메뉴 건너뛰기




Volumn 4, Issue 4, 1998, Pages 350-357

The molecular basis of haemophilia B

Author keywords

Factor IX; Genetics; Haemophilia B; Molecular biology

Indexed keywords

BLOOD CLOTTING FACTOR 9;

EID: 0031858612     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.1998.440350.x     Document Type: Conference Paper
Times cited : (46)

References (71)
  • 1
    • 0029790560 scopus 로고    scopus 로고
    • The factor IX gene as a model for analysis of human germline mutations: An update
    • Sommer SS, Ketterling RP. The factor IX gene as a model for analysis of human germline mutations: an update. Hum Mol Genet 1996; 5: 1505-14.
    • (1996) Hum Mol Genet , vol.5 , pp. 1505-1514
    • Sommer, S.S.1    Ketterling, R.P.2
  • 2
    • 0028959005 scopus 로고
    • Regulatory mechanism of the factor IX gene
    • Kurachi K, Kurachi S. Regulatory mechanism of the factor IX gene. Thromb Haemost 1995; 73: 333-9.
    • (1995) Thromb Haemost , vol.73 , pp. 333-339
    • Kurachi, K.1    Kurachi, S.2
  • 4
    • 78651020237 scopus 로고
    • A new estimate of the linkage between the genes for colour blindness and haemophilia in man
    • Haldane JBS, Smith CAB. A new estimate of the linkage between the genes for colour blindness and haemophilia in man. Ann Eugen 1947; 14: 10-31.
    • (1947) Ann Eugen , vol.14 , pp. 10-31
    • Haldane, J.B.S.1    Smith, C.A.B.2
  • 5
    • 77049313451 scopus 로고
    • Ueber eine besondere form hamorrhagischer diathese
    • Koller. Ueber eine besondere form hamorrhagischer diathese. Schweizerischen medizinischen Wochenschrift 1950; 80: 1101-20.
    • (1950) Schweizerischen Medizinischen Wochenschrift , vol.80 , pp. 1101-1120
    • Koller1
  • 7
    • 0029129325 scopus 로고
    • The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates
    • Walker I, Pai M, Akabutu J, Ritchie B, Growe G, Poon MC, Card R, et al. The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates. Transfusion 1995; 35: 548-51.
    • (1995) Transfusion , vol.35 , pp. 548-551
    • Walker, I.1    Pai, M.2    Akabutu, J.3    Ritchie, B.4    Growe, G.5    Poon, M.C.6    Card, R.7
  • 8
    • 0018350608 scopus 로고
    • Relationship of factor IX antigen and coagulant in haemophilia B patients and carriers
    • Pechet L, Tiarks CY, Stevens J, Sudhindra RR, Lipworth L. Relationship of factor IX antigen and coagulant in haemophilia B patients and carriers. Thromb Haemost 1978; 40: 465-77.
    • (1978) Thromb Haemost , vol.40 , pp. 465-477
    • Pechet, L.1    Tiarks, C.Y.2    Stevens, J.3    Sudhindra, R.R.4    Lipworth, L.5
  • 9
    • 0343941338 scopus 로고
    • Isolation and characterisation of a cDNA coding for human factor IX
    • Kurachi K, Davie EW. Isolation and characterisation of a cDNA coding for human factor IX. Proc Natl Acad Sci USA 1982; 79: 6461-4.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 6461-6464
    • Kurachi, K.1    Davie, E.W.2
  • 10
    • 0019957533 scopus 로고
    • Molecular cloning of the gene for human anti-haemophilia factor IX
    • Choo KH, Gould KG, Rees DJG, Brownlee GG. Molecular cloning of the gene for human anti-haemophilia factor IX. Nature 1982; 299: 178-80.
    • (1982) Nature , vol.299 , pp. 178-180
    • Choo, K.H.1    Gould, K.G.2    Rees, D.J.G.3    Brownlee, G.G.4
  • 11
    • 0019188929 scopus 로고
    • Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation
    • Pai GS, Sprenkle JA, Do TT, Mareni CE, Migeon BR. Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation. Proc Natl Acad Sci USA 1980; 77: 2810-13.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 2810-2813
    • Pai, G.S.1    Sprenkle, J.A.2    Do, T.T.3    Mareni, C.E.4    Migeon, B.R.5
  • 13
    • 0024077350 scopus 로고
    • Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients
    • Anson DS, Blake DJ, Winship PR, Birnbaum D, Brownlee GG. Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients. EMBO J 1988; 7: 2795-9.
