On pineal calcification and its relation to subjective sleep perception: A hypothesis-driven pilot study

Psychiatry Research - Neuroimaging

Volumn 82, Issue 3, 1998, Pages 187-191

  Kunz, Dieter ^a   Bes, Frederik ^a   Schlattmann, Peter ^a   Herrmann, Werner Martin ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Calcification; Circadian rhythm disorder; Melatonin; Pineal gland; Sleep

Indexed keywords

MELATONIN;

ADULT; AGED; ARTICLE; CALCIFICATION; CIRCADIAN RHYTHM; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; HUMAN; HYPOTHESIS; MALE; PILOT STUDY; PINEAL BODY DISEASE; PRIORITY JOURNAL; SLEEP DISORDER;

ADULT; AGED; AGED, 80 AND OVER; CALCINOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PINEAL GLAND; SLEEP; SLEEP DISORDERS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0031856961     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(98)00013-4     Document Type: Article

References (19)

1. Alcolada, J.C., Moore, I.E., Weller, R.O., 1986. Calcification in the human choroid plexus meningiomas and pineal gland. Neuropathology and Applied Neurobiology 12, 235-250.
2. Arendt, J., 1995. Melatonin and the Mammalian Pineal Gland. Chapman and Hall, London.
3. Bojkowski, C.J., Arendt, J., 1990. Factors influencing urinary 6-sulphatoxymelatonin, a major melatonin metabolite, in normal human subjects. Clinical Endocrinology 33, 435-444.
4. Collett, D., 1991. Analysis of Binary Data. Chapman and Hall, London.
5. Commentz, J.C., Fischer, P., Stegner, H., Winkler, P., Helmke, K., Willig, R.P., 1986. Pineal calcification does not affect melatonin production. Journal of Neural Transmission 21, 481.
6. Garfinkel, D., Laudon, M., Nof, D., Zisapel, N., 1995. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 346, 541-544.
7. Haimov, I., Lavie, P., Laudon, M., Herer, P., Vigder, C., Zisapel, N., 1995. Melatonin replacement therapy of elderly insomniacs. Sleep 18, 598-603.
8. Humbert, W., Pèvet, P., 1995a. Calcium concretions in the pineal gland of aged rats: an ultrastructural and microanalytical study of their biogenesis. Cell Tissue Research 279, 565-573.
9. Humbert, W., Pèvet, P., 1995b. The pineal gland of the aging rat: calcium localization and variation in the number of pinealozytes. Journal of Pineal Research 18, 32-40.
10. Krstic, R., 1986. Pineal calcification: its mechanism and significance. Journal of Neural Transmission 21, 415-432.
11. MacFarlane, J.G., Cleghorn, J.M., Brown, G.M., Streiner, D.L., 1991. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biological Psychiatry 30, 371-376.
12. McCullagh, P., Nelder, J.A., 1989. Generalized Linear Models. Chapman and Hall, London, pp. 21-34, 114-122.
13. Reiter, R.J., 1995. The pineal gland and melatonin in relation to aging: a summary of the theories and of the data. Experimental Gerontology 30, 199-212.
14. Roth, T., Roehrs, T.A., Carskadon, M.A., Dement, W.C., 1994. Daytime sleepiness and alertness. In: Kryger, M.H., Roth, T., Dement, W.C. (Eds.), Principles and Practice of Sleep Medicine. W.B. Saunders Company, Philadelphia, pp. 40-49.
15. Sandyk, R., Kay, S.R., 1991. Pineal calcification in schizophrenia. Relationship to age of onset and tardive dyskinesia. Schizophrenia Research 5, 85-86.
16. Schörner, W., Kunz, D., Henkes, H., Sander, B., Schmidt, D., Felix, R., 1991. Detection of calcifications by MRI. ROFO Fortschritte der Röntgenstrahlen 154, 430-437.
17. Schmid, H.A., 1993. Decreased melatonin biosynthesis, calcium flux, pineal gland calcification and aging: a hypothetical framework. Gerontology 39, 189-199.
18. Skene, D.J., Vivien-Roels, B., Sparks, D.L., Hunsacker, P., Pèvet, P., Ravid, D., Swaab, D.F., 1990. Daily variations in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease. Brain Research 528, 170-174.
19. Vitiello, M.V., 1996. Sleep disorders and aging. Current Opinions in Psychiatry 9, 84-289.