Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits

European Journal of Pharmacology

Volumn 353, Issue 1, 1998, Pages 75-78

  Szilvassy, Zoltan ^a   Sari, Reka ^b   Nemeth, Jozsef ^a   Nagy, Istvan ^b   Csati, Sandor ^b   Lonovics, Janos ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Farnesol; Hypercholesterolaemia; Nitrergic relaxation; Sphincter of Oddi

Indexed keywords

ATROPINE; CYCLIC GMP; CYCLIC NUCLEOTIDE; FARNESOL; GUANETHIDINE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERCHOLESTEROLEMIA; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; NONHUMAN; ODDI SPHINCTER; PRIORITY JOURNAL; RABBIT;

ANIMALS; CYCLIC GMP; FARNESOL; HYPERCHOLESTEROLEMIA; ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; RABBITS; SPHINCTER OF ODDI;

EID: 0031856541     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00449-X     Document Type: Article

References (15)

1. Allesher, H.D., Kurjak, M., Huber, A., Trudrung, P., Schusdziarra, V., 1996. Regulation of VIP release from rat enteric nerve terminals: evidence for a stimulatory effect of NO. Am. J. Physiol. 271, G568-G574.
2. Ferdinandy, P., Szilvassy, Z., Horvath, L.I., Csont, T., Csonka, C., Nagy, E., Szentgyorgyi, R., Nagy, I., Koltai, M., Dux, L., 1997. Loss of pacing-induced preconditioning in rat hearts: role of nitric oxide and cholesterol-enriched diet. J. Mol. Cell. Cardiol. 29, 3321-3333.
3. Ferdinandy, P., Csont, T., Szilvassy, Z., Tosaki, A., Dux, L., 1998. Inhibition of HMG-CoA reductase, similarly to hypercholesterolaemia, inhibits preconditioning in rat hearts. J. Mol. Cell. Cardiol. 30, A77.
4. Flavahan, N.A., 1992. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation 85, 1927-1938.
5. Goldstein, J.L., Brown, M.S., 1990. Regulation of mevalonate pathway. Nature 343, 425-430.
6. Lonovics, J., Jakab, I., Szilvassy, J., Szilvassy, Z., 1994. Regional differences in nitric oxide-mediated relaxation of the rabbit sphincter of Oddi. Eur. J. Pharmacol. 255, 117-122.
7. Moncada, S., Palmer, M.J., Higgs, E.A., 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
8. Pauletzki, J.G., Sharkey, K.A., Davison, J.S., Bomzon, A., Shaffer, E.A., 1993. Involvement of L-arginine-nitric oxide pathways in the neural relaxation of the sphincter of Oddi. Eur. J. Pharmacol. 232, 263-270.
9. Roullet, J.-B., Xue, H., Pappu, A.S., Roullet, C.M., Holcomb, S., McCarron, D.A., 1993. Mevalonate availability and cardiovascular functions. Proc. Natl. Acad. Sci. USA 90, 11728-11732.
10. Roullet, J.-B., Xue, H., Roullet, C.M., Fletcher, W.S., Cipolla, M.J., Harker, C.T., McCarron, D.A., 1995. Mevalonate availability controls human and rat resistance vessel function. J. Clin. Invest. 96, 239-244.
11. Szilvassy, Z., Ferdinandy, P., Bor, P., Jakab, I., Lonovics, J., Koltai, M., 1994. Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning. Am. J. Physiol. 266, H2033-H2041.
12. Szilvassy, Z., Ferdinandy, P., Szilvassy, J., Nagy, I., Karcsu, S., Lonovics, J., Dux, L., Koltai, M., 1995. The loss of pacing-induced preconditioning in atherosclerotic rabbits: role of hypercholesterolaemia. J. Mol. Cell. Cardiol. 27, 2559-2569.
13. Szilvassy, Z., Nagy, I., Szilvassy, J., Jakab, I., Csati, S., Lonovics, J., 1996. Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits. Eur. J. Pharmacol. 301, R17-R18.
14. Szilvassy, Z., Lonovics, J., Jakab, I., Nagy, I., 1997a. Glibenclamide sensitivity of neural relaxation of the rabbit sphincter of Oddi. Pharmacol. Res. 36, 129-133.
15. Szilvassy, Z., Nagy, I., Madacsy, L., Hajnal, F., Takacs, T., Velosy, B., Lonovics, J., 1997b. Beneficial effect of lovastatin on sphincter of Oddi dysfunction in hypercholesterolaemia and hypertriglyceridaemia. Am. J. Gastroenterol. 92, 900-902.