    • (1988) EMBO J , vol.7 , pp. 2795-2799
    • Anson, D.S.1    Blake, D.J.2    Winship, P.R.3    Birnbaum, D.4    Brownlee, G.G.5
  • 15
    • 0025160041 scopus 로고
    • Localization of transcription initiation sites in the human coagulation factor IX gene
    • Reijnen MJ, Bertina RM, Reitsma PH. Localization of transcription initiation sites in the human coagulation factor IX gene. FEBS Let 1990; 270: 207-10.
    • (1990) FEBS Let , vol.270 , pp. 207-210
    • Reijnen, M.J.1    Bertina, R.M.2    Reitsma, P.H.3
  • 17
    • 0023640864 scopus 로고
    • The propeptide region of clotting Factor DC is a signal for a vitamin K dependent carboxylase: Evidence from protein engineering of amino acid -4
    • Galeffi P, Brownlee GG. The propeptide region of clotting Factor DC is a signal for a vitamin K dependent carboxylase: evidence from protein engineering of amino acid -4. Nucleic Acids Res 1987; 15: 9505-13.
    • (1987) Nucleic Acids Res , vol.15 , pp. 9505-9513
    • Galeffi, P.1    Brownlee, G.G.2
  • 19
    • 0029050220 scopus 로고
    • The role of the second growth-factor domain of human factor IXa in binding to platelets and in factor-X activation
    • Ahmad SS, Rawala R, Cheung WF, Stafford DW, Walsh PN. The role of the second growth-factor domain of human factor IXa in binding to platelets and in factor-X activation. Biochem J 1995; 310: 427-31.
    • (1995) Biochem J , vol.310 , pp. 427-431
    • Ahmad, S.S.1    Rawala, R.2    Cheung, W.F.3    Stafford, D.W.4    Walsh, P.N.5
  • 20
    • 0022257323 scopus 로고
    • Nucleotide sequence of the gene for human factor IX (antihaemophilic factor B)
    • Yoshitake S, Schach BG, Foster DC, Davie EW, Kurachi W. Nucleotide sequence of the gene for human factor IX (antihaemophilic factor B). Biochem J 1985; 24: 3736-50.
    • (1985) Biochem J , vol.24 , pp. 3736-3750
    • Yoshitake, S.1    Schach, B.G.2    Foster, D.C.3    Davie, E.W.4    Kurachi, W.5
  • 21
    • 0021340565 scopus 로고
    • Characterisation and use of an intragenic polymorphic marker for detection of carriers of haemophilia B (factor IX deficiency)
    • Giannelli F, Choo KH, Winship PR. Characterisation and use of an intragenic polymorphic marker for detection of carriers of haemophilia B (factor IX deficiency). Lancet 1984; 1: 239-41.
    • (1984) Lancet , vol.1 , pp. 239-241
    • Giannelli, F.1    Choo, K.H.2    Winship, P.R.3
  • 22
    • 0021760755 scopus 로고
    • Carrier detection in haemophilia B using two further intragenic restriction fragment length polymorphisms
    • Winship PR, Anson DS, Rizza CR, Brownlee GG. Carrier detection in haemophilia B using two further intragenic restriction fragment length polymorphisms. Nucleic Acids Res 1984; 12: 8861-8.
    • (1984) Nucleic Acids Res , vol.12 , pp. 8861-8868
    • Winship, P.R.1    Anson, D.S.2    Rizza, C.R.3    Brownlee, G.G.4
  • 23
    • 0022472262 scopus 로고
    • Use of a BamHI polymorphism in the factor IX gene for the determination of haemophilia B carrier status
    • Hay CW, Robertson KA, Yong SL, Thompson AR, Growe GH, MacGillivray RTA. Use of a BamHI polymorphism in the factor IX gene for the determination of haemophilia B carrier status. Blood 1986; 67: 1508-11.
    • (1986) Blood , vol.67 , pp. 1508-1511
    • Hay, C.W.1    Robertson, K.A.2    Yong, S.L.3    Thompson, A.R.4    Growe, G.H.5    MacGillivray, R.T.A.6
  • 24
    • 0027207410 scopus 로고
    • An Msel RFLP in the 5′ flanking region of the factor IX gene: Its use for haemophilia B carrier detection in Caucasian and Thai populations
    • Winship PR, Nichols CE, Chuansumrit A, Peake IR. An Msel RFLP in the 5′ flanking region of the factor IX gene: Its use for haemophilia B carrier detection in Caucasian and Thai populations. Br J Haematol 1993; 84: 101-5.
