Initiating and promoting effects of concurrent oral administration of ethylenethiourea and sodium nitrite on uterine endometrial adenocarcinoma development in donryu rats

In Vivo

Volumn 12, Issue 4, 1998, Pages 363-368

  Nishiyama, Kan ^a,b   Ando Lu, Jin ^a   Nishimura, Susumu ^a   Takahashi, Masakazu ^a   Yoshida, Midori ^a   Sasahara, Kenji ^a   Miyajima, Katsuhiro ^a   Maekawa, Akihiko ^a  

^a SASAKI INSTITUTE   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Donryu rats; Endometrial adenocarcinomas; Ethylenethiourea; N nitroso ethylenethiourea; Sodium nitrite

Indexed keywords

2 IMIDAZOLIDINETHIONE; ETHYLNITROSOUREA; MACROGOL; SODIUM NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; ESTRUS; FEMALE; FORESTOMACH; HYPERPLASIA; NEOPLASM; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STOMACH LESION; UTERUS CAVITY;

EID: 0031854997     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Brinton LA and Hoover RN: Epidemiology of gynecologic cancers. In: Principles and Practice of Gynecologic Oncology (Hoskins WJ, Rerez CA and Young RC eds). Philadelphia, JB Lippicott Co., 1992, pp 3-26.
2. Masubuchi K, Nemoto H, Masubuchi S, Fujimoto I and Uchino S: Increasing incidence of endometrial carcinoma in Japan. Gynecol Oncol 3: 335-346, 1976.
3. Fox H: Endometrial carcinogenesis and its relation to estrogens. Pathol Res Pract 179: 13-19, 1984.
4. Lingeman CH: Hormones and hormonomimetic compounds in the etiology of cancer. Recent Results Cancer Res 66: 1-48, 1979.
5. Ziel HK: Estrogen's role in endometrial cancer. Obstet Gynecol 60: 509-515, 1982.
6. Anisimov VN and Nikonov AA: Tumours of the vagina, uterus and oviduct. In: Pathology of Tumours in Laboratory Animals Tumours of the Rat (2nd ed) Vol. 1. (Turusov VS and Mohr Ueds). Lyon, IARC, 1990, pp 445-471.
7. Maekawa A: Genital tumors in female rats - Influence of chemicals and/or hormones and host factors on their occurrence. J Toxicol Sci 19: 119-132, 1994.
8. Nagaoka T, Onodera H, Matsushima Y, Todate A, Shibutani M, Ogasawara H and Maekawa A: Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance. J Cancer Res Clin Oncol 116: 623-628, 1990.
9. Ando-Lu J, Takahashi M, Imai S, Ishihara R, Kitamura T, Iijima T, Takano S, Nishiyama K and Maekawa A: High yield induction of uterine endometrial adenocarcinomas in Donryu rats by a single intra-uterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine via the vagina. Jpn J Cancer Res 85: 789-793, 1994.
10. Graham SL, Davis KJ, Hansen WH and Graham CH: Effects of prolonged ethylenethiourea ingestion on the thyroid of the rat. Fd Cosmet Toxicol 13: 493-499, 1975.
11. Ulland BM, Weisburger JH, Weisburger EK, Rice JM and Cypher R: Brief communication: Thyroid cancer in rats from ethyle is thiourea intake. J Natl Cancer Inst 49: 583-584, 1972.
12. Moriya M, Mitsumori K, Kato K, Miyazawa T and Shirasu Y: Carcinogenicity of N-nitroso-ethylene-thiourea in female mice. Cancer Lett 7: 339-342, 1979.
13. Seiler JP: In vivo mutagenic interaction of nitrite and ethylenethiourea. Experimentia 31: 214-215, 1975.
14. Yoshida A, Harada T and Maita K: Tumor induction by concurrent oral administration of ethylenethiourea and sodium nitrite in mice. Toxicol Pathol 21: 303-310, 1993.
15. Yoshida A, Harada T, Hayashi S, Mori I, Miyajima H and Maita K: Endometrial carcinogenesis induced by concurrent oral administration of ethylenethiourea and sodium nitrite in mice. Carcinogenesis 15: 2311-2318, 1994.
16. Newbold RR, Bullock BC and McLachlan JA: Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. Cancer Res 50: 7677-7681, 1990.
17. Takahashi M, Iijima T, Suzuki K, Ando-Lu J, Yoshida M, Kitamura T, Nishiyama K, Miyajima K and Maekawa A: Rapid and high yield induction of endometrial adenocarcinomas in CD-1 mice by a single intrauterine administration of N-ethyl-N-nitrosourea combined with chronic 17 beta-estradiol treatment. Cancer Lett 104: 7-12, 1996.
18. Maekawa A: Neoplasms of the female reproductive organs. In: Atlas of Tumor Pathology of the Fischer Rat (Stinson SF, Schuller HM and Reznik G eds). Florida, CRC Press, 1990, pp 431-472.
19. Takeuchi M, Maekawa A, Tada K and Odashima S: Leukemias and vaginal tumors induced in female Donryu rats by continuous administration of 1-butyl-3,3-dimethyl-1-nitrosourea in the drinking water. J Natl Cancer Inst 56: 1177-1181, 1976.
20. Bokhman JV: Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15: 10-17, 1983.
21. Deligdisch L and Holinka CF: Endometrial carcinoma: two diseases? Cancer Detect Prev 10: 237-246, 1987.
22. Gottardis M, Verdeal KM, Erturk E and Rose DP: Effect of progesterone administration on rat endometrial disease after exposure to N-nitrosomethylurea. Eur J Cancer Clin Oncol 18: 1395-1396, 1982.
23. Fishman J: Aromatic hydroxylation of estrogens. Annu Rev Physiol 45: 61-72, 1983.
24. Fishman J, Schneider J, Hershcopf RJ and Bradlow HL: Increased estrogen 16α-hydroxylase activity in women with breast and endometrial cancer. J Steroid Biochem, Mol Biol 20: 1077-1081, 1984.
25. Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL and Fishman J: Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. New Engl J Med 315: 1305-1309, 1986.
26. Maekawa A, Onodera H, Tanigawa H, Matsuoka C, Kanno J, Ogiu T and Hayashi Y: Spontaneous neoplastic and nonneoplastic lesions in aging Donryu rats. Jpn J Cancer Res (Gann) 77: 882-890, 1986.