Morphine use and pharmacokinetics in patients with chest pain due to suspected or definite acute myocardial infarction

European Journal of Pain

Volumn 2, Issue 2, 1998, Pages 115-125

  Everts, B ^a   Karlson, B W ^a   Herlitz, J ^a   Hedner, T ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ACUTE HEART INFARCTION; ADULT; AGED; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THORAX PAIN;

EID: 0031853725     PISSN: 10903801     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1090-3801(98)90004-0     Document Type: Article

References (28)

1. Aronson JK, Dengler HJ, Dettli L, Follath F. Standardization of symbols in clinical pharmacology. Eur J Clin Pharmacol 1988; 35: 1-7.
2. Bayer AJ. Presentation and management of myocardial infarction in the elderly. Br J Hosp Med 1988; 40: 300-301, 304-306.
3. Bondestam E, Hovgren K, Gaston Johansson F, Jern S, Herlitz J, Holmberg S. Pain assessment by patients and nurses in the early phase of acute myocardial infarction. J of Advanced Nursing 1987; 12: 677-682.
4. Edlund P. Determination of opiates in biological samples by glass capillary chromatography with electron capture detection. J Chromatogr 1981; 206: 109-116.
5. Everts B, Karlson B, Währborg P, Hedner T, Herlitz J. Localization of pain in suspected acute myocardial infarction in relation to final diagnosis, age and sex, and type of infarction. Heart Lung 1996; 25: 430-437.
6. Gibaldi M, Perrier D. Pharmacokinetics. New York: Dekker, 1982.
7. Gong Q, Hedner J, Björkman R, Hedner T. Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain 1992; 48: 249-255.
8. Gong Q, Hedner T, Hedner J, Björkman R, Nordberg G. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide. Eur J Pharmacol 1991; 193: 47-56.
9. Hasselström J. On the kinetics, metabolism and effects of morphine, codeine and their metabolites. Dissertation. Karolinska Institute, Stockholm 1992: 1-63.
10. Herlitz J, Hjalmarson Å, Holmberg S, Swedberg K, Waagstein F, Waldenström J, Waldenström A. Enzymatically and electrocardio-graphically estimated infarct size in relation to pain in acute myocardial infarction. Cardiology 1984; 71: 239-246.
11. Herlitz J, Richter A, Hjalmarson Å, Holmberg S. Variability of chest pain in suspected acute myocardial infarction according to subjective assessment and requirement of narcotic analgesics. Int J Cardiol 1986; 13: 9-22.
12. Herlitz J. Analgesia in myocardial infarction. Drugs 1989; 37: 939-944.
13. Herlitz J. Chest pain in acute myocardial infarction. Cardiology 1990; 77: 421-423.
14. Hofgren K, Bondestam E, Gaston Johansson F, Jern S, Herlitz J, Holmberg S. Initial pain course and delay to hospital admission in relation to myocardial infarct size. Heart Lung 1988; 17: 274-280.
15. Karlson BW, Herlitz J, Pettersson P, Ekvall HE, Hjalmarson A. Patients admitted to the emergency room with symptoms indicative of acute myocardial infarction. J Int Med 1991; 230: 251-258.
16. Karlson BW, Sjölin M, Herlitz J. Clinical factors associated with pain in acute myocardial infarction. Cardiology 1993; 83: 107-117.
17. Mannheimer C, Carlsson CA, Emanuelsson H, Vedin A, Waagstein F, Wilhelmsson C. The effects of transcutaneous electrical nerve stimulation in patients with severe angina pectoris. Circulation 1985; 71: 308-316.
18. Nielsen FE, Gram-Hansen P, Sörensen HP, Klausen IC. Pain in acute myocardial infarction. Cardiology 1990; 77: 424-432.
19. Nordberg G, Borg L, Hedner T, Mellstrand T. CSF and plasma pharmacokinetics of intramuscular morphine. Eur J Clin Pharmacol 1985; 27: 677-681.
20. Pasternak GW, Bodnar RJ, Clark JA, Inturrisi CE. Morphine-6-glucuronide, a potent mu agonist. Life Sci 1987; 41: 2845-2849.
21. Fetch M. Myocardial infarction. In: Julian D, Cramm A, Fox K, Hall R, Poole-Wilson P, editors. Diseases of the Heart. London: Baillière Tindall, 1989; 1157-1191.
22. Sheiner LB, Beal SL. Pharmacokinetic parametric estimates from several least squares procedures. Superiority of extended least squares. J Pharmacokin Biopharm 1985; 13: 185-201.
23. Shimomura K, Kamata O, Ueki S, Ida S, Oguri K, Yoshimura H, Tsukamoto H. Analgesic effect of morphine glucuronides. Tohoku J Exp Med 1971; 105: 45-52.
24. Smith MT, Watt JA, Cramond T. Morphine-3-glucuronide - a potent antagonist of morphine analgesia. Life Sci 1990; 47: 579-585.
25. Stein C, Comisel K, Haimerl E, Yassouridis A, Lehrberger K, Herz A, Peter K. Analgesic effect of intraarticular morphine after arthroscopic knee surgery. New Engl J Med 1991; 325: 1123-1126.
26. Sullivan AF, McQuay HJ, Bailey D, Dickenson AH. The spinal antinociceptive actions of morphine metabolites morphine-6-glucuronide and normorphine in the rat. Brain Res 1989; 482: 219-224.
27. Säwe J. High-dose morphine and methadone in cancer patients; Clinical considerations of oral treatment. Clin Pharmacokinet 1986; 11: 87-106.
28. Venn RF, Michalkiewicz A. Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection. J Chromatogr 1990; 525: 379-388.