile patients with haematological disease. J Intern Med 1995; 27 - 33
23. Nylen ES, Neill WO, Jorgan MH, Snider RH, Moore DF, Lewis M, Silva OL, Becker KL. Serum procalcitonin as an index of inhalation injury in bums. Horm metab Res 1992; 24: 439 - 442
24. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341: 515-518
25. Baier W, Procalcitonin (ProCT) - ein innovativer Inflammationsparameter mit prognostischen Eigenschaften. Anästh Intensivmed 1995; 3
26. Gramm HJ, Zimmermann J, Dollinger P, Schumann RR, Steinhoff D, Beier W. Prokalzitonin (ProCT) ist ein innovativer Marker der Akute-Phase-Reaktion bei Patienten mit Sepsis und Peritonitis
27. Gramm HI, Beier W, Zimmermann J, Qedra N, Hannemann L, Boese-Landgraf J. Procalcitonin (ProCT) -a biological marker of the inflammatory response with prognostic properties
28. Reith HB, Kaman S, Mittelkotter U, Kozuschek W. Procalcitonin - ein Parameter für die Diagnostik des septischen Verlaufs. Chir Gastroenterologie 1995; 11
29. Cheval C, Timist JF, Assicot M, Misset B, Carlet J, Bohuon C. Procalcitonin:marker of sepsis, inflammation, or both? Presented at the 8 th European Congress of Intensive Care Medicine Athens, Oct 18 - 22, 1995
30. Brunkhorst FM, Forycki ZF, Beier W, Wagner J. Procalcitonin immunoreactivity in severe human shock. Presented at the 8 th European Congress of Intensive Care Medicine, Athens, Oct 18-22, 1995
31. Brunkhorst FM, Forycki ZF, Beier W, Wagner J. Early identification of biliary pancreatitis with procalcitonin - a new inflammatory parameter. Presented at the 4th United European Gastroenterology Week-50th Annual Meeting of the German Society of Gastroenterology and Metabolism with Section for Gastroenterologic Endoscopy, Berlin. Sept 17 - 21,1995
32. Brunkhorst FM, Forycki ZF, Wagner J. Frtihe Unterscheidung von septisch und nicht-septisch bedingtem akutem Lungenversagen (ARDS) durch Procalcitonin (ProCT) Immunreaktivität. Präsentiert auf der 27. Jahrestagung d. Deutsch.Gesell. f. internistische Imensivmed. u. Notfallmed. und d. Österr. Gesell. f. allg. u. internistische Intensivmed., Intensivmed heute u. morgen Berlin, Oct 4-7, 1995
33. Staehler M, Hammer C. Procalcitonin (PCT) as a postoperative marker for the differentiation of acute rejection versus bacterial or fungal infection in heart and liver transplant patients.
34. Brunkhorst FM, Forycki ZF, Wagner J: Lebensbedrohliches Glottisödem und pulmonales Hyperpermeabilitätsödem (ARDS) nach Enalapril-Exposition - Differentialdiagnostische Bedeutung der Procalcitonin -(Pro-CT) Immunreaktivität. Präsentiert auf der 27. Jahrestagung d. Deutsch.Gesell. f. internistische Intensivmed. u. Notfallmed. und d. Österr. Gesell. f. allg. u. internistische Intensivmed., Intensivmed. heute u. morgen, Berlin, Oct 4-7, 1995
35. Garard Y, Hober D, Petitjean S, Assicoi M., Bohuon C, Mouton Y, Wattre P. High serum procalcitonin level in a 4-year-old liver transplant recipient with a disseminated candidiasis. Infection 1995; 23(5)
36. Bohuon C, Petitjean S, Assicot M. Blood procalcitonin is a new biological marker of the human septic response, new data on the specificity. Clin Intensive Care 1994; 5(2)
37. Becker KL, Nylen ES, Thrompson KA, Rohatgi P, Snider RH. Preferential hypersecretion of procalcitonin and its precursors in pneumotitis: a cytokine-induced phenomenon? Presented at the Endotoxemia & Sepsis Congress. Philadelphia, June 19 - 20, 1995
38. Gendrel D, Raymond J, Assicot M, Moulin F, Bergeret M, Badoual J, Bohuon C. Procalcitonin in bacterial and viral meningitis in children.
39. Meisner M, Tschaikowsky K, Höfig J, Prudlo U. Procalcitonin in septic shock: specific organ response or epiphenomenon of multiendocrine reaction? 5-th Vienna Shock Forum, Vienna, Austria May 7-11, 1995 (Abstract)
40. Leon A, Lepouse C, Cousson J, Raclot P, Suinat JL, Assicot M, Bohuon C. Procalcitonin concentrations in pleural effusion as a marker of human septic response. Presented at the 5th Vienna Shock Forum, Vienna/Austria, May 7-11, 1995
41. Jülien WD, Beier W, Daut M, Bahlmann G. Procalcitonin- und Neopterinbestimmung bei Dialysepatienten. (Abstract) 3. Kongr. d. Gesellschaft für Hygiene u. Umwehmedizin, Dresden, 1995
42. Assicot A, Mackensen A, Petitjean S, Engelhardt R, Bohuon C. Induction of circulating procalcitonin following intravenous administration of endotoxin in humans. Presented at the International Conference on Endotoxins Amsterdam, April, 1993
43. Assicot M, Mackensen A, Petitjean S, Engelhardt R, Bohuon C: Kinetics of the appearance of procalcitonin following endotoxin administration, (in Press)
44. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, Bohuon C. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994; 5: 1605 - 1608
45. th Annual Meeting of the Endocrine Society, Washington, June14-17, 1995
46. O'Neill WJ, Jordan MH, Lewis MS. Serum calcitonin may be a marker for inhalation injury in bums. J Bum Care 1992; 13(6): 605-616
47. Wade JC, Schimpf SC, Rubin RH, Young LS. Clinical approach to infection in the compromised host. 2.Epidemiology and prevention of infection in the compromised host. Plenum. New York 1988; pp.5-40
48. Seeber S, Schütte J: Therapiekonzepte Onkologie. Springer. Berlin 1993
49. Meisner M: Procalcitonin - ein neuer, innovativer Infektions-parameter. Brahms-Diagnostica, Berlin 1996
50. Brunkhorst et al: Identification of immune activation of infectious origin by PCT immunoreactivity in different body fluids. Presented at the Congress of Anesthesia and Intensive Care Medicine, Jena, Januar 1996