Phase II study of mitoguazone, cyclophosphamide, doxorubicin, vincristine and prednisone for patients with diffuse histologic subtypes of non-Hodgkin's lymphoma: An Eastern Cooperative Oncology Group study (PE481)

Leukemia and Lymphoma

Volumn 30, Issue 5-6, 1998, Pages 601-607

  Wiernik, Peter H ^a   Moore, Dirk F ^b   Bennett, John M ^c   Vogl, Steven E ^a   Harris, Jules E ^d   Luger, Selina ^e   Oken, Martin M ^f   Glick, John H ^e  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f Virginia Piper Cancer Institute   (United States)

Author keywords

CHOP; COPA; Lymphoma; Mitoguazone

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; MITOGUAZONE; PREDNISONE; VINCRISTINE;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CARDIOTOXICITY; CLINICAL TRIAL; DIARRHEA; DRUG HYPERSENSITIVITY; FEMALE; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MALE; NONHODGKIN LYMPHOMA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0031855051     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057572     Document Type: Article

References (15)

1. Pleshkewych, A., Kramer, D. L., Kelly, E. et al. (1980). Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal bis (guanylhydrazone). Cancer Res, 40, 4533-4540.
2. Sartorelli, A. C., Ianotti, A. T., Booth, B. A., Schneider, F. H., Bertino, J. R. and Johns, D. G. (1965). Complex formation with DNA and inhibition of nucleic acid synthesis by methylglyoxal bis (guanylhydrazone). Biochim Biophys Acta, 103, 174-176.
3. Knight, W. A. III, Fabian, C., Costanzi, J. T. et al. (1983). Mrthylglyoxal bis-guanylhydrazone (methyl GAG, MGBG). in lymphoma and Hodgkin's disease. Invest New Drugs, 1, 225-237.
4. Warrell, R. P. Jr., Lee, B. J., Kempin, S. T., Lacher, M. J., Straus, D. J. and Young, C. W. (1981). Effectiveness of methyl-GAG (methylglyoxal-bis guanylhydrazone) in patients with advanced malignant lymphoma. Blood, 57, 1011-1014.
5. Levine, A. M., Tulpule, A., Tessman, D., Kaplan, L., Giles, F., Luskey, B. D., Scadden, D. T., Northfelt, D. W., Silverberg, I., Wernz, J., Espina, B. and Von Hoff, D. (1997). Mitoguazone therapy in patients with refractory relapsed AIDS-related lymphoma: Results from a multicenter phase II trial. J Clin Oncol, 15, 1094-1103.
6. Cox, D. R. and Oakes, D. (1984). The Analysis of Survival Data, (Chapman and Hall. London).
7. Gottlieb, A. J., Anderson, J. R., Ginsberg, S. J. et al. (1990). A randomized comparison of methotrexate dose and the addition of bleomycin to CHOP therapy for diffuse large cell lymphoma and other non-Hodgkin's lymphoma. Cancer and Leukemia Group B study 7851. Cancer, 66, 1888-1896.
8. O'Connell, M. J., Harrington, D. P., Earle, J. D., Johnson, G. J., Glick, J. H., Carbone, P. P., Creech, R. H., Neiman, R. S., Mann, R. B. and Silverstein, M. N. (1987). Prospectively randomized clinical trial of three intensive chemotherapy regimens for the treatment of advnaced unfavorable histology non-Hodgkin's lymphoma. J Clin Oncol, 5, 1329-1339.
9. Fisher, R. I., Gaynor, E. R., Dahlberg, S., Oken, M. M., Grogan, T. M., Mize, E. M., Glick, J. H., Coltman, C. A. Jr. and Miller, T. P. (1993). Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med, 328, 1002-1006.
10. Montserrat, E., García-Conde, J., Viñolas, N., López-Guillermo, A., Hernández-Nieto, L., Zubizarreta, A., Maldonado, J., Alcalá, A., Faura, M. V., Llorente, A., Bladé, J., Fontanillas, M. and Estapé, J. (1996). CHOP vs. ProMACE-CytaBOM in the treatment of aggressive non-Hodgkin's lymphomas: long-term results of a multicenter randomized trial. Eur J Haematol, 57, 377-383.
11. Linch, D. C., Hudson, B. V., Hancock, B. W., Hoskin, P. J., Cunningham, D. C., Newland, A. C., Milligan, D. W., Stevenson, P. A., Wood, J. K., MacLennan, K. A., Anderson, L., Gregory, W. M. and Vaughn Hudson, G. (1996). A randomised comparison of a third-generation regimen (PACEBOM) with a standard regimen (CHOP) in patients with histologically aggressive non-Hodgkin's lymphoma: a British national Lymphoma Investigation report. Br J Cancer, 74, 318-322.
12. Cooper, I. A., Wolf, M. M., Robertson, T. I., Fox, R. M., Matthews, J. P., Stone, J. M., Ding, J. C., Dart, G., Matthews, J., Firkin, F. C., Lowenthal, R. M. and Ironside, P. (1994). Randomized comparison of MACOP-B with CHOP in patients with intermediate-grade non-Hodgkin's lymphoma. J Clin Oncol, 12, 769-778.
13. Zinzani, P. L., Martelli, M., Storti, S., Musso, M., Canonetti, M., Leone, G., Cajozzo, A., Papa, G., Iannitto, E., Perrotti, A., Bendandi, M., Gherlinzoni, F., Gentilini, P., Rossi, G., Attini, E., Mandelli, F. and Tura, S. (1995). Phase III comparative trial using CHOP vs CIOP in the treatment of advanced intermediate-grade non-Hodgkin's lymphoma. Leukemia & Lymphoma, 19, 329-335.
14. Gordon, L. I., Harrington, D., Andersen, J., Colgan, J., Glick, J., Neiman, R., Mann, R., Resnick, G. D., Barcos, M., Gottlieb, A. and O'Connell, M. (1992). Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma. N Engl J Med, 327, 1342-1349.
15. Verdonck, L. F., van Putten, W. L. J., Hagenbeek, A., Schouten, H. C., Sonneveld, P., van Imhoff, G. W., Kluin-Nelemans, H. C., Raemaekers, J. M. M., van Oers, R. H. J., Haak, H. L., Schots, R., Dekker, A. W., de Gast, G. C. and Löwenberg, B. (1995). Comparison of CHOP chemotherapy with autologous bone marrow transplantation for slowly responding patients with aggressive non-Hodgkin's lymphoma. N Engl J Med, 332, 1045-1051