    • (1993) Br J Haematol , vol.84 , pp. 101-105
    • Winship, P.R.1    Nichols, C.E.2    Chuansumrit, A.3    Peake, I.R.4
  • 26
    • 0026535384 scopus 로고
    • Registry of DNA polymorphisms within or close to the human factor VIII and factor IX genes - For the Factor VIII/IX Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
    • Peake I. Registry of DNA polymorphisms within or close to the human factor VIII and factor IX genes - For the Factor VIII/IX Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1992; 67: 277-80.
    • (1992) Thromb Haemost , vol.67 , pp. 277-280
    • Peake, I.1
  • 28
    • 0025950099 scopus 로고
    • The varying frequencies of five DNA polymorphisms of X-linked coagulant factor IX in eight ethnic groups
    • Graham JB, Kunkel GR, Egilmez NK, Wallmark A, Fowlkes DM, Lord ST. The varying frequencies of five DNA polymorphisms of X-linked coagulant factor IX in eight ethnic groups. Am J Hum Genet 1991; 49: 537-44.
    • (1991) Am J Hum Genet , vol.49 , pp. 537-544
    • Graham, J.B.1    Kunkel, G.R.2    Egilmez, N.K.3    Wallmark, A.4    Fowlkes, D.M.5    Lord, S.T.6
  • 29
  • 30
    • 0024605060 scopus 로고
    • Direct detection of point mutations by mismatch analysis: Application to haemophilia B
    • Montandon AJ, Green PM, Giannelli F, Bentley DR. Direct detection of point mutations by mismatch analysis: application to haemophilia B. Nucleic Acids Res 1989; 17: 3347-58.
    • (1989) Nucleic Acids Res , vol.17 , pp. 3347-3358
    • Montandon, A.J.1    Green, P.M.2    Giannelli, F.3    Bentley, D.R.4
  • 32
    • 0027474512 scopus 로고
    • Propeptide processing during factor DC biosynthesis. Effect of point mutations adjacent to the propeptide cleavage site
    • Bristol JA, Furie BC, Furie B. Propeptide processing during factor DC biosynthesis. Effect of point mutations adjacent to the propeptide cleavage site. J Biol Chem 1993; 268: 7577-84.
    • (1993) J Biol Chem , vol.268 , pp. 7577-7584
    • Bristol, J.A.1    Furie, B.C.2    Furie, B.3
  • 34
    • 0030997346 scopus 로고    scopus 로고
    • Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
    • Snyder RO, Miao CH, Patijn GA, Spratt SK, Danos O, Nagy D, Gown AM, et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet 1997; 16: 270-6.
    • (1997) Nat Genet , vol.16 , pp. 270-276
    • Snyder, R.O.1    Miao, C.H.2    Patijn, G.A.3    Spratt, S.K.4    Danos, O.5    Nagy, D.6    Gown, A.M.7
  • 35
    • 0030902985 scopus 로고    scopus 로고
    • Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus
    • Herzog RW, Hagstrom JN, Kung SH, Tai SJ, Wilson JM, Fisher KJ, High KA. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci USA 1997; 94: 5804-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5804-5809
    • Herzog, R.W.1    Hagstrom, J.N.2    Kung, S.H.3    Tai, S.J.4    Wilson, J.M.5    Fisher, K.J.6    High, K.A.7
  • 38
  • 41
    • 0029552960 scopus 로고
    • Factor IX: Molecular structure, epitopes, and mutations associated with inhibitor formation
    • High KA. Factor IX: molecular structure, epitopes, and mutations associated with inhibitor formation. Adv Exp Med Biol 1995; 386: 79-86.
    • (1995) Adv Exp Med Biol , vol.386 , pp. 79-86
    • High, K.A.1
  • 42
    • 0026664109 scopus 로고
    • Direct estimate of the haemophilia B (factor DC deficiency) mutation rate and of the ratio of the sex-specific mutation rates in Sweden
    • Montandon AJ, Green PM, Bentley DR, Ljung R, Kling S, Nilsson IM, Giannelli F. Direct estimate of the haemophilia B (factor DC deficiency) mutation rate and of the ratio of the sex-specific mutation rates in Sweden. Hum Genet 1992; 89: 319-22.
