Glucose-induced increase in paracellular permeability and disruption of β-receptor signaling in retinal endothelium

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 9, 1998, Pages 1676-1684

  Haselton, Frederick R ^a,c   Dworska, Elizabeth J ^a   Huffman, Loren H ^b  

^a School of Engineering 299 Jacobs Hall   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CATTLE; GLUCOSE METABOLISM; NONHUMAN; PRIORITY JOURNAL; RETINA BLOOD FLOW; RETINA CAPILLARY; RETINA CELL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ADRENERGIC BETA-AGONISTS; ANIMALS; CAPILLARY PERMEABILITY; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FLUORESCEIN; GLUCOSE; ISOPROTERENOL; MICROSCOPY, ELECTRON, SCANNING; RECEPTORS, ADRENERGIC, BETA; RETINAL VESSELS; VITAMIN B 12;

EID: 0031855655     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Porte D, Schwanz MW. Diabetes complications: why is glucose potentially toxic? Science. 1996;272:699-700.
2. Frank RN. On the pathogenesis of diabetic retinopathy: a 1990 update. Ophthalmology. 1991;98:586-593.
3. King GL, Shiba T, Oliver J, et al. Cellular molecular abnormalities in the vascular endothelium of diabetes mellitus. Ann Rev Med. 1994;45:179-188.
4. Hempel A, Maasch C, Heintze U, et al. High glucose concentrations increase endothelial cell permeability via activation of protein kinase Ça. Cire Res. 1997;81:363-371.
5. Esposito C, Gerlach H, Brett J, et al. Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties. J Exp Med. 1989;170:1387-1407.
6. Gillies MC, Su T, Stayt J, Simpson JM, Naidoo D, Saalonikas C. Effect of high glucose on permeability of retinal capUlary endothelium in vitro. Invest Ophtbalmol Vis Sci. 1997;38:635-642.
7. Haselton FR, Dworska E, Evans SS, Hoffman LH, Alexander JS. Modulation of retinal endothelial barrier in an in vitro model of the retinal microvasculature. Exp Eye Res. 1996;63:211-222.
8. Gitlin JD, D'Amore PA. Culture of retinal capillary cells using selective growth media. Mietweise Res. 1983;26:74-80.
9. Carson MP, Haudenschild CC. Microvascular endothelium and pericytes: High yield, low passage cultures. In Vitro. 1986;22:345354.
10. Haselton FR, Mueller SN, Howell RE, Levine EM, Fishman AP. Chromatographie demonstration of reversible changes in endothelial permeability. J Appl Physiol. 1989:67:2032-2048.
11. Crone C. Permeability of capillaries in various organs as determined by use of the indicator diffusion method. Acta Physiol Scanel. 1963;48:292-305.
12. Sangren WC, Sheppard CW. Mathematical derivation of the exchange of a labeled substance between a liquid flowing in a vessel and an external compartment. Bull Math Biophys. 1953:15:387-394.
13. Laties AM, Rapoport S. The blood-ocular barriers under osmotic stress. Arch Ophthalmol. 1976;94:1086-1091.
14. Laties AM, Rapoport SI, McGlinn A. Hypertensive breakdown of cerebral but not of retinal blood vessels in rhesus monkey. Arch Ophthalmol. 1976;97:1511-1514.
15. King GL, Burman AB, Bonner-Weir S, Carson MP. Regulation of vascular permeability in cell culture. Diabetes. 1987;36:1460-1467.
16. Yamashita T, Minura K, Umeda F, et al. Increased transendothelial permeation of albumin by high glucose concentration. Metabolism. 1995:44:739-744.
17. Lynch JJ, Ferro TJ, Blumenstock FA, et al. Increased albumin permeability mediated by protein kinase C activation. J Clin Invest. 1990;85:1991-1998.
18. Siflinger-Birnboim A, Del Vechio PJ, Cooper JA, Blumenstock FA, Shepard JM, Malik AB. Molecular sieving characteristics of the cultured endothelial monolayer. J Cell Physiol. 1987;132: 111-117.
19. Silbiger SR, Cohen AJ, Fishman JB, Stoff JS. Defective glomerular β-adrenergic signal transmission in spontaneously diabetic rats. J Lab Clin Meet. 1994:249-254.
20. Katovich MJ, Marks KS, Sninsky CA. Fffect of insulin on the altered thyroid function and adrenergic responsiveness in the diabetic rat. Can J Physiol Pbarmacol. 1993;71:568-575.
21. Trovik TS, Jaeger R, Jorde R, Sager G. Reduced sensitivity to β-adrenoreceptor stimulation and blockade in insulin dependent patients with diabetes with hypoglycaemia unawareness. Br J Clin Pbarmacol. 1994;38:427-432.
22. Alexander JS, Patton WF, Christman B, Larsen L, Haselton FR. Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro. Am J Physiol. 1998;274:H115rH122.
23. Gould GW, Holman GD. The glucose transporter family: structure, function and tissue specific expression. BiocbemJ. 1993:295:329341.
24. Kaiser N, Sasson S, Feener EP, et al. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes. 1993;42:80-89.
25. Kumagai AK, Glascow BJ, Pardridge WM. GLUT1 Glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci. 1994;35:2887-2894.
26. Harris TR, Roselli RJ. Exchange of small molecules in the normal and abnormal lung circulatory bed. In: Chang HK, Paiva M, eds. Respiratory Physiology: An Analytical Approach. Vol 40. Lung Biology and Health Disease Series. New York: Dekker; 1989.
27. Orlidge A, D'Amore PA. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J Cell Biol. 1987; 105:1455-1462.
28. Haselton FR, Woodall JH, Alexander JS. Neutrophil-endothelial interactions in a cell column model of the microvasculature: effects of fMLP. Microcirculation. 1996;3:329-342.