Asymmetry of the mean-variability tradeoff raises questions about the model in investigations of individual bioequivalence

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 8, 1998, Pages 450-457

  Endrenyi, L ^a   Hao, Y ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b QLT PhotoTherapeutics Inc   (Canada)

Author keywords

Benefits; Individual bioequivalence; Intraindividual variance; Penalties; Regulatory criteria; Simulated trials; Tradeoff relationship

Indexed keywords

ARTICLE; BIOEQUIVALENCE; DRUG FORMULATION; FOOD AND DRUG ADMINISTRATION; PROBABILITY; SIMULATION; VARIANCE;

CLINICAL TRIALS; HUMANS; MODELS, STATISTICAL; PHARMACOKINETICS; THERAPEUTIC EQUIVALENCY;

EID: 0031857671     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

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