Cerebral blood flow and CO2 reactivity is similar during remifentanil/N2O and fentanyl/N2O anesthesia

Anesthesiology

Volumn 89, Issue 2, 1998, Pages 358-363

  Ostapkovich, Noeleen D ^a   Baker, Kristy Z ^b   Fogarty Mack, Patricia ^c   Sisti, Michael B ^a   Young, William L ^a  

^a Columbia University ^*  (United States)

^b FLORIDA HOSPITAL   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cerebral blood flow; CO2 reactivity; Fentanyl; Remifentanil

Indexed keywords

ANESTHETIC AGENT; CARBON DIOXIDE; FENTANYL; FENTANYL CITRATE; MIDAZOLAM; MU OPIATE RECEPTOR AGONIST; NITRIC OXIDE; OPIATE; PANCURONIUM; REMIFENTANIL; THIOPENTAL;

ADULT; ANESTHESIA INDUCTION; ARTICLE; BRAIN BLOOD FLOW; CARBON DIOXIDE MEASUREMENT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CRANIOTOMY; DOUBLE BLIND PROCEDURE; FEMALE; GENERAL ANESTHESIA; HUMAN; HUMAN TISSUE; HYPOCAPNIA; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROSURGERY; OPERATION DURATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

ADULT; ANESTHESIA, GENERAL; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; DOUBLE-BLIND METHOD; FEMALE; FENTANYL; HUMANS; MALE; MIDDLE AGED; NITROUS OXIDE; PIPERIDINES;

EID: 0031859034     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199808000-00011     Document Type: Article

References (16)

1. Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ: Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics. J Med Chem 1991; 34:2202-8
2. Glass PSA, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D: Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: Remifentanil (G187084B). Anesth Analg 1993; 77:1031-40
3. Westmorland CL, Hoke JF, Sebel PS, Hug CC Jr, Muir KT: Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. ANESTHESIOLOGY 1993; 79:893-903
4. Baker KZ, Ostapkovich N, Sisti MB, Warner DS, Young WL: Intact cerebral blood flow reactivity during remifentanil/nitrous oxide anesthesia. J Neurosurg Anesth 1997; 9:134-40
5. McClain DA, Hug CC Jr: Intravenous fentanyl kinetics. Clin Pharmacol Ther 1980; 28:106-14
6. From RP, Warner DS, Todd MM, Sokoll MD: Anesthesia for craniotomy: A double-blind comparison of alfentanil, fentanyl, and sufentanil. ANESTHESIOLOGY 1990; 73:896-904
7. Todd MM, Warner DS, Sokoll MD, Maktabi MA, Hindman BJ, Scamman FL, Kirschner J: A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide. [See editorial by Lanier WL, pp 1001-1004; see Hartung J, Cottrell JE comments in ANESTHESIOLOGY 1993 Nov; 79(5):1155-6]. ANESTHESIOLOGY 1993; 78:1005-20
8. Guy J, Hindman BJ, Baker KZ, Borel CO, Maktabi M, Ostapkovich N, Kirchner J, Todd MM, Fogarty Mack P, Yancy V, Sokoll MD, McAllister A, Roland C, Young WL, Warner DS: Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions. ANESTHESIOLOGY 1997; 86:514-23
9. 133Xe cerebral blood flow measurements by intravenous versus intracarotid methods. ANESTHESIOLOGY 1990; 73:637-43
10. 133Xe clearance, Functional Radionuclide Imaging of the Brain. Edited by Magistretti PL. New York, Raven Press, 1983, pp 87-115
11. Prohovnik I, Knudsen E, Risberg J: Theoretical evaluation and simulation test of the Initial Slope Index for noninvasive rCBF, Cerebral Blood Flow and Metabolism Measurement. Edited by Hartmann A, Hoyer S. Berlin, Springer Verlag, 1985, pp 56-60
12. Young WL, Prohovnik I, Correll JW, Ornstein E, Matteo RS, Ostapkovich N: Cerebral blood flow and metabolism in patients undergoing anesthesia for carotid endarterectomy: A comparison of isoflurane, halothane, and fentanyl. Anesth Analg 1989; 68:712-7
13. Ornstein E, Young WL, Fleischer LH, Ostapkovich N: Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions. ANESTHESIOLOGY 1993; 79:498-502
14. Young WL, Prohovnik I, Correll JW, Ostapkovich N, Ornstein E, Matteo RS, Baker KZ: A comparison of the cerebral hemodynamic effects of sufentanil and isoflurane in humans undergoing carotid endarterectomy. ANESTHESIOLOGY 1989; 71:863-9
15. Hoffman WE, Cunningham F, James MK, Baughman VL, Albrecht RF: Effects of remifentanil, a new short-acting opioid, on cerebral blood flow, brain electrical activity, and intracranial pressure in dogs anesthetized with isoflurane and nitrous oxide. ANESTHESIOLOGY 1993; 79:107-13
16. Michenfelder JD, Milde JH: The relationship among canine brain temperature, metabolism, and function during hypothermia. ANESTHESIOLOGY 1991; 75:130-6