    • (1992) Hum Genet , vol.89 , pp. 319-322
    • Montandon, A.J.1    Green, P.M.2    Bentley, D.R.3    Ljung, R.4    Kling, S.5    Nilsson, I.M.6    Giannelli, F.7
  • 44
    • 0025960560 scopus 로고
    • Somatic mosaicism and female to female transmission in a kindred with hemophilia B (factor IX deficiency)
    • Taylor SAM, Deugau KV, Lillicrap DP. Somatic mosaicism and female to female transmission in a kindred with hemophilia B (factor IX deficiency). Proc Natl Acad Sci USA 1991; 88: 39-42.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 39-42
    • Taylor, S.A.M.1    Deugau, K.V.2    Lillicrap, D.P.3
  • 45
    • 0020050283 scopus 로고
    • Hemophilia B Leyden: A sex linked hereditary disorder that improves after puberty
    • Briet E, Bertina RM, Van Tilburg NH, Veltkamp JJ. Hemophilia B Leyden: A sex linked hereditary disorder that improves after puberty. N Engl J Med 1982; 306: 788-92.
    • (1982) N Engl J Med , vol.306 , pp. 788-792
    • Briet, E.1    Bertina, R.M.2    Van Tilburg, N.H.3    Veltkamp, J.J.4
  • 46
    • 0027318851 scopus 로고
    • Age-dependent effect on the level of factor IX
    • Sweeney JD, Hoernig LA. Age-dependent effect on the level of factor IX. Am J Clin Pathol 1993; 99: 687-8.
    • (1993) Am J Clin Pathol , vol.99 , pp. 687-688
    • Sweeney, J.D.1    Hoernig, L.A.2
  • 48
    • 0007686099 scopus 로고
    • The inheritance of Christmas factor
    • Simpson NE, Biggs R. The inheritance of Christmas factor. Br J Haematol. 1962; 8: 191-203.
    • (1962) Br J Haematol. , vol.8 , pp. 191-203
    • Simpson, N.E.1    Biggs, R.2
  • 49
    • 0025286228 scopus 로고
    • Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B
    • Crossley M, Brownlee GG. Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Nature 1990; 345: 444-6.
    • (1990) Nature , vol.345 , pp. 444-446
    • Crossley, M.1    Brownlee, G.G.2
  • 50
    • 0026747855 scopus 로고
    • Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden
    • Reijnen MJ, Sladek FM, Bertina RM, Reitsma PH. Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden. Proc Natl Acad Sci USA 1992; 89: 6300-3.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6300-6303
    • Reijnen, M.J.1    Sladek, F.M.2    Bertina, R.M.3    Reitsma, P.H.4
  • 51
    • 0030067692 scopus 로고    scopus 로고
    • Transcriptional regulation of the human factor IX promoter by the orphan receptor super-family factor, HNF4, ARP1 and COUP/Ear3
    • Naka H, Brownlee GG. Transcriptional regulation of the human factor IX promoter by the orphan receptor super-family factor, HNF4, ARP1 and COUP/Ear3. Br J Haematol 1996; 92: 231-40.
    • (1996) Br J Haematol , vol.92 , pp. 231-240
    • Naka, H.1    Brownlee, G.G.2
  • 52
    • 0027175969 scopus 로고
    • Nucleotide substitutions at the -6 position in the promoter region of the factor IX gene result in different severity of hemophilia B Leyden: Consequences for genetic counseling
    • Vidaud D, Tartary M, Costa J-M, Bahnak BR, GispertSanchez S, Fressinaud E, Gazengel C, et al. Nucleotide substitutions at the -6 position in the promoter region of the factor IX gene result in different severity of hemophilia B Leyden: Consequences for genetic counseling. Hum Genet 1993; 91: 241-4.
    • (1993) Hum Genet , vol.91 , pp. 241-244
    • Vidaud, D.1    Tartary, M.2    Costa, J.-M.3    Bahnak, B.R.4    Gispert-Sanchez, S.5    Fressinaud, E.6    Gazengel, C.7
  • 53
    • 0022254509 scopus 로고
    • The prophylactic treatment of hemophilia B Leyden with anabolic steroids
    • Briet E, Wijnands MC, Veltkamp JJ. The prophylactic treatment of hemophilia B Leyden with anabolic steroids. Ann Int Med 1985; 103:225-6.
    • (1985) Ann Int Med , vol.103 , pp. 225-226
    • Briet, E.1    Wijnands, M.C.2    Veltkamp, J.J.3
  • 54
    • 0026767136 scopus 로고
    • Recovery from hemophilia B Leyden: An androgen-responsive element in the factor IX promoter
    • Crossley M, Ludwig M, Stowell KM, De Vos P, Olek K, Brownlee GG. Recovery from hemophilia B Leyden: An androgen-responsive element in the factor IX promoter. Science 1992; 257: 377-9.
    • (1992) Science , vol.257 , pp. 377-379
    • Crossley, M.1    Ludwig, M.2    Stowell, K.M.3    De Vos, P.4    Olek, K.5    Brownlee, G.G.6
  • 56
    • 0027479495 scopus 로고
    • Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation
    • Picketts DJ, Lillicrap DP, Mueller CR. Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation. Nature Genet 1993; 3: 175-9.
    • (1993) Nature Genet , vol.3 , pp. 175-179
    • Picketts, D.J.1    Lillicrap, D.P.2    Mueller, C.R.3
  • 57
    • 0028801352 scopus 로고
    • X-ray structure of clotting factor IXa: Active site and module structure related to Xase activity and hemophilia B
    • Brandstetter H, Bauer M, Huber R, Lollar P, Bode W. X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Proc Natl Acad Sci USA 1995; 92: 9796-800.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9796-9800
    • Brandstetter, H.1    Bauer, M.2    Huber, R.3    Lollar, P.4    Bode, W.5
  • 58
    • 0029839951 scopus 로고    scopus 로고
    • A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism
    • Chu K, Wu SM, Stanley T, Stafford DW, High KA. A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism. J Clin Invest 1996; 98: 1619-25.
    • (1996) J Clin Invest , vol.98 , pp. 1619-1625
    • Chu, K.1    Wu, S.M.2    Stanley, T.3    Stafford, D.W.4    High, K.A.5
  • 59
    • 8544283812 scopus 로고    scopus 로고
    • Missense mutations at ALA-10 in the factor IX propeptide: An insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy
    • Oldenburg J, Quenzel EM, Harbrecht U, Fregin A, Kress W, Muller CR, Hertfelder HJ, et al. Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy. Br J Haematol 1997; 98: 240-4.
    • (1997) Br J Haematol , vol.98 , pp. 240-244
    • Oldenburg, J.1    Quenzel, E.M.2    Harbrecht, U.3    Fregin, A.4    Kress, W.5    Muller, C.R.6    Hertfelder, H.J.7
  • 60
    • 0027528498 scopus 로고
    • Factor VIII inhibitors: A continuing problem
    • Hoyer LW. Factor VIII inhibitors: A continuing problem. J Lab Clin Med 1993; 121: 385-7.
    • (1993) J Lab Clin Med , vol.121 , pp. 385-387
    • Hoyer, L.W.1
  • 61
    • 0015993844 scopus 로고
    • Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom
    • Biggs R. Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol 1974; 26: 313-29.
    • (1974) Br J Haematol , vol.26 , pp. 313-329
    • Biggs, R.1
  • 62
    • 0026622961 scopus 로고
    • Prevalence of inhibitors in a population of 3435 hemophilia patients in France. French Hemophilia Study Group
    • Sultan Y. Prevalence of inhibitors in a population of 3435 hemophilia patients in France. French Hemophilia Study Group. Thromb Haemost 1992; 67: 600-2.
    • (1992) Thromb Haemost , vol.67 , pp. 600-602
    • Sultan, Y.1
  • 63
    • 0002668790 scopus 로고
    • Factor IX inhibitors in haemophilia B patients: Their incidence and prospects for development with high purity factor IX products
    • Briet E. Factor IX inhibitors in haemophilia B patients: their incidence and prospects for development with high purity factor IX products. Blood Coag Fibrin 1991; 2: 47-50.
    • (1991) Blood Coag Fibrin , vol.2 , pp. 47-50
    • Briet, E.1
  • 66
    • 0027473752 scopus 로고
    • Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group
    • Lusher JM, Arkin S, Abildgaard CF, Schwartz RS. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med 1993; 328: 453-59.
    • (1993) N Engl J Med , vol.328 , pp. 453-459
    • Lusher, J.M.1    Arkin, S.2    Abildgaard, C.F.3    Schwartz, R.S.4
  • 69
    • 0023099698 scopus 로고
    • Heterogeneity of the factor IX locus in nine hemophilia B inhibitor patients
    • Matthews RJ, Anson DS, Peake IR, Bloom AL. Heterogeneity of the factor IX locus in nine hemophilia B inhibitor patients. J Clin Invest 1987; 79: 746-53.
    • (1987) J Clin Invest , vol.79 , pp. 746-753
    • Matthews, R.J.1    Anson, D.S.2    Peake, I.R.3    Bloom, A.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.