Synthetic analogs of vitamin D3 have inhibitory effects on breast cancer cell lines

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1703-1708

  Fioravanti, L ^a   Miodini, P ^a   Cappelletti, V ^a   Di Fronzo, G ^a,b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CNR   (Italy)

Author keywords

Breast cancer; Synthetic analogs; Vitamin D3

Indexed keywords

CALCITRIOL; COLECALCIFEROL DERIVATIVE; ESTRADIOL; PROGESTERONE RECEPTOR; RO 24 5531; RO 25 6760; SOMATOMEDIN C; STEROID RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE; CELL STRAIN MCF 7; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; RADIOASSAY;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CALCITRIOL; CELL CYCLE; CELL DIVISION; CELL LINE; CHOLECALCIFEROL; FEMALE; GROWTH SUBSTANCES; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, IGF TYPE 1; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0031856816     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. De Luca HF: The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J 2: 224-236, 1988.
2. Walters MR: Newly identified actions of vitamin D endocrine system. Endocrine Rev 13: 765-784, 1992.
3. 3 metabolites. Cancer Res 43: 4443-4447, 1983.
4. 3 on human cancer cells in vivo. J Steroid Biochem 27: 825-828, 1987.
5. Chouvet C, Berger U, Coombes RC: 1,25-dihydroxyvitamin D3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20). J Steroid Biochem 24: 373-376, 1986.
6. Berger U, Wilson P, McClelland RA, Colston K, Haussler MR, Pike JW and Coombes RC: Immunocytochemical detection of 1a,25-dihydroxyvitamin D3 receptor in breast cancer. Cancer Res 47: 6793-6799, 1987.
7. Cappelletti V, Ruedl C, Miodini P, Fioravanti L, Coradini D, Di Fronzo G and Silvestrini R: Paracrine interaction in co-culture of hormone-dependent and independent breast cancer cells. Breast Cancer Res Treat 26: 275-281, 1993.
8. Soto AM, Sonnenschein C: The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J Steroid Biochem 23: 87-94, 1985.
9. Burton KH: A study of the conditions and the mechanism of diphenylamine reaction for colorimetric determination of deoxyribonucleic acid. Biochem J 62: 315-323, 1956.
10. Cappelletti V, Brivio M, Miodini P, Granata G, Coradini D, Di Fronzo G: Simultaneous estimation of epidermal growth factor receptors and steroid receptors in a series of 136 resectable primary breast tumors. Tumor Biol 9: 200-211, 1988.
11. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-259, 1976.
12. Drewinko B, Loo TL, Brown B et al: Combination chemotherapy in vitro with adriamycin. Observation of additive, antagonistic, and synergistic effects when used in two-drug combinations on cultured human lymphoma cells. Cancer Biochem Biophys 1: 187-195, 1976.
13. Vink-van Wijngaarden T, Pols HAP, Buurman CJ, Birkenhager JC and van Leeuwen JPTM: Combined effects of 1a,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells. Breast Cancer Res Treat 29: 161-168, 1993.
14. Takeo T, lino Y, Aoyagi H, Horii Y, Ikeda F: Influence of 1α,25-dihydroxyvitamin D3 on growth regulation through epidermal growth factor receptor in human breast cancer cell lines. Int J Oncology 10: 287-2-91, 1997.
15. Elstner E, Linker-Israeli M, Said J, Umiel T, de Vos S, Shintaku IP, Heber D, Binderup L, Uskokovic M, and Koeffler HP: 20-epi-vitamin D3 analogues: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Res 55: 2822-2830, 1995.
16. Brenner R, Shabahang M, Shumaker LM, Nauta RJ, Uskokovic M, Evans SRT and Buras RR: The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Letters 92: 77-82, 1995.
17. 3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanism. Cancer Res 54: 1458-64, 1994.
18. L'Allemain G: Decifering the MAP kinase pathway. Progr Growth Factor Res 5: 291-334, 1994.
19. Bunone G, Briand PA, Miksicek RJ, Picard D: Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. Embo J 15: 2174-2183, 